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| 1 | 视神经脊髓炎IgG刺激原代培养大鼠星形胶质细胞免疫反应显示文摘视神经脊髓炎(NMO)主要累及星形胶质细胞,导致中枢神经系统炎症、脱髓鞘和组织损伤。脑内病灶常高表达水通道蛋白4(AQP4),AQP4被认为是NMO血清IgG的抗原目标。根据NMO的可逆性及对NMO病灶演变特点的分析,笔者推测NMO IgG可能诱导了星形胶质细胞的动态免疫过程。培养原代大鼠星形胶质细胞,加入从NMO患者血清中提取或纯化的IgG,星形胶质细胞出现炎性增殖,同时基因表达出现与之匹配的明显变化。且星形胶质细胞反应因子脂质运载蛋白-2、多种趋化因子、细胞因子、应激反应因子的表达均增加。而在培养的原代星形胶质细胞中加入从正常对照者血清中提取的IgG则无上述变化。此星形胶质细胞的反应还与疾病种类相关。从复发缓解型多发硬化、Sj觟gren's或系统性红斑狼疮患者血清中提取的IgG加入培养的原代星形胶质细胞中也不能导致上述变化。笔者推测是NMO IgG与AQP4结合,导致星形胶质细胞出现炎症反应,并出现基因在转录和翻译水平的相应变化。抑制星形胶质细胞的炎症反应可能有助于减少星形胶质细胞增殖,缓解NMO病灶的发展。 | Howe CL Kaptzan T Magaa SM Ayers-Ringler JR LaFrance-Corey RG Lucchinetti CF | 2014 | 神经损伤与功能重建2014，9，3： | 4 |
| 2 | 显示文摘 | Howe JR Roth S Ringold JC | 1998 | Science1998，280，： | 1 |
| 3 | Factors predictive of survival in ampullary carcinoma显示文摘 | Howe JR Klimstra DS | 1998 | Ann Surg1998，228，： | 1 |
| 4 | DNA extraction from paraffin-embedded tissues using a salting-out procedure:a reliable method for PCR amplification of archival material 显示文摘 | Howe JR Klimstra DS Cordon-Cardo C | 1997 | Histol Histopathol1997，12，3： | 1 |
| 5 | Factors predictive of survival in ampullary carcinoma显示文摘 | Klimstra DS Moccia RD | 1998 | Ann Surg1998，228，： | 1 |
| 6 | Magnetic reso- nance neurography of peripheral nerve following experimental crush injury, and correlation with functional deficit 显示文摘 | Cudlip SA Howe FA Griffoths JR | 2002 | J Neurosurg2002，96，4： | 1 |
| 7 | DNA extraction from paraffin-embedded tissues using a salting-out procedure: a reliable method for PCR amplification of archival material显示文摘 | Howe JR Klinstra DS Cordon-Cardo C | 1997 | Histol Histopatho11997，12，3： | 1 |
| 8 | The molecular genetics of pancreatic cancer显示文摘 | Cordon KC | 1997 | Surg Oncol1997，6，1： | 1 |
| 9 | The prevalence of MADH4 and BMPR1A mutations in juven- ile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations 显示文摘 | Howe JR Sayed MG Ahmed AF Ringold J | 2004 | J Med Genet2004，41，7： | 1 |
| 10 | A comparison of radiographic findings in fusion and nonfusion patients ten or more years fol owing lumbar disc surgery显示文摘 | Frymoyer JW Hanley EN Jr Howe J | | 0，，05： | 1 |
| 11 | DNA extraction from paraffin-embedded tissues using a salting-out procedure: a reliable method for PCR amplification of archival material 显示文摘 | Howe JR Klimstra DS Cordon-Cardo C | 1997 | Histol Histopathol1997，12，3： | 1 |
| 12 | hmovative approaches to water allocation: the potential for water markets 显示文摘 | HOWE C W SCHURMEIER D R Jr SHAW W D | 1986 | Water Resources Research1986，26，4： | 1 |
| 13 | DNA extraction from araffin-embedded tissues using a salting-out procedure :a reliable method for PCR amplification of archival material显示文摘 | Howe JR Klimstra DS Cordon-Cardo C | 1997 | Histol Histopathol1997，12，3： | 1 |
| 14 | Hamartomatous polyposis syndromes 显示文摘 | Calva D Howe JR | 2008 | SurgClin North Am2008，88，4： | 1 |
| 15 | Comparison of long-term outcomes after allogeneic hematopoietic stem cell transplantation from matched sibling and unrelated donors 显示文摘 | HOWS JM PASSWEG JR TICHELLI A | 2006 | Bone Marrow Transplantation2006，，38： | 1 |
| 16 | Factors predictive of survival in ampullary carcinoma显示文摘 | Howe JR Klimstra DS Moccia RD | 1998 | Ann Surg1998，228，： | 1 |
| 17 | The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2,BMPR1B,and ACVR1 mutations显示文摘 | Howe JR Sayed MG Ahmed AF | 2004 | Med Genet2004，41，7： | 1 |
| 18 | Plasmodium vivaxTransmission in Africa显示文摘 | Howes RE Reiner RC Jr Battle KE | 2015 | PLoS Negl Trop Dis2015，9，00： | 1 |
| 19 | Mutations in the SMAD4/DPC4 gene in juvenile polyposis显示文摘 | Roth S Ringold JC | 1998 | Science1998，，： | 1 |
| 20 | Common deletion of SMAD4 in juvenile polyposis is a mutational hot spot显示文摘 | Howe JR Shellnut J Wagner B | 2002 | Am J Hum Genet2002，70，5： | 1 |
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