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| 1 | 视神经脊髓炎IgG刺激原代培养大鼠星形胶质细胞免疫反应显示文摘视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形胶质细胞的动态免疫过程。培养原代大鼠星形胶质细胞,加入从NMO患者血清中提取或纯化的IgG,星形胶质细胞出现炎性增殖,同时基因表达出现与之匹配的明显变化。且星形胶质细胞反应因子脂质运载蛋白-2、多种趋化因子、细胞因子、应激反应因子的表达均增加。而在培养的原代星形胶质细胞中加入从正常对照者血清中提取的IgG则无上述变化。此星形胶质细胞的反应还与疾病种类相关。从复发缓解型多发硬化、Sj觟gren's或系统性红斑狼疮患者血清中提取的IgG加入培养的原代星形胶质细胞中也不能导致上述变化。笔者推测是NMO IgG与AQP4结合,导致星形胶质细胞出现炎症反应,并出现基因在转录和翻译水平的相应变化。抑制星形胶质细胞的炎症反应可能有助于减少星形胶质细胞增殖,缓解NMO病灶的发展。 | Howe CL Kaptzan T Magaa SM Ayers-Ringler JR LaFrance-Corey RG Lucchinetti CF | 2014 | 神经损伤与功能重建2014，9，3： | 4 |
| 2 | TGFβ1 induces fibronectin synthesis though a c-Jun N-terminal kinase-dependent,Smad4-dependent parthway显示文摘 | HOCEVAR B A BROWN T L HOWE P H | 1999 | EMBO J1999，18，5： | 1 |
| 3 | Void growth simulations in single crystals显示文摘 | O'Regan T L Quinn D F Howe M A MeHugh P E | 1997 | Computational Mechanies1997，20，： | 1 |
| 4 | Studies of potassium ferrite, K1+xFe11O17 显示文摘 | Howe A T Dudley G J | 1976 | J Solid State Chemistry1976，18，： | 1 |
| 5 | Swirling flow pattern in a non-planar model of an interposition vein cuff anastomosis 显示文摘 | T V How R K Fisher J A Brennan | 2006 | Med Eng Phys2006，，28： | 1 |
| 6 | UK Innovation Systems for New and Renewable Energy Technologies: Drivers, Barriers and Systems Failures显示文摘 | Foxon T J Gross R Chase A Howes J Arnall A Anderson D | 2005 | Energy Policy2005，33，16： | 1 |
| 7 | Design and calibration of a microfabricated floating-element shear-stress sensor显示文摘 | Schmidt M A Howe R T Senturia S D | 1998 | IEEE Transactions on Electron Devices1998，35，6： | 1 |
| 8 | Void growth simulations in single crystals显示文摘 | O'Regan T L Quinn D F Howe M A McHugh P E | 1997 | Computational Mechanics1997，20，： | 1 |
| 9 | Approach to designing rotating drum bioreactors for solid-state fermentation on the basis of dimensionless design factors 显示文摘 | HARDIN M T MITCHELL D A HOWES T | 2013 | Biotechnology and Bioengineering2013，67，3： | 1 |
| 10 | De- sign and calibration of a microfabricated floating-element shear- stress sensor 显示文摘 | SCHMIDT M A HOWE R T SENTURIA S D | 1988 | IEEE Transactions on Electron Devices1988，35，6： | 1 |
| 11 | Biodiversity as a barrier to ecological invasion显示文摘 | KENNEDY T A NAEEM S HOWE K M | 2002 | Nature2002，417，： | 1 |
| 12 | Adeno-viral-mediated expression of a kinase-dead mutant of Akt in-duces apoptosis selectively in tumor cells and suppresses tumorgrowth in mice显示文摘 | Jetzt A Howe J A Horn M T Maxwell E Yin Z Johnson D | 2003 | Cancer Res2003，63，： | 1 |
| 13 | Spacecraft trajectory planning with avoidance contraints using mixed- integer linear programming显示文摘 | Richards A Schouwenaars T How J P | 2002 | J of Guidance Control and Dynamics2002，25，4： | 1 |
| 14 | Spacecraft trajectory planning with avoidance constraints using mixed-integer linear programming显示文摘 | Richards A Schouwenaars T How J P | 2002 | Journal of Guidance Control and Dynamics2002，25，4： | 1 |
| 15 | Spacecraft trajectory planning with collision and plume avoidance using mixed-integer linear programming显示文摘 | Richards A Schouwenaars T How J P | 2002 | AIAA J on Guidance Control and Dynamics2002，25，4： | 1 |
| 16 | One--year outcome of hip frac- ture patients admitted to a Singapore hospital:quality of life post-- treatment Singapore显示文摘 | Lee A Y J Chua B S Y Howe T S | 2007 | Med J2007，48，11： | 1 |
| 17 | Plime avoidance maneuver planning using mixed integer linear programming显示文摘 | Richards A How J Schouwenaars T Feron E | 2002 | Journal of Guidance Control and Dynamics2002，25，4： | 1 |
| 18 | Void growth simulations in single crystals显示文摘 | ('Yregan T L Quinn I) F Howe M A Mchugh P E | 1997 | Com- putational Mechanics1997，20，： | 1 |
| 19 | Progeny analysis of glyphosate-selected transgenic soybeans derived from Agrobacterium-mediated transformation显示文摘 | Clemente T E LaValle B J Howe A R | 2000 | Crop Sci2000，40，： | 1 |
| 20 | Carbon and nitrogen dynamics in a grassland soil with varying pH:effect of pH on the denitrification potential and dynamics of the reduction enzymes显示文摘 | Ellis S Howe M T Goulding W T Mugglestone M A Dendooven L | 1998 | Soil Biology & Biochemistry1998，30，： | 1 |
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