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| 1 | 为十二指肠的胃肠的 stromal 肿瘤的有限切除术:外科的管理和临床的结果显示文摘 AIM:To analyze our experience in patients with duodenal gastrointestinal stromal tumors(GIST) and review the appropriate surgical approach.METHODS:We retrospectively reviewed the medical records of all patients with duodenal GIST surgically treated at our medical institution between 2002 and 2011.Patient files,operative reports,radiological charts and pathology were analyzed.For surgical therapy open and laparoscopic wedge resections and segmental resections were performed for limited resection(LR).For extended resection pancreatoduodenectomy was performed.Age,gender,clinical symptoms of the tumor,anatomical localization,tumor size,mitotic count,type of resection resectional status,neoadjuvant therapy,adjuvant therapy,risk classification and follow-up details were investigated in this retrospective study.RESULTS:Nine patients(5 males/4 females) with a median age of 58 years were surgically treated.The median follow-up period was 45 mo(range 6-111 mo).The initial symptom in 6 of 9 patients was gastrointestinal bleeding(67%).Tumors were found in all four parts of the duodenum,but were predominantly located in the first and second part of the duodenum with each 3 of 9 patients(33%).Two patients received neoadjuvant medical treatment with 400 mg imatinib per day for 12 wk before resection.In one patient,the GIST resection was done by pancreatoduodenectomy.The 8 LRs included a segmental resection of pars 4 of the duodenum,5 wedge resections with primary closure and a wedge resection with luminal closure by Roux-Y duodeno-jejunostomy.One of these LRs was done minimally invasive;seven were done in open fashion.The median diameter of the tumors was 54 mm(14-110 mm).Using the Fletcher classification scheme,3/9(33%) tumors had high risk,1/9(11%) had intermediate risk,4/9(44%) had low risk,and 1/9(11%) had very low risk for aggressive behaviour.Seven resections showed microscopically negative transsection margins(R0),two showed positive margins(R1).No patient developed local recurrence during follow-up.The one patient who underwent pancreatoduodenectomy died due to progressive disease with hepatic metastasis but without evidence of local recurrence.Another patient died in complete remission due to cardiac disease.Seven of the nine patients are alive disease-free.CONCLUSION:In patients with duodenal GIST,limited surgical resection with microscopically negative margins,but also with microscopically positive margins,lead to very good local and systemic disease-free survival. | Jens Hoeppner Birte Kulemann Goran Marjanovic Peter Bronsert Ulrich Theodor Hopt | 2013 | World Journal of Gastrointestinal Surgery2013，5，2： | 11 |
| 2 | Extracellular matrices for gastrointestinal surgery:Ex vivo testing and current applications显示文摘AIM:To assess the effects of bile and pancreatic juice on structural and mechanical resistance of extracellular matrices(ECMs) in vitro.METHODS:Small-intestinal submucosa(SIS),porcine dermal matrix(PDM),porcine pericardial matrix(PPM) and bovine pericardial matrix(BPM) were incubated in human bile and pancreatic juice in vitro.ECMs were examined by macroscopic observation,scanning electron microscopy(SEM) and testing of mechanical resistance.RESULTS:PDM dissolved within 4 d after exposure to bile or pancreatic juice.SIS,PPM and PDM retained their integrity for > 60 d when incubated in either digestive juice.The effect of bile was found to be far more detrimental to mechanical stability than pancreatic juice in all tested materials.In SIS,the loss of mechanical stability after incubation in either of the digestive secretions was less distinct than in PPM and BPM [mFmax 4.01/14.27 N(SIS) vs 2.08/5.23 N(PPM) vs 1.48/7.89 N(BPM)].In SIS,the extent of structural damage revealed by SEM was more evident in bile than in pancreatic juice.In PPM and BPM,structural damage was comparable in both media.CONCLUSION:PDM is less suitable for support of gastrointestinal healing.Besides SIS,PPM and BPM should also be evaluated experimentally for gastrointestinal indications. | Jens Hoeppner Goran Marjanovic Peter Helwig Ulrich Theodor Hopt Tobias Keck | 2010 | World Journal of Gastroenterology2010，16，32： | 2 |
| 3 | Impact of remote ischemic preconditioning on wound healing in small bowel anastomoses显示文摘AIM: To investigate the influence of remote ischemic preconditioning (RIPC) on anastomotic integrity. METHODS: Sixty male Wistar rats were randomized to six groups. The control group (n = 10) had an end-to-end ileal anastomosis without RIPC. The preconditioned groups (n = 34) varied in time of ischemia and time of reperfusion. One group received the amino acid L-arginine before constructing the anastomosis (n = 9). On postoperative day 4, the rats were re-laparotomized, and bursting pressure, hydroxyproline concentration, intra-abdominal adhesions, and a histological score concerning the mucosal ischemic injury were collected. The data are given as median (range).RESULTS: On postoperative day 4, median bursting pressure was 124 mmHg (60-146 mmHg) in the control group. The experimental groups did not show a statistically significant difference (P > 0.05). Regarding the hydroxyproline concentration, we did not find any significant variation in the experimental groups. We detected significantly less mucosal injury in the RIPC groups. Furthermore, we assessed more extensive intra-abdominal adhesions in the preconditioned groups than in the control group. CONCLUSION: RIPC directly before performing small bowel anastomosis does not affect anastomotic stability in the early period, as seen in ischemic preconditioning. | Philipp Anton Holzner Birte Kulemann Simon Kuesters Sylvia Timme Jens Hoeppner Ulrich Theodor Hopt Goran Marjanovic | 2011 | World Journal of Gastroenterology2011，17，10： | 2 |
| 4 | Prior corrosion and fatigue of 2024-T3 aluminum alloy显示文摘 | Kimberli Jones David W. Hoeppner | 2005 | Corrosion Science2005，，10： | 2 |
| 5 | Wnt signaling as a therapeutic target for bone diseases显示文摘 | HOEPPNER L H SECRETO F J WESTENDORF J J | 2009 | Expert Opin Ther Targets2009，13，4： | 1 |
| 6 | Wnt signaling as a therapeutic target for bone diseases显示文摘 | Hoeppner LH Secreto FJ Westendorf JJ | | 0，，4： | 1 |
| 7 | Wnt signaling during fracture repair显示文摘 | Frank J. Secreto Luke H. Hoeppner Jennifer J. Westendorf | 2009 | Current Osteoporosis Reports2009，，2： | 1 |
| 8 | Wnt signaling as a therapeutic target for bone diseases显示文摘 | Hoeppner L H Secreto F J Westendorf J J | 2009 | Expert Opin Ther Targets2009，13，4： | 1 |
| 9 | Fretting in orthopaedic: A review显示文摘 | HOEPPNER D W CHANDRASEKARAN V | 1994 | Wear1994，173，12： | 1 |
| 10 | Wnt signaling as a therapeutic target for bone diseases显示文摘 | Hoeppner LH Secreto FJ Westendorf JJ | 2009 | Expert Opin Ther Targets2009，13，4： | 1 |
| 11 | Multimodal treatment oflocally advanced esophageal adenocarcinoma : which regimenshould we choose? Outcome analysis of perioperative chemothera-py versus neoadjuvant chemoradiation in 105 patients显示文摘 | Hoeppner J Zirlik K Brunner T | 2014 | J SurgOncol2014，109，3： | 1 |
| 12 | A fretting fatigue normal pressure threshold concept显示文摘 | ADIBNAZARI S HOEPPNER D W | 1993 | Wear1993，160，12： | 1 |
| 13 | Wnt signaling as a therapeutic target for bone diseases 显示文摘 | Hoeppner LH Secreto FJ Westendorf JJ | 2009 | Expert Opin Ther Targets2009，13，4： | 1 |
| 14 | Maternal control of embryogenesis by MEDEA,a polycomb group gene in Arabidopsis显示文摘 | GROSSNIKLAUS U VIELLE-CALZADA J P HOEPPNER M A | 1998 | Science1998，280，： | 1 |
| 15 | Collagen 11a1 is indirec-tly activated by lymphocyte enhancer-binding factor 1(Lef1)and neg-atively regulates osteoblast maturation显示文摘 | Kahler RA Yingst SM Hoeppner LH er al | 2008 | Matrix Biol2008，27，4： | 1 |
| 16 | Wnt signaling during fracture repair 显示文摘 | Secreto FJ Hoeppner LH Westendorf JJ | 2009 | Curr Osteopoms Rep2009，7，2： | 1 |
| 17 | Comments on 'initiation and propagation of fretting fatigue cracks' 显示文摘 | HOEPPNER D W | 1977 | Wear1977，43，2： | 1 |
| 18 | Environmental effects in fretting fatigue 显示文摘 | HOEPPNER D W | 1981 | Fretting Fatigue1981，，： | 1 |
| 19 | Interactions between Sulfa Drug Sulfadiazine and Hydrophobic Talc Surfaces 显示文摘 | LU Guocheng LI Zhaohui Hoeppner N | 2014 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2014，446，5： | 1 |
| 20 | Fretting fatigue behavior in 7075-T6 aluminum alloy 显示文摘 | SACHIN R Shinde DAVID W Hoeppner | 2006 | Wear2006，，： | 1 |
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