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| 1 | Mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis显示文摘Systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated cholangitis.For steroid-dependent disease,azathioprine has been used for maintenance of remission.Mycophenolate mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte production.Introduction of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse events.The patient was managed without a biliary stent.However,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per day.In the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the steroids.Mycophenolate mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis. | Jamie B Sodikoff Steven A Keilin Sheila J Bharmal Melinda M Lewis Gottumukkala S Raju Field F Willingham | 2012 | World Journal of Gastroenterology2012，18，18： | 6 |
| 2 | Aberrant Th2 inflammation drives dysfunction of alveolar macrophages and susceptibility to bacterial pneumonia显示文摘The ubiquitin ligase,Itch,is required to prevent autoinflammatory disease in mice and humans.Itch-deficient mice develop lethal pulmonary inflammation characterized by the production of Th2 cytokines(for example,interleukin-4(IL-4));however,the contribution of Itch to immune defense against respiratory pathogens has not been determined.We found that Itch-deficient mice were highly susceptible to intranasal infection with the respiratory pathogen Klebsiella pneumoniae.Infected Itch-deficient mice exhibited increased immune cell infiltration,cytokine levels and bacterial burden in the respiratory tract compared with control mice.However,numbers of resident alveolar macrophages were reduced in the lungs from Itch-deficient mice both before and after infection.High levels of Th2 cytokines in the respiratory tract correlated with deceased alveolar macrophages,and genetic ablation of IL-4 restored alveolar macrophages and host defense to K.pneumoniae in Itch-deficient mice,suggesting that loss of alveolar macrophages occurred as a consequence of Th2 inflammation.Adoptive transfer of Itch−/−CD4+T cells into Rag−/−mice was sufficient to drive reduction in numbers of Itch-replete alveolar macrophages.Finally,we found that Stat6 signaling downstream of the IL-4 receptor directly reduced fitness of alveolar macrophages when these cells were exposed to the Itch−/−inflamed respiratory tract.These data suggest that Th2 inflammation directly impairs alveolar macrophage fitness in Itch−/−mice,and elucidate a previously unappreciated link between Th2 cells,alveolar macrophages and susceptibility to bacterial infection. | Emily K Moser Natania S Field Paula M Oliver | 2018 | Cellular & Molecular Immunology2018，15，5： | 2 |
| 3 | The deformation and fracture of β-HMX显示文摘 | Palmer S J P Field J E | 1982 | ProcRSocLondA1982，，： | 1 |
| 4 | The Interaction among Multiple Governance Mechanisms in Young Newly Public Irms 显示文摘 | Tammy K Berry Fields L Paige Wilkins Michael S | 2006 | Journal of Corporate Finance2006，12，3： | 1 |
| 5 | Proteomics in genomeland显示文摘 | Fields S | 2001 | Science2001，291，： | 1 |
| 6 | Enhancement effects on quality characteristics of pork derived from pigs of various commercial genetic backgrounds显示文摘 | Brewer M S Sosnicki A Field B | 2004 | Journal of Food Science2004，69，1： | 1 |
| 7 | A novel genetic system to detect protein-protein interactions显示文摘 | Fields S Song O | 1989 | Nature1989，340，6230： | 1 |
| 8 | A Novel Genetic System to Detect Protein-Protein Interactions 显示文摘 | FIELDS S SONG O | 1989 | Nature1989，340，6230： | 1 |
| 9 | Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30 显示文摘 | Revankar C M Mitchell H D Field A S | 2007 | ACS Chem Biol2007，2，8： | 1 |
| 10 | Neona- tal disease severity scoring systems显示文摘 | DORLING J S FIELD D J MANKTELOW B | 2005 | Arch Dis Child Fetal Neonatal Ed2005，90，： | 1 |
| 11 | Individual differences in servant leadership: The roles of values and personality 显示文摘 | Washington R R Sutton C D Field H S | 2006 | Leadership &Organization Development Journal2006，27，8： | 1 |
| 12 | Primary and repeat surgical treatment for female pelvic organ prolapse and incontinence in parous women in the UK: a register linkage study显示文摘 | Abdel-Fattah M Familusi A Fielding S | 2011 | BMJ Open2011，1，00： | 1 |
| 13 | Power 4 system micro architecture显示文摘 | TENDLER J M DODSON J S FIELDS J S | 2002 | IBM Journal of Research and Development2002，46，1： | 1 |
| 14 | Melt strength ofpolypropylene : its relevance to thermoforming 显示文摘 | LAU H C BHATACHARYA S N FIELD G J | 1998 | PolymerEngineering Science1998，38，11： | 1 |
| 15 | A network of protein-protein interactions in yeast 显示文摘 | Schwikowski B Uetz P Fields S | 2000 | Nat Biotechnol2000，18，： | 1 |
| 16 | Nonlinear optical processes using electromagnetically induced transparency 显示文摘 | HARRIS S E FIELD J E IMAMOGLU A | 1990 | PHYSICAL REVIEW LETTERS1990，64，10： | 1 |
| 17 | Protein-peptide interactions analyzed with the yeast two-hybrid system显示文摘 | Yang M Wu Z Fields S | 1995 | Nucleic Acids Res1995，23，7： | 1 |
| 18 | Presence of potent transcription activating sequence in the p53 protein 显示文摘 | Fields S Jang SK | | Science0，249，4972： | 1 |
| 19 | E2F-1 functions in mice to promote apoptosis and suppress proliferation显示文摘 | FIELD S J TSAI F Y KUO F | 1996 | Cell1996，85，4： | 1 |
| 20 | Performance evaluation of the im- mature granulocyte parameter on the Sysmex XE 2100 automated hematology analyzer显示文摘 | Field D Taube E Heumann S | 2006 | Lab Hematol2006，12，1： | 1 |
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