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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | A closer look at GPUs显示文摘 | Fatahalian K Houston M | 2008 | Communica- tions of the ACM2008，1，： | 1 |
| 3 | Comparison of ultrasound with fluoroscopy in the assessment of suspected hemidiaphragmatic movement abnormality显示文摘 | Houston JG Fleet M Cowan MD | 1995 | Clin Radiol1995，50，2： | 1 |
| 4 | A filarial nematode-secreted product signals dendritic cells to acquire a phenotype that drives development of Th2显示文摘 | Whelannn M Harnett MM Houston KM | 2000 | J Immunol2000，164，12： | 1 |
| 5 | Evolutionarily stable levels of vigilance as a function of group size 显示文摘 | MCNAMARA J M HOUSTON A I | 1992 | Animal Behaviour1992，43，： | 1 |
| 6 | GPU computing显示文摘 | Owens J D Houston M Luebke D | | 0，，05： | 1 |
| 7 | Surface leakage currents in SiN passivated AIGaN/GaN HFETs 显示文摘 | TAN W S UREN M J HOUSTON P A | 2006 | IEEE Electron Device Letters2006，27，1： | 1 |
| 8 | GPU Computing显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 9 | Exemplars or Beliefs? The Impact of Self- view on the Nature and Relative Influence of Brand Associations 显示文摘 | Ng S Houston M J | 2006 | Journal of Consumer Research2006，32，4： | 1 |
| 10 | Field Dependency and Brand Cognitive Structures 显示文摘 | Ng S Houston M J | 2009 | Journal of Marketing Research2009，46，2： | 1 |
| 11 | Fluorescence-enhanced, near infrared diagnostic imaging with contrast agents显示文摘 | Eva M Sevick-Muraca Jessica P Houston Michael Gurfinkel | 2002 | Current Opinion in Chemical Biology2002，，5： | 1 |
| 12 | A comparison of nutrient sources and behaviour in two lowland subcatchments of the River Wye显示文摘 | Houston J A Brooker M P | | 0，，： | 1 |
| 13 | The overall gains from large banking mergers显示文摘 | HOUSTON J F RYNGAERT M D | 1994 | Journal of Banking and Finance1994，18，6： | 1 |
| 14 | GPU Computing 显示文摘 | Owens J D Houston M Luebke D | 2008 | Proceedings of the IEEE2008，96，5： | 1 |
| 15 | Marfan syndrome and aortic dissection in pregnancy显示文摘 | Houston L Tuuli M Macones G | 2011 | J Obstet Gynecol2011，117，4： | 1 |
| 16 | Fas ligand expressed in colon cancer is not associated with increased apoptosis of tumor cells in vivo显示文摘 | Houston A Walsron-Lynch F D Bennett M N et aI | 2003 | Int J Cancer2003，1，10： | 1 |
| 17 | Statins and C-reactive protein levels显示文摘 | Asher J Houston M | 2007 | Clin Hypertens(Greenwich)2007，9，8： | 1 |
| 18 | A new look at anchoring effects: Basic anchoring and its antecedents 显示文摘 | Wilson T D Houston C E Eitling K M | 1996 | Journal of Experimental psychology : General1996，125，4： | 1 |
| 19 | Brook for GPUs:Stream computing on graphics hardware显示文摘 | Buck I Foley T Horn D R Sugerman J Fatahalian K Houston M Hanrahan P | | 0，，03： | 1 |
| 20 | Feature Matching,Unique Features,and the Dynamics of the Choice Process:Predecision Conflict and Postdecision Satisfaction显示文摘 | HOUSTON D A SHERMAN S T BAKER S M | 1991 | Journal of Experimental Social Psychology1991，27，5： | 1 |
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