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| 1 | Matrix metalloproteinases contribute to kidney fibrosis in chronic kidney diseases显示文摘Matrix metalloproteinases(MMPs) are members of the neutral proteinase family. They were previously thought to be anti-fibrotic because of their ability to degrade and remodel of extracellular matrix. However, recent studies have shown that MMPs are implicated in initiation and progression of kidney fibrosis through tubular cell epithelial–mesenchymal transition(EMT) as well as activation of resident fibroblasts, endothelial-mesenchymal transition(Endo MT) and pericyte-myofibroblast transdifferentiation. Interstitial macrophage infiltration has also been shown to correlate with the severity of kidney fibrosis in various chronic kidney diseases. MMPs secreted by macrophages, especially MMP-9, hasbeen shown by us to be profibrotic by induction of tubular cells EMT. EMT is mainly induced by transforming growth factor-β(TGF-β). However, MMP-9 was found by us and others to be up-regulated by TGF-β1 in kidney tubular epithelial cells and secreted by activated macrophages, resulting in EMT and ultimately kidney fibrosis. Therefore, MMP-9 may serve as a potential therapeutic target to prevent kidney fibrosis in chronic kidney disease. This review, by a particular focus on EMT, seeks to provide a comprehensive understanding of MMPs, especially MMP-9, in kidney fibrosis. | Hong Zhao Yanting Dong Xinrui Tian Thian Kui Tan Zhuola Liu Ye Zhao Yun Zhang David CH Harris Guoping Zheng | 2013 | World Journal of Nephrology2013，2，3： | 21 |
| 2 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 3 | A MUCLTI-PARAMETER SPLITTING EXTRAPOLATION AND A PARALLEL ALGORITHM显示文摘The finite element solutions of elliptic equations are shown to have a multiparameter asymptotic error expansion. Based on this expansion and a multi-parametersplitting extrapolation technique, a parallel algorithm for solving multi-dimensional equations with high order accuracy is introduced. | ZHOU Aihui(Institute of Systems Science, Academia Sinica, Beijing 100080, China)Liem Chin-ho Shih Tsi-min(Department of Applied Mathematics, Hong Kong Polytechnic University, Hong Kong)LU Tao(Institute of Chengdu Computer Application, Academia Sinica, Ch | 1997 | Systems Science and Mathematical Sciences1997，10，3： | 8 |
| 4 | Micronuclei in Nasal Mucosa, Oral Mucosa and Lymphocytes in Students Exposed to Formaldehyde Vapor in Anatomy Class显示文摘The frequency of micronuclei (MN) in cells of the nasal mucosa, oral mucosa and in lym-phocytes was evaluated for 25 students in anatomy classes exposed to formaldehyde (FA) overan 8-week period. Each student served as his or her own control. The time-weighted averageconcentration (TWA) of fOrmaldehyde in anatomical laboratories and in students’ dormitorieswas 0. 508 ± 0. 299 mg/m3 and 0. 012 ± 0. 0025mg/m3, respectively. A higher frequency ofmicronuclei was observed in nasal and oral exfoliative cells after formaldehyde exposure (3. 85± 1. 48 vs 1 .20± 0. 676 and 0. 857 ± 0. 558 vs 0. 568 ± 0. 317, paired-t test: P< 0. 001and P < 0. 01, respectively). No significant increase in the frequency of lymphocyte micronu-clei was found after formaldehyde exposure (P >0. 05 ). The present study shows that nasalmucosa cel1s exposed through respiration are the chief target of FA-induced genotoxic | YING CHEN -JlANG YAN WEN-SHENG ZHAO MEI-YING YE XIAO-LEI XIE HONG YIN SHU-YI ZHU XIAN-SHU(Department of Environmental Health, n Dgurtment of Anatomy,Tongji the ical University, Wuhan, China)(Department of Public Health, Wengzhou theical Chllege, Ch | 1997 | Biomedical and Environmental Sciences1997，10，4： | 7 |
| 5 | Synthesis of the Complex Fluoride LiBaF_(3) through a Solvothermal Process显示文摘The complex fluoride LiBaF3 is solvothermally synthesized at 180℃ and characterized by means of X-ray powder diffraction, scanning electron microscopy, thermogravimetric analysis and infrared spectroscopy. In the solvothermal process, the solvents, mole ratios of initial mixtures and reaction temperature play important roles in the growth of the single crystal. | Rui Nian HUA1, Zhi Hong JIA2, De Min XIE1, Chun Shan SHI2* 1Faculty of Chemistry, Northeast Normal University, Changchun 130024 2Key Laboratory of Rare Earth Chemistry and Physics, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Ch | 2002 | Chinese Chemical Letters2002，13，10： | 2 |
| 6 | Healing effects of heparin on acetic acid-induced gastric ulcers in rats显示文摘HealingefectsofheparinonaceticacidinducedgastriculcersinratsYangLi,QiBingMeiandChiHinChoDepartmentofPharmacology,FacultyofMe... | Yang Li, Qi Bing Mei and Chi Hin Cho Department of Pharmacology, Faculty of Medicine, The University of Hong Kong, 5 Sassoon Road, Hong Kong (Li Y, Mei QB and Cho CH) | 1998 | Chinese Medical Journal1998，，1： | 2 |
| 7 | randomized trial of neoadjuvant cisplatin,vincristine,bleomyin,and radical hysterectomy versus radiation therapy for bulky stage I B and II A cervical cancer 显示文摘 | Chang TC Lai CH Hong JH | 2000 | Chn Oncol2000，18，8： | 1 |
| 8 | Structural and functional character- ization of the 5 '-upstream promoter factor Phox2b 显示文摘 | Hong S J Kim CH Kim KS | 2001 | J Neu- rochem2001，79，6： | 1 |
| 9 | GSK-313 activity in the hippocampus is required for memory retrieval 显示文摘 | Hong JG Kim DH Lee CH | 2012 | Neurobiol Learn Mem2012，98，2： | 1 |
| 10 | Comparison of four molecular typing methods for the differentiation of Salmonella spp显示文摘 | Lim H Lee KH Hong CH | 2005 | Int J Food Microbiol2005，105，： | 1 |
| 11 | Camparison of singleand multiple sessions of percutaneous sclerotherapy of simplerenal cysts显示文摘 | Chung BH Kin JH Hong CH | 2000 | BJU Int2000，85，6： | 1 |
| 12 | A new image encryption scheme based on Hyper-chaotic sequences 显示文摘 | LI CH M HONG L X | 2007 | IEEE International Workshop on Anti-counterfeiting Security Identification2007，，： | 1 |
| 13 | Management of severe bilateral ureteropelvic junction obstruction in neonates with pronatally diagnosed bilate-ral hydronephrosis显示文摘 | Kim J Hong S Park CH | 2010 | Korean J Urol2010，51，9： | 1 |
| 14 | The inhibitory effect of interleukin 10 on mouse osteoclast formation involves no- vel tyrosine- phosphorylated proteins 显示文摘 | Hong MH Williams H Jin CH | 2000 | J Bone Miner Res2000，15，5： | 1 |
| 15 | Comparison of single and multiple sessions of pereutaneous sclerotherapy for simple renal cyst 显示文摘 | Chung BH Kim JH Hong CH | 2000 | BJUInt2000，85，： | 1 |
| 16 | Does every patient with ureteropelvis junction obstruction need voiding cystourethrography显示文摘 | Kim YS Do SH Hong CH | 2001 | J Urol2001，165，62： | 1 |
| 17 | Multicriteria fuzzy decision--making problems based on vague set theory显示文摘 | Hong D H Choi CH | 2000 | Fuzzy Sets and Systems2000，114，1： | 1 |
| 18 | Effects of FFA on insulin-stimulated glucose fluxes and muscle glycogen synthase activity in rats显示文摘 | Kim CH Hong SR | 1998 | Am J Physiol1998，275，2： | 1 |
| 19 | Aerobic plate counts as a measure of hazard analys is critical control point effectiveness in a pork processing plant 显示文摘 | Hong CH Todd EC Bahk GJ | 2008 | J Food Prot2008，71，： | 1 |
| 20 | Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratinocytes显示文摘 | Kok SH Hong CY Kuo MY Lee CH Lee JJ Lou IU | 2003 | Oral Oncol2003，39，1： | 1 |
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