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55篇 您的检索式：作者名="Hooyman"

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	题名	作者	年代	出处	被引量
1	On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials.	Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong	2005	World Journal of Gastroenterology2005，11，35：	4
2	On the Bose-Einstein condensation显示文摘	DEGROOT S R HOOYMAN G J TEN SELDAM C A	1950	Proc R Soc London Ser A1950，203，22：	1
3	Caregiving and the experience of subjective and objective burden显示文摘	Montgomery RJV Gonyea JG Hooyman NR	1985	Family Relations1985，43，：	1
4	Prevention of posterior capsu- lar opacification显示文摘	NIBOURG LM GELENS E KUIJER R HOOYMANS JM VAN KOOTEN TG KOOPMANS SA	2015	Exp Eye Res2015，136，7：	1
5	Idiopathicepiretinal membrane显示文摘	BU SG KUIJER R LIXR HOOYMANS JM LOS U	2014	Retina2014，34，12：	1
6	Postoperative An- algesia requirements at home arter inguinal hernia repair: effects of wound infiltration on postoperative pain显示文摘	Ausems ME Hulsewe KW Hooymans PM	2007	Anaesthesia2007，62，4：	1
7	Caregiving and the experience of subjective and objective burden 显示文摘	Montgomery R J Gonyea J G Hooyman N R	1985	Fam Relat1985，34，1：	1
8	An- tidepressiva: preparaat keuze door middel van de SO- JA method显示文摘	Janknegt R Hoes MJAJM Hooymans PM etal	2001	Modern Med2001，25，：	1
9	Effects of absorption enhancers on human nasal tissue ciliary movement in vitro显示文摘	Hermens WAJJ Hooymans PM Verhoef JC	1990	Pharm Res1990，7，2：	1
10	Effects of absorption enhancers on human nasal tissue ciliary movement in vitro显示文摘	HERMENSW A J J HOOYMANS P M VERHOES J C	1990	Pharm Res1990，7，2：	1
11	Caregi- ving and the experience of subjective and objective burden 显示文摘	Montgomery R J Gonyea J G Hooyman N R	1985	Faro Relat1985，34，1：	1
12	Caregiving and the experience of subjective and objective burden显示文摘	Montgomery RJV Gonyea JG Hooyman N1k	1985	Family Relations1985，34，1：	1
13	Straylight measurements in pseudophakic eyes with natural and dilated pupils:one-year follow-up显示文摘	Vail Gaalen Kw Koopmans SA Hooymans JM		0，，06：	1
14	Caregiving and experience of subjective and objective burden显示文摘	Montgomery R Gonyea J G Hooyman N R	1985	Family Relations1985，34，1：	1
15	Formation of proliferative vitreoretinopathy in primary rhegmatogenous retinal detachment 显示文摘	Hooymans JM de Lavalette VW Oey AG	2000	Doc Ophthalmol2000，100，：	1
16	Caregiving and the experience of subjective and objectiveburden显示文摘	Montgomery RJV Gonyea JG Hooyman NR	2009	Family Relations2009，34，1：	1
17	Myelinated nervefibers and retinal vascular abnormalities显示文摘	Leys AM Leys MJ Hooymans JM	1996	Retina1996，16，2：	1
18	Minimizing drilling surprises in deepwater goal of 'live' drilling plan 显示文摘	Hooyman P Plumb R Bordelon D	2001	Offshore2001，61，10：	1
19	Caregiving and the experience of subjective and objective burden显示文摘	Montgomery RJV Ganyea JG Hooyman NR	1985	Family Relations1985，43，：	1
20	Recurrent toxic hepa-titis in a Cau casian girl related to the use of Shou Wu Pian, aChinese herb alpreparat ion 显示文摘	Panis B Wong DR Hooymans PM	2005	J Pediatr Gastroenterol Nutr2005，41，2：	1

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