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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Quantitation of soybean allergens using tandem mass spectromeey显示文摘 | HOUSTON N L LEE D G STEVENSON S E | 2011 | J Proteome Res2011，10，2： | 1 |
| 3 | GPU computing显示文摘 | Owens J D Houston M Luebke D | | 0，，05： | 1 |
| 4 | GPU Computing显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 5 | 查看详情显示文摘 | Slinker J Bernards D Houston P L | | 0，，： | 1 |
| 6 | t- Linked overrings and Prufer v-multiplication domains显示文摘 | Dobbs D Houston E ucas T | 1989 | Comm Algebra1989，17，： | 1 |
| 7 | Protocol for the assessment of unsaturated soil properties in geotechnical engineering practice显示文摘 | FREDLUND D G HOUSTON S L | 2009 | Canadian Geotechnical Journal2009，46，： | 1 |
| 8 | Sources of error in measurements from cephalometric radiographs显示文摘 | Houston WJ Maher RE McElroy D | 1986 | Eur J Orthod1986，8，3： | 1 |
| 9 | The overall gains from large banking mergers显示文摘 | HOUSTON J F RYNGAERT M D | 1994 | Journal of Banking and Finance1994，18，6： | 1 |
| 10 | GPU Computing 显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 11 | Effect of surface steps on the plastic threshold in nanoindentation显示文摘 | Kiely J D Hwang R Q Houston J E | 1998 | Physical review letters1998，81，： | 1 |
| 12 | Impaired brachial artery endothelial function is not predicted by elevated triglycerides显示文摘 | Schnell GB Robertson A Houston D | 1999 | J Am Coil Cardiol1999，33，7： | 1 |
| 13 | Sleep apnea syndrome and essential hypertension显示文摘 | Wiiliams AJ Houston D Finberg S | 1985 | Am J Cardiol1985，55，8： | 1 |
| 14 | The Shlft-Share Analysis of Regional growth: A Critique显示文摘 | Houston D | 1967 | The Southern Economic Journal1967，，34： | 1 |
| 15 | Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo显示文摘 | Houston A Walsron-Lynch F D Bennett M N et aI | 2003 | Int J Cancer2003，1，10： | 1 |
| 16 | Cancellation and focus:The Role of Shared and Unique Features in the Choice Process显示文摘 | HOUSTON D A SHERMAN S T | 1995 | Journal of Experimental Social Psychology1995，31，4： | 1 |
| 17 | A new look at anchoring effects: Basic anchoring and its antecedents 显示文摘 | Wilson T D Houston C E Eitling K M | 1996 | Journal of Experimental psychology : General1996，125，4： | 1 |
| 18 | Brook for GPUs:Stream computing on graphics hardware显示文摘 | Buck I Foley T Horn D R Sugerman J Fatahalian K Houston M Hanrahan P | | 0，，03： | 1 |
| 19 | Feature Matching,Unique Features,and the Dynamics of the Choice Process:Predecision Conflict and Postdecision Satisfaction显示文摘 | HOUSTON D A SHERMAN S T BAKER S M | 1991 | Journal of Experimental Social Psychology1991，27，5： | 1 |
| 20 | A polymor phism in the 5'-Untranslated region of the porcine cholecys- tokinin type A receptor gene affects feed in take and growth 显示文摘 | Houston R D Haley C S Archibald A L | 2006 | Genetics Sociaety of America2006，10，： | 1 |
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