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| 1 | 视神经脊髓炎IgG刺激原代培养大鼠星形胶质细胞免疫反应显示文摘视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形胶质细胞的动态免疫过程。培养原代大鼠星形胶质细胞,加入从NMO患者血清中提取或纯化的IgG,星形胶质细胞出现炎性增殖,同时基因表达出现与之匹配的明显变化。且星形胶质细胞反应因子脂质运载蛋白-2、多种趋化因子、细胞因子、应激反应因子的表达均增加。而在培养的原代星形胶质细胞中加入从正常对照者血清中提取的IgG则无上述变化。此星形胶质细胞的反应还与疾病种类相关。从复发缓解型多发硬化、Sj觟gren's或系统性红斑狼疮患者血清中提取的IgG加入培养的原代星形胶质细胞中也不能导致上述变化。笔者推测是NMO IgG与AQP4结合,导致星形胶质细胞出现炎症反应,并出现基因在转录和翻译水平的相应变化。抑制星形胶质细胞的炎症反应可能有助于减少星形胶质细胞增殖,缓解NMO病灶的发展。 | Howe CL Kaptzan T Magaa SM Ayers-Ringler JR LaFrance-Corey RG Lucchinetti CF | 2014 | 神经损伤与功能重建2014，9，3： | 4 |
| 2 | CRITICAL REVIEW - ADHESION IN SURFACE MICROMECHANICAL STRUCTURES [Review]显示文摘 | Maboudian R Howe R T | | 0，，： | 2 |
| 3 | Subsurface evaluation of ground ceramics 显示文摘 | Zhang B Howes T D | 1995 | Annals of the CIRP1995，44，1： | 2 |
| 4 | Endoglin promotes trans forming growth factorediated smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC显示文摘 | Lee NY Ray B How T | 2008 | J Biol Chem2008，283，32： | 1 |
| 5 | A biomechanical study of the human vertebral artery with implications for fatal arterial injury显示文摘 | How T Scraggs M | 2000 | Forensic Sci Int2000，109，： | 1 |
| 6 | Abrasive Machining in the Future显示文摘 | Tonshoff H K Howes T D | 1993 | Annals of the CIRP1993，42，72： | 1 |
| 7 | Surface micro-machined accelerometers 显示文摘 | Boser B E Howe R T | 1996 | Journal of Solid-State Circuits1996，31，3： | 1 |
| 8 | Laterally driven poly-silicon resonant microstructures 显示文摘 | Tang W C Nguyen Tu-Cuong H Howe R T | 1989 | Sensors and Actuators1989，20，12： | 1 |
| 9 | The effect of low molecular weight surfactants and proteins on surface stickiness of sucrose during powder formation through spray-drying显示文摘 | Adhikari B Howes T Wood BJ | 2009 | Journal of Food Engineering2009，94，： | 1 |
| 10 | TGFβ1 induces fibronectin synthesis though a c-Jun N-terminal kinase-dependent,Smad4-dependent parthway显示文摘 | HOCEVAR B A BROWN T L HOWE P H | 1999 | EMBO J1999，18，5： | 1 |
| 11 | Void growth simulations in single crystals显示文摘 | O'Regan T L Quinn D F Howe M A MeHugh P E | 1997 | Computational Mechanies1997，20，： | 1 |
| 12 | Studies of potassium ferrite, K1+xFe11O17 显示文摘 | Howe A T Dudley G J | 1976 | J Solid State Chemistry1976，18，： | 1 |
| 13 | Effect of addition of proteins on the production of amorphous sucrose powder through spraydrying显示文摘 | Adhikari B Howes T Bhandari BR | 2009 | Journal of Food Engineering2009，94，： | 1 |
| 14 | Swirling flow pattern in a non-planar model of an interposition vein cuff anastomosis 显示文摘 | T V How R K Fisher J A Brennan | 2006 | Med Eng Phys2006，，28： | 1 |
| 15 | Cellulose binding protein from the parasitic nematode Heterodera schachtii interacts with Arabidopsis pectin methylesterase: cooperative cell wall modification during parasitism 显示文摘 | Hewezi T Howe P Maier T R | 2008 | The Plant Cell2008，20，： | 1 |
| 16 | Saft of formalin treatments on warm and coolwater fish eggs显示文摘 | Rach J J Howe G E Schreier T M | 1997 | Aquaculture1997，149，： | 1 |
| 17 | Effects of geometry and flow division on flow structures in models of the distal end-to-side anastomosis 显示文摘 | Hughes P E How T W | 1996 | Journal of Biomechanics1996，29，： | 1 |
| 18 | Strain-engineered InAs/GaAs quantum dots for long wavelength emission显示文摘 | LE RUE C HOWE P JONES T S | 2003 | Phys Rev2003，67，16： | 1 |
| 19 | The type Ⅲ TGF-beta receptor suppresses breast cancer progression显示文摘 | Dong M How T Kirkbride K C | 2007 | J Clin Invest2007，117，1： | 1 |
| 20 | Bone morphegenetic proteins in- duce pancreatic cancer cell invasiveness through a Smadl-dependent mechanism that involves matrix metalloproteinase-2显示文摘 | Gordon KJ Kirkbride KC How T | 2009 | Carcinogenesis2009，30，2： | 1 |
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