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| 1 | 欧洲呼吸学会和欧洲胸外科医师学会恶性胸膜间皮瘤诊疗指南显示文摘恶性胸膜间皮瘤(malignant pleural mesothelioma,MPM)是一种罕见肿瘤,但发病率正逐渐上升,且预后较差。2008年,欧洲呼吸学会(European Respiratory Society,ERS)和欧洲胸外科医师学会(European Society of Tho-racic Surgeons,ESTS)特别工作组召集各方专家计划制定MPM诊治经验及更新指南。为了使MPM得到及时准确的诊断,专家推荐对患者实施胸腔镜检查,有手术禁忌和胸腔粘连的病例除外。约10%的病例采用标准染色方法无法获得满意的结果。因此我们推荐在胸膜活检的基础上,采用特异性免疫组化标志物。由于目前缺乏一个统一的、切实有效的分期系统,我们推荐应用最新的TNM分期,并且提出三个阶段的治疗前评估。在MPM的治疗中,患者的体力状态评分和组织亚型是目前唯一的、具有重要临床价值的预后因素。在临床试验中,应对其它潜在因素进行初步探讨并予以报道。MPM对化疗高度耐受,仅有少数患者可接受根治性手术。本文对新的治疗方法和策略进行了综述。目前由于最佳综合治疗的资料有限,适合采用多种方案联合治疗策略的患者应被纳入专业机构的前瞻性试验中。 | A. Scherpereel P. Astoul P. Baas T. Berghmans H. Clayson P. de Vuyst H. Dienemann F. Galateau-Salle C. Hennequin G. Hillerdal C. Le Pe'choux L. Mutti J-C. Pairon R. Stahel P. van Houtte J. van Meerbeeck D. Waller W. Weder 宋作庆 徐萧洪 | 2010 | 中国肺癌杂志2010，，10： | 56 |
| 2 | Outcome and prognostic factors in 110 consecutive patients with primary uterine leiomyosarcoma:A Rare Cancer Network study显示文摘Objective: Primary uterine leiomyosarcomas(ULMS) are rare,and the optimal treatment is controversial.We aimed to assess the outcome and prognostic factors in a multicenter population of women treated for primary ULMS.Methods: We retrospectively collected data of 110 women treated in 19 institutions of the Rare Cancer Network(RCN).Inclusion criteria consisted of a pathology report confirming the diagnosis of ULMS,aged 18–80 years,complete International Federation of Gynecology and Obstetrics(FIGO) stage information,complete information on treatment,and a minimum follow-up of 6 months.Local control(LC) and locoregional control(LRC),overall survival(OS) and disease-free survival(DFS) rates were computed using the Kaplan-Meier method.Univariate analysis was implemented using the log rank test,and multivariate analysis using the Cox model.Results: All patients underwent surgery.Seventy-five patients(68%) received adjuvant radiotherapy(RT),including brachytherapy in 18(16%).Seventeen patients(15%) received adjuvant chemotherapy.Median follow-up was 58(range,6–240) months.Five-year OS and DFS rates were 50% and 34%,and LC and LRC rates were 88%and 72%,respectively.On multivariate analysis,independent favorable prognostic factors were younger age,FIGO stage I,small tumor size,previous uterine disease,and no vascular invasion for OS and DFS.FIGO stage was the only favorable factor influencing LRC.Adjuvant local or systemic treatments did not improve the outcomes.Eight patients treated with RT presented a grade 3 acute toxicity,and only one patient with grade 3 late toxicity.Conclusions: In this large population of primary ULMS patients,we found good results in terms of LC and LRC.Nevertheless,OS remains poor,mainly due to the occurrence of distant metastases.An early diagnosis seemed to improve the prognosis of the patients.Adjuvant local or systemic treatments,or more aggressive surgicalprocedures such as the Wertheim procedure,did not seem to impact the outcome. | Alessandra Franzetti Pellanda Berardino De Bari Elisabeth Deniaud-Alexandre MarcoKrengli Paul Van Houtte Antonella Riehetti Salvador Villa Hadassah Goldberg EwaSzutowiez-Zielifiska Michel Bolla Heidi Rutten Marc Van Eijkeren Philip Poortmans Guido Henke Yavuz Anaeak Steve Chan Christine Landmann Carine Kirkove LueianoScandolaro Jacques Bernier Rene-Olivier Mirimanof Mahmut Ozsahin | 2017 | Chinese Journal of Cancer Research2017，29，6： | 2 |
| 3 | Treating different types of raw water with micro and ultrafiltratioin for further desalination using reverse osmosis 显示文摘 | Emmanuel Van Houtte Johan Vervauwhede Frans Vanlerberghe | 1998 | Desalination1998，117，13： | 1 |
| 4 | S' phase precipitation in A1-4%Mg-1%Cu alloy显示文摘 | RATCHEV P VERL1NDEN B VAN HOUTTE P | 1994 | Scripta Metall1994，30，： | 1 |
| 5 | Assessment of different X-ray stress measuring techniques for thintitanium nitride coatings显示文摘 | SAERENS A VAN HOUTTE P MEERT B OUAEVHAEGENS C | 2000 | J Appl Cryst2000，33，： | 1 |
| 6 | A comprehensive mathematical formulation of an extended Taylor-Bishop-Hill model featuring relaxed constraints, the Renouard-Wintenberger theory and a strain rate sensitivity model 显示文摘 | van HOUTTE P | 1989 | Textures and Microstructures1989，89，： | 1 |
| 7 | Thymoma:a focus on current therapeutic management 显示文摘 | Girard N Momex F Van Houtte P | 2009 | J Thorae Oneol2009，4，1： | 1 |
| 8 | Postoperative radiotherapy for lung cancer显示文摘 | Van Houtte P | 1991 | Lung Cancer1991，7，： | 1 |
| 9 | Large strain work hardening and texture显示文摘 | SEVILLANO J G HOUTTE P V AERNOUDT E | 1980 | Progress in Materials Science1980，25，： | 1 |
| 10 | Respiratory musete training in persons with spinal cord injury: a systematic review 显示文摘 | Van Houtte S Vanlandewijck Y Gosselink R | 2006 | Respir Med2006，100，： | 1 |
| 11 | Quantitative prediction of textures in aluminium cold rolled to moderate strains 显示文摘 | DELANNAY L KALID1NDI S R van HOUTTE P | 2002 | Materials Science and Engineering A2002，336，12： | 1 |
| 12 | The International Association for the Study of Lung Cancer lung cancer staging project : proposals regarding the clinical staging of small cell lung cancer in the forthcoming ( seventh ) edition of the tumor, node, metastasis classification for lung cancer显示文摘 | Shepherd FA Crowley J Van Houtte P | 2007 | J Thorac Oncol2007，2，： | 1 |
| 13 | HACCP to guarantee safe water reuse and drinking water production-a case study显示文摘 | Dewettinck T Van Houtte E Geenens D | 2001 | Water Science Technology2001，43，12： | 1 |
| 14 | M,School Ethnic Composition and Students' Integration Outside and Inside Schools in Belgium 显示文摘 | Van Houtte | 2009 | Sociology of Education2009，，3： | 1 |
| 15 | Texture changes through grain growth in Ti-Bearing IF steel investigated by orientation imaging microscopy and X-Ray diffraction 显示文摘 | Samajdar I Verlinden B Van Houtte P | 1997 | ISIJ Int1997，37，10： | 1 |
| 16 | Large strain work hardening and textures 显示文摘 | SEVILLANO J G HOUTTE P V AERMOUDT E | 1981 | prog Mater Sci1981，25，： | 1 |
| 17 | Assessing the fate of Nitrosamine precursors in wastewater treatment by physieochemical fraction 显示文摘 | Martin Krauss Philipp longr6e Emmanuel van Houtte | 2010 | Environ Sci Technol2010，44，20： | 1 |
| 18 | Production,characterization and in vitro testing of HBcAg-specific VHH intrabodies显示文摘 | Serruys B Van Houtte F Farhoudi-Moghadam A | | 0，，： | 1 |
| 19 | The International Association for the Study of Lung Cancer lung cancer staging project:proposals regarding the clinical staging of small cell lung cancer in the forthcoming(seventh)edition of the tumor,node,metastasis classification for lung cancer显示文摘 | Shepherd FA Crowley J Van Houtte P | 2007 | Thorac Oncol2007，2，12： | 1 |
| 20 | Indications and treat-ment schedules for irradiation of benign diseases:a survey显示文摘 | Leer JW van Houtte P Daelaar J | 1998 | Radiother Oncol1998，48，3： | 1 |
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