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20篇 您的检索式：作者名="Hoehler F"

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	题名	作者	年代	出处	被引量
1	Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal.	Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler	2009	World Journal of Gastroenterology2009，15，4：	10
2	Simple phenomenological model for reinforcing steel under arbitrary load 显示文摘	Hoehler M S Stanton J F	2006	Journal of Structural Engineering2006，132，7：	1
3	Reduction ofpostsurgieal adhesions with intergel adhesion preventionsolution : a multieenter study of safety and efficacy afterconservation gynecologic surgery 显示文摘	Johns DB Keyport GM Hoehler F	2001	Fertil Steril2001，76，3：	1
4	Re-duction of postsurgieal adhesions with in-tergel adhesion prevention solution:a multi-eenter study of safety and efficacy after con-servative gynecologic surgery显示文摘	Johns DB Keyport GM Hoehler F	2001	Fertil Steril2001，76，3：	1
5	Dietary tryptophan need of broiler males from forty two to fifty-six days of age 显示文摘	Corzo A Moran J E F Hoehler D	2005	Poult Sci2005，84，：	1
6	Reduction of postsurgieal adhesions with intergel adhesion prevention solution:a muhieenter study of safety and efficacy after conservative gynecologic surgery显示文摘	Johns DB Keyport GM Hoehler F	2001	Ferti! Steril2001，76，3：	1
7	Reduction of postsurgical adhesions with Intergel adhesion prevention solution: a multieenter study of safety and efficacy after conservative gynecologic surgery 显示文摘	Johns D B Keyport G M Hoehler F	2001	Fertil Steril2001，76，3：	1
8	Bias and prevalence effects on kappa viewed in terms of sensitivity and specificity显示文摘	Hoehler F K	2000	Journal of clinical epidemiology2000，53，：	1
9	The effect of stress on colon motor and electrical activity in irritable bowel syndrome显示文摘	Welgan P Meshkinpour H Hoehler F	1985	Psychosom Med1985，47，：	1
10	Reduction of postsurgiealadhesions with Intergel adhesion prevention solution : amultieenterstudy of safety and efficacy after conservative gynecologic surgery显示文摘	Johns DB Keyport GM Hoehler F	2001	Fertil Steril2001，76，3：	1
11	Reduc'tion of postsurgiealadhesions with Intergel adhesion prevention solution : Amultieenterstudy of safety and efficacy after conservative gynecologic: surgery 显示文摘	Johns DB Keyport GM Hoehler F	2001	Fartil Staril2001，76，3：	1
12	Reduction of postsurgiealadhesions with intergel adhesion prevention solution: a multieenterstudy of safety and efficacy after conservative gynecologic surgery显示文摘	Johns DB Keyport GM Hoehler F	2001	Fertil Steril2001，76，3：	1
13	Relative effectiveness of methionine hydroxy analog compared to DL-methionine in broiler chickens显示文摘	Lemme A Hoehler D Brennan J J Mannion P F	2002	Poult Sci2002，81，：	1
14	Reduction of postsurgieal adhesions with Intergel adhesion prevention solution:a muhieenter study of safety and efficacy after conservative gynecologic surgery显示文摘	Johns DB Keyport GM Hoehler F	2001	Fertil Steril2001，，：	1
15	Simple phenomenological model for reinforcing steel under arbitrary load 显示文摘	Hoehler M S Stanton J F	2006	Journal of Structural Engineering2006，132，7：	1
16	Colonic dysfunction in patients with thoracic spinal cord injury 显示文摘	Glick M Meshkinpour H Hoehler F	1984	Gastroenterology1984，86，2：	1
17	Simple phenomenological model for reinforcing steel under arbitrary load 显示文摘	Hoehler M S Stanton J F	2006	Journal of Structural Engineering2006，132，7：	1
18	Reduction of postsurgieal adhesions with Intergel adhesion prevention solution:amultieenter study of safety and efficacy after conservative gynecologic urgery显示文摘	Johns DB Keyport GM Hoehler F	2001	Fertil Steril2001，76，3：	1
19	Reduction of postsurgieal ad- hesions with Intergel adhesion prevention solution:amultieenter study of safety and efficacy after conservative gynecologic surgery显示文摘	Johns D B Keyport G M Hoehler F	2001	Ferti\| Ster- il2001，76，3：	1
20	Dietary tryptophan need of broiler males from forty two to fifty-six days of age 显示文摘	CORZO A MORAN E F Jr HOEHLER D	2005	Poultry Science2005，84，：	1

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