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| 1 | Treatment quality and outcome for multidrug-resistant tuberculosis patients in four regions of China: a cohort study显示文摘Background:China incurs an extremely low treatment coverage of multidrug-resistant tuberculosis(MDR-TB).This study aimed to understand the experience of MDR-TB patients on quality of health care,and the clinical impact through an up to six-year follow-up.Methods:Cohorts of MDR-TB patients were built in TB/MDR-TB designated hospitals in four regions of China from 2014 to 2015.Patients were followed up during treatment course,and yearly confirmation afterward until 2019.Delay in MDR-TB diagnosis and treatment was calculated upon bacteriological confirmation and treatment initiation.Risk factors for unfavourable outcomes were identified by multivariate logistic regression.Results:Among 1168 bacteriological-positive TB patients identified from a 12-million population,58(5.0%)MDR-TB cases were detected.The median delay for MDR-TB diagnosis was 90.0 days,with 13.8%having a delay above 180.0 days.MDR-TB treatment was only recommended to 19(32.8%)participants,while the rest continued with regimen for drug-susceptible TB.In MDR-TB treatment group,36.8%achieved treatment success,while the others had incomplete treatment(21.1%),loss to follow-up(36.8%)and TB relapse(5.3%).For non-MDR-TB treatment group,33.3%succeeded,25.6%relapsed,2.6%failed,23.1%died,and 15.4%were lost to follow-up.Overall,only 35.7%(20/56)of detected MDR-TB patients had favourable outcomes and higher education level was positively associated with it(adjusted odds ratio[aOR]:3.60,95%confidence interval[CI]:1.04-12.5).Conclusions:A large proportion of patients did not receive MDR-TB treatment and had unfavourable outcomes.Delayed MDR-TB diagnosis resulted in poor quality of MDR-TB care.Rapid diagnosis,regulated patient management and high-quality MDR-TB treatment should be enhanced in China. | Xu-Bin Zheng Vinod K.Diwan Qi Zhao Yi Hu Judith Bruchfeld Wei-Li Jiang Sven Hoffner Biao Xu | 2020 | Infectious Diseases of Poverty2020，9，4： | 5 |
| 2 | Rising challenge of multidrug-resistant tuberculosis in China:a predictive study using Markov modeling显示文摘Background:Multidrug-resistant tuberculosis(MDR-TB)is on the rise in China.This study used a dynamic Markov model to predict the longitudinal trends of MDR-TB in China by 2050 and to assess the effects of alternative control measures.Methods:Eight states of tuberculosis transmission were set up in the Markov model using a hypothetical cohort of 100000 people.The prevalence of MDR-TB and bacteriologically confirmed drug-susceptible tuberculosis(DS-TB+)were simulated and MDR-TB was stratified into whether the disease was treated with the recommended regimen or not.Results:Without any intervention changes to current conditions,the prevalence of DS-TB+was projected to decline 67.7%by 2050,decreasing to 20 per 100000 people,whereas that of MDR-TB was expected to triple to 58/100000.Furthermore,86.2%of the MDR-TB cases would be left untreated by the year of 2050.In the case where MDR-TB detection rate reaches 50%or 70%at 5%per year,the decline in prevalence of MDR-TB would be 25.9 and 36.2%respectively.In the case where treatment coverage was improved to 70%or 100%at 5%per year,MDR-TB prevalence in 2050 would decrease by 13.8 and 24.1%,respectively.If both detection rate and treatment coverage reach 70%,the prevalence of MDR-TB by 2050 would be reduced to 28/100000 by a 51.7%reduction.Conclusions:MDR-TB,especially untreated MDR-TB,would rise rapidly under China’s current MDR-TB control strategies.Interventions designed to promote effective detection and treatment of MDR-TB are imperative in the fights against MDR-TB epidemics. | Bing-Ying Li Wen-Pei Shi Chang-Ming Zhou Qi Zhao Vinod K Diwan Xu-Bin Zheng Yang Li Sven Hoffner Biao Xu | 2020 | Infectious Diseases of Poverty2020，9，3： | 3 |
| 3 | Cross flow:cross organizational workflow management in dynamic virtual enterprises显示文摘 | ABERER K HOFFNER Y | 2000 | International Journal of Computer Systems Science & Engineering2000，15，5： | 1 |
| 4 | Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy显示文摘 | Munter MW Karger CP Hoffner SG | 2004 | Int J Radiat Oncol Biol Phys2004，58，1： | 1 |
| 5 | Contract-driven creation and operation of virtual enterprise 显示文摘 | Hoffner Y Field S | 2001 | Computer Networks2001，37，2： | 1 |
| 6 | Prevalence of muhidrug-resistant pulmonary tuberculosis in counties with different duration of DOTS implementation in rural China 显示文摘 | Yi Hu Barun Mathema Weibing Wang Sven Hoffner Barry Kreiswirth Biao Xu | 2008 | Microb Drug Resist2008，14，： | 1 |
| 7 | Changes in sali- vary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy:compari- son of intensity-modulated radiotherapy and conventional radi- ation therapy with and without amifostine 显示文摘 | MUNTER M W HOFFNER S HOF H | 2007 | Int J Radiat On- col Bio Phys2007，67，3： | 1 |
| 8 | Direct susceptibility testing for multi drug resistant tubereulosis: A meta-analysis显示文摘 | Freddie Bwanga Sven Hoffner Melles Haile Moses L Joloba | 2009 | BMC Infect Dis2009，9，： | 1 |
| 9 | Prevalence and genetic characterization of second- line drug resistant and extensively drug- resistant Myco- bacterium tuberculosis in Rural China 显示文摘 | Hu Y Hoffner S Wu L | 2013 | Antimicrob Agents Che- mother2013，57，8： | 1 |
| 10 | Prevalence and Genetic Characterization of Second-Line Drug-Resistant and Extensively Drug-Resistant Mycobacterium tuberculosis in Rural China显示文摘 | Hu Y Hoffner S Wu L | 2013 | Antimicrob Agents Chemother2013，57，8： | 1 |
| 11 | Pyrazinamide resistance in Swedish muhidrug-resistant tuberculosis 2003-2013 显示文摘 | Mansjfi M Werngren J Hoffner S | 2015 | Interna- tional Journal of Mycobacteriology2015，4，1： | 1 |
| 12 | Successful ventricular defibrillation by the selective sodium-hydrogen exchanger isoform-1 inhibitor cariporide显示文摘 | Gazmuri RJ Ayoub IM Hoffner E | 2001 | Circulation2001，104，2： | 1 |
| 13 | Direct susceptibility testing for multi drug resistant tuberculosis: a meta - analysis 显示文摘 | Bwanga F Hoffner S Halle M | 2009 | BMC Infect Dis2009，9，： | 1 |
| 14 | Direct susceptibility testing for multi drug resistant tuberculosis:a meta-analysis显示文摘 | Bwanga F Hoffner S Haile M | 2009 | BMC In- fect Dis2009，9，1： | 1 |
| 15 | Myocardial protection during ventricular fibrillation by reduction of proton-driven sarcolemmal sodium influx 显示文摘 | Gazmuri RJ Hoffner E Kalcheim J | 2001 | J Lab Clin Med2001，137，1： | 1 |
| 16 | Rapid and inexpensive drug susceptibility festing of Myeobacterium tuberculosis with fl nitrate reductase assay显示文摘 | Angeby K A Klintz L Hoffner S E | 2002 | J Clin Microbio12002，40，2： | 1 |
| 17 | Origin and primary dispersal of the Mycobacterium tuberculosis Beijing genotype:clues from human phylogeography显示文摘 | Mokrousov I Ly HM Otten T Lan NN Vyshnevskyi B Hoffner S Narvskaya O | 2005 | Genome Res2005，15，10： | 1 |
| 18 | Changes in salivary gland function after radiotherapy of head and neck tumors meas- ured by quantitative pertechnetate scintigraphy: Comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine 显示文摘 | Munter MW Hoffner S Hof H | 2007 | Int J Radiat Oncol Bi- ol Phys2007，67，： | 1 |
| 19 | Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity modulated radiotherapy by quantita-tive pertechnetate scintigraphy显示文摘 | Mtinter MW Karger CP Hoffner SG | 2004 | Int J Radiat Oncol Biol Phys2004，58，1： | 1 |
| 20 | 显示文摘 | Gazmuri RJ Ayoub IM Hoffner E | 2001 | Circulation2001，104，2： | 1 |
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