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| 1 | Are probiotics useful in Helicobacter pylori eradication?显示文摘Helicobacter pylori(H. pylori) is considered an etiologic factor for the development of peptic ulcer disease,gastric adenocarcinoma, and MALT lymphoma.Therapeutic schemes to eradicate the bacteria are based on double antibiotic therapy and proton pump inhibitor. Despite many therapeutic improvements in H. pylori eradication treatment, it is still associated with high infection rate also in developed countries.Bacterial resistance and adverse events occurrence are among most frequent causes for anti- H. pylori treatment failure. Several studies have reported that certain probiotic strains can exhibit inhibitory activity against H. pylori bacteria. In addition, some probiotic strains can reduce the occurrence of side effects due to antibiotic therapy and consequently increase the H.pylori eradication rate. The results of the prospective double-blind placebo-controlled studies suggest that specific probiotics, such as S. boulardii and L.johnsonni La1 probably can diminish the bacterial load,but not completely eradicate the H. pylori bacteria.Furthermore, it seems that supplementation with S. boulardii is a useful concomitant therapy in the standard H. pylori eradication treatment protocol and most probably increases eradication rate. L. reuteri is equally effective, but more positive studies are needed. Finally, probiotic strains, such as S. boulardii,L. reuteri and L. GG, decrease gastrointestinal antibiotic associated adverse effects. | Matjaz Homan Rok Orel | 2015 | World Journal of Gastroenterology2015，21，37： | 29 |
| 2 | Helicobacter pylori virulence genes显示文摘Helicobacter pylori(H.pylori)is one of the most important human pathogens,infecting approximately half of the global population.Despite its high prevalence,only a subset of H.pylori infected individuals develop serious gastroduodenal pathology.The pathogenesis of H.pylori infection and disease outcome is thus thought to be mediated by an intricate interplay between host,environmental and bacterial virulence factors.H.pylori has adapted to the harsh milieu of the human stomach through possession of various virulence genes that enable survival of the bacteria in the acidic environment,movement towards the gastric epithelium,and attachment to gastric epithelial cells.These virulence factors enable successful colonization of the gastric mucosa and sustain persistent H.pylori infection,causing chronic inflammation and tissue damage,which may eventually lead to the development of peptic ulcers and gastric cancer.Numerous studies have focused on the prevalence and role of putative H.pylori virulence genes in disease pathogenesis.While several virulence factors with various functions have been identified,disease associations appear to be less evident,especially among different study populations.This review presents key findings on the most important H.pylori virulence genes,including several bacterial adhesins and toxins,in children and adults,and focuses on their prevalence,clinical significance and potential relationships. | Anja Sterbenc Erika Jarc Mario Poljak Matjaz Homan | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 3 | Abernethy syndrome in Slovenian children: Five case reports and review of literature显示文摘BACKGROUND Abernethy syndrome is a congenital vascular anomaly in which the portal blood completely or partially bypasses the liver through a congenital portosystemic shunt.Although the number of recognized and reported cases is gradually increasing,Abernethy syndrome is still a rare disease entity,with an estimated prevalence between 1 per 30000 to 1 per 50000 cases.With this case series,we aimed to contribute to the growing knowledge of potential clinical presentations,course and complications of congenital portosystemic shunts(CPSS)in children.CASE SUMMARY Five children are presented in this case series:One female and four males,two with an intrahepatic CPSS and three with an extrahepatic CPSS.The first patient,who was diagnosed with an intrahepatic CPSS,presented with gastrointestinal bleeding,abdominal pain and hyperammonaemia at six years of age.He underwent a percutaneous embolization of his shunt and has remained asymptomatic ever since.The second patient presented with direct hyperbilirubinemia in the neonatal period and his intrahepatic CPSS later spontaneously regressed.The third patient had pulmonary hypertension and hyperammonaemia due to complete portal vein agenesis and underwent liver transplantation at five years of age.The fourth patient was diagnosed immediately after birth,when evaluated due to another congenital vascular anomaly,and the last patient presented as a teenager with recurrent bone fractures associated with severe osteoporosis.In addition,the last two patients are characterised by benign liver nodules;however,they are clinically stable on symptomatic therapy.CONCLUSION Abernethy syndrome is a rare anomaly with diverse clinical features,affecting almost all organ systems and presenting at any age. | Jerneja Pecek Petja Fister Matjaz Homan | 2020 | World Journal of Gastroenterology2020，26，37： | 6 |
| 4 | Enzyme-amplified SERS immunoassay with Ag-Au bimetallic SERS hot spots显示文摘Surface-enhanced Raman scattering(SERS)enables rapid detection of single molecules with high specificity.However,quantitative and sensitive SERS analysis has been a challenge due to the lack of reliable SERS-active materials.In this study,we developed a quantitative SERS-based immunoassay using enzyme-guided Ag growth on Raman labeling compound(RLC)-immobilized gold nanoparticle(Au NP)-assembled silica NPs(SiO2@Au-RLC@Ag).The enzyme amplified Ag+reduction as well as Ag growth on the RLC-immobilized Au NP-assembled silica NPs(SiO2@Au-RLC),which resulted in a significant increase in SERS signal.In the presence of target antigens such as immunoglobulinG(IgG)or prostate-specific antigen(PSA),Ab1-Antigen-Ab2 immune complex with alkaline phosphatase triggered an enzyme-catalyzed reaction to convert 2-phospho-L-ascorbic acid(2-phospho-L-AA)to ascorbic acid(AA).As produced AA reduced Ag+to Ag,forming an Ag hot spot on the surface of SiO2@Au-RLC,which enhanced the SERS signal of SiO2@Au-RLC@Ag in a solution with a target antigen concentration.The plasmonic immunoassay for IgG detection showed a high linearity of SERS intensity in the range of 0.6 to 9.0 ng/mL with a detection limit(LOD)of 0.09 ng/mL,while an LOD of 0.006 ng/mL was obtained for PSA.The results indicate that the sensitivity of our novel SERS-based immunoassay is higher than that of conventional enzyme-based colorimetric immunoassays. | Xuan-Hung Pham Eunil Hahm Tae Han Kim Hyung-Mo Kim Sang Hun Lee Sang Chul Lee Homan Kang Ho-Young Lee Dae Hong Jeong Hak Soo Choi Bong-Hyun Jun | 2020 | Nano Research2020，13，12： | 2 |
| 5 | Effect of atrial natriuretic peptide on coronary collateral blood flow 显示文摘 | Foreman B Dai XZ Homans DC | 1989 | Cite Res1989，65，6： | 1 |
| 6 | Acute exacerbations of chronic obstructive pulmonary disease and mechanical ventilation: a reevaluation 显示文摘 | Moran JL Green JV Homan SD | 1998 | Crit Care Med1998，26，1： | 1 |
| 7 | Comparison of the internal transcribed spacer, ITS 1, from Toxo-plasma gondii isolates and Neospora caninum 显示文摘 | Homan W L Limper L Verlaan M | 1997 | Parasitol Res1997，83，： | 1 |
| 8 | A fluores- cence method to detect and quantitate sterol esterification by lecithin : cholesterol acyltransferase 显示文摘 | Homan R Esmaeil N Mendelsohn L | 2013 | Anal Biochem2013，441，1： | 1 |
| 9 | Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo显示文摘 | Hoshino T Nakaya T Homan T | 2007 | J Biol Chem2007，282，32： | 1 |
| 10 | Prevalence of the Helicobacter pylori babA2 gene and correlation with the degree of gastritis in infected Slovenian children显示文摘 | Matja? Homan Anja ?terbenc Bo?tjan J. Kocjan Bo?tjan Luzar Nina Zidar Rok Orel Mario Poljak | 2014 | Antonie van Leeuwenhoek2014，，4： | 1 |
| 11 | Genistein acutely stimulates nitric oxide synthesis in vascular endothelial cells by a cyclic AMP dependent mechanism显示文摘 | Liu D Homan LL Dillon JS | 2004 | Endocrinology2004，145，12： | 1 |
| 12 | Bridging Faultlines by Valuing Diversity: Diversity Beliefs, Information Elaboration,and Performance in Diverse Work Groups 显示文摘 | HOMAN A C VAN KNIPPENBERG D VAN KLEEF G A | 2007 | Journal of Applied Psychology2007，92，5： | 1 |
| 13 | Perioperative treatment with iv ketoprofen reduces pain and vomiting in children after strabismus surgery显示文摘 | Kokki H Homan E Tuovinen K | 1999 | Acta Anaesthesiol scand1999，43，1： | 1 |
| 14 | To reflect or not to reflect: Prior team performance as a bound- ary condition of the effects of reflexivity on learning and final team performance 显示文摘 | SCHIPPERS M C HOMAN A C VAN KNIPPENBERG D | 2013 | Journal of Organization Behavior2013，，： | 1 |
| 15 | Effect of mindfulness based stress management on reduction of generalized anxiety disorder 显示文摘 | Asmaee Majid SA Seghatoleslam T Homan H | 2012 | Iran J Public Heahh2012，41，10： | 1 |
| 16 | Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting 显示文摘 | Horn CC Wallisch WJ Homanics GE | 2014 | Eur J Pharmaeol2014，722，： | 1 |
| 17 | Acute exacerbations ofchronic obstructive pulmonary disease and mechanical ventilation: areevaluation显示文摘 | Moran JL Green JV Homan SD | 1998 | Crit Care Med1998，26，1： | 1 |
| 18 | 冠状动脉搭桥术早期并发症及死亡率(附196例报告)显示文摘1985年1月~1987年12月作者于荷兰格罗宁根医学科学院心胸外科主做了196例冠状动脉搭桥术。术后早期死亡2例(1.0%)、内出血3例(1.5%)、胸骨裂开2例(1.0%)、心律紊乱40例(20.4%)、围手术期心肌梗塞5例(2.6%),本文就术后早期并发症进行了讨论。 | 王凤林 JN HOMAN VD HElDE | 1990 | 中日友好医院学报1990，4，2： | 1 |
| 19 | The implementation and use of e - learning in the corporate u-niersity 显示文摘 | ALI EN MACPHERSON GILL HOMAN KRYSTAL WILKIN- SON | 2005 | The Journal of Workplace Leam(ng2005，17，12： | 1 |
| 20 | Tuberculosis of the soleus muscle in a fifteen year-old boy显示文摘 | Ahmed J Homans J | 2002 | Pediatr Infect Dis J2002，21，12： | 1 |
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