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| 1 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 2 | Current strategies in systemic treatment of gastric cancer and cancer of the gastroesophageal junction显示文摘 | Markus Menges Thomas Hoehler | 2009 | Journal of Cancer Research and Clinical Oncology2009，，1： | 2 |
| 3 | Relative effectiveness of Methionine hydroxy analogue compared to DL- methionine in broiler chickens显示文摘 | Lemme A D Hoehler D Brennan J J | 2002 | Poultry Sci2002，81，： | 1 |
| 4 | Relative Effectiveness of Methionine Hydroxy Analog Compared to DL-Methionine in Broiler Chickens显示文摘 | Lemme A Hoehler D Brennan J J | 2002 | Poultry Science2002，81，： | 1 |
| 5 | Safety and efficacy of CPT-11/CF/5-Fu(IFL) versus FLF in previously untreaeed advanced or metastatic adoenocarcinoma of the stomach or gastroesophageal junction显示文摘 | Moehler MH Siebler J Hoehler T | 2003 | Proc AmSoc Clin Oncol2003，22，5： | 1 |
| 6 | Simple phenomenological model for reinforcing steel under arbitrary load 显示文摘 | Hoehler M S Stanton J F | 2006 | Journal of Structural Engineering2006，132，7： | 1 |
| 7 | Reduction ofpostsurgieal adhesions with intergel adhesion preventionsolution : a multieenter study of safety and efficacy afterconservation gynecologic surgery 显示文摘 | Johns DB Keyport GM Hoehler F | 2001 | Fertil Steril2001，76，3： | 1 |
| 8 | Re-duction of postsurgieal adhesions with in-tergel adhesion prevention solution:a multi-eenter study of safety and efficacy after con-servative gynecologic surgery显示文摘 | Johns DB Keyport GM Hoehler F | 2001 | Fertil Steril2001，76，3： | 1 |
| 9 | Martens, Field and laboratory studies of methane oxidation in an anoxic marine sediment, evidence for a methanogensulfate reducer consortium显示文摘 | HOEHLER T M ALPERIN M J ALBERT D B | 1994 | Global Biogeochem Cycles1994，8，： | 1 |
| 10 | The ongoing mystery of sea-floor methane 显示文摘 | Alperin M Hoehler T | 2010 | Science2010，329，5989： | 1 |
| 11 | Capecitabine plus oxaliplatin (CapOx) versus capecitabine plus gemcitabine (CapGem) versus gemcitabine plus oxaliplatin (GemOx): final results of a multicenter randomized phase Ⅱ trial in advanced pancreatic cancer 显示文摘 | Boeck S Hoehler T Seipelt G | 2008 | Ann Oncol2008，19，2： | 1 |
| 12 | Relative effectiveness of methionine hydroxy analogue compared to DL-methionine in broiler chickens显示文摘 | Lemme A D Hoehler D Brennan J J | 2002 | Poultry Sci2002，81，： | 1 |
| 13 | Field and laboratory studies of methane oxidation in an anoxic marine sediment-evidence for a methanogen-sulfate-reducer consortium显示文摘 | Hoehler T M Alperin M J Albert D B | 1994 | Global Biogeochem Cycles1994，8，： | 1 |
| 14 | Breast augmentation:the axillary approach显示文摘 | Hoehler H | 1973 | Br J Plast Surg1973，26，4： | 1 |
| 15 | Factors affecting the variability in ileal amino acid digestibility in corn distillers dried grains with solubles fed to growing pigs显示文摘 | Pahm A A Pedersen C Hoehler D | 2008 | Journal of animal science2008，86，9： | 1 |
| 16 | Rehtive effectiveness of methionine hydroxy analog compared to DL-methioinne in broiler chickens 显示文摘 | Lemme A Hoehler D Brennan J J | 2002 | Poultry Science2002，81，： | 1 |
| 17 | Dietary tryptophan need of broiler males from forty two to fifty-six days of age 显示文摘 | Corzo A Moran J E F Hoehler D | 2005 | Poult Sci2005，84，： | 1 |
| 18 | Reduction of postsurgieal adhesions with intergel adhesion prevention solution:a muhieenter study of safety and efficacy after conservative gynecologic surgery显示文摘 | Johns DB Keyport GM Hoehler F | 2001 | Ferti! Steril2001，76，3： | 1 |
| 19 | Thermodynamic control on hydrogen concentrations in anoxic sediments 显示文摘 | Hoehler TM Alperin MJ Albert DB Martens CS | 1998 | Geochim Cosmochim Acta1998，62，10： | 1 |
| 20 | Reduction of postsurgical adhesions with Intergel adhesion prevention solution: a multieenter study of safety and efficacy after conservative gynecologic surgery 显示文摘 | Johns D B Keyport G M Hoehler F | 2001 | Fertil Steril2001，76，3： | 1 |
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