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	题名	作者	年代	出处	被引量
1	4-羟基壬烯醛在糖尿病大鼠白内障中的代谢及发病中的作用显示文摘目的研究脂质过氧化代谢产物4-羟基壬烯醛(HNE)在糖尿病性白内障中的代谢过程以及发病中的作用。方法实验研究。采用两因素析因设计:处理因素为两水平(正常对照组和糖尿病组),时间因素为三水平(30、45、70d)。对于不同时期的正常与糖尿病大鼠晶状体采用下列方法进行处理:(1)使用一定量的带有放射活性的HNE与这些晶状体一起培养,测定HNE在品状体的代谢;(2)分光光度计法测定醛脱氢酶(ALDH)活性;(3)免疫印迹法检测ALDH和HNE-蛋白质加合物的表达。采用两因素析因设计定量资料方差分析对资料进行统计学处理。结果HNE在正常对照组的晶状体的代谢主要是与谷胱甘肽(GSH)结合形成GS-HNE(约45%),其次为经ALDH氧化成HNA(约9.1%);但糖尿病组晶状体的HNE与GSH结合径路受到抑制,GS—HNE形成减少,与正常组相比30d时减少约64%(F=49.59,P〈0.001);而糖尿病组晶状体的ALDH氧化径路代偿增强,HNA形成增多,70d比30d增多约1.7倍(F=11.51,P=0.0442)。糖尿病组的晶状体ALDH活性增高,免疫印迹法显示ALDH较正常对照组增多,HNE-蛋白质加合物较对照组减少。结论糖尿病性白内障中HNE与GSH的结合径路受到抑制,而氧化径路代偿性增强,揭示了结合径路的损伤可能与白内障发生有密切关系,氧化径路的代偿增强可能对防止糖尿病性白内障的发生有一定的意义。	肖天林 Mohammad hoeb Naseem .Ansari	2009	中华眼科杂志2009，45，3：	4
2	How we detect microbes and respond to them:the Toll-like receptors and their transducers 显示文摘	Beutler B Hoebe K Du X	2003	J Leukoc Bio12003，74，4：	1
3	The Unc93bl mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors3, 7 and 9 显示文摘	Tabeta K Hoebe K Janssen EM	2006	Nat Immunol2006，7，2：	1
4	High non-responsiveness of males and the elderly to standard hepatitis B vaccination among a large cohort of healthy employees显示文摘	Angelique P.A. Vermeiren Christian J.P.A. Hoebe Nicole H.T.M. Dukers-Muijrers	2013	Journal of Clinical Virology2013，，：	1
5	Identification of Lps2 as a key transducer of MyD88-independent T1R signalling显示文摘	HOEBE K DU X Georgel P	2003	Nature2003，424，6950：	1
6	Identification of Lps2 as a key transducer of MyD88-independent TIR signalling 显示文摘	Hoebe K Du X Georgel P	2003	Nature2003，424，6950：	1
7	Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotox/city to colorectal cancer cells 显示文摘	Temmink OH Hoebe EK van der BK	2007	Br J Cancer2007，96，：	1
8	Identification of LPS2 as a key transducer o f MyD88independent TIR signaling显示文摘	Hoebe K Du X Georgel P	2003	Nature2003，424，：	1
9	Mechanism of trifluorothymidine potentiation of oxaliplatin-induced cytotoxicity to colorectal cancer cells显示文摘	Temmink OH Hoebe EK Van der Born K	2007	Br J Cancer2007，96，2：	1
10	Luminescent materials and devices: lanthanide azatriphenylene complexes and electroluminescent charge transfer systems显示文摘	Bakker B H Goes M Hoebe N	2000	Coord Chem Rev2000，208，：	1
11	Norovirus outbreak among primary school children who had played in a rec- reational water fountain显示文摘	Hoebe C Vennema H De Roda - Husman A M	2004	J Infect Dis2004，189，4：	1
12	Association of histoblood group antigens and susceptibility to norovirus infections显示文摘	Rockx BH Vennema H Hoebe CJ	2005	J Infect Dis2005，191，5：	1
13	Identification of Lps2 as a key transducer of MyD88-independent TIR signalling 显示文摘	Hoebe K Du X Georgel P	2003	Na- ture2003，424，：	1
14	TLR signaling pathways: opportunities for activation and blockade in pursuit of therapy 显示文摘	Hoebe K Jiang Z Georgel P	2006	Curr Pharm Des2006，12，32：	1
15	Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways 显示文摘	Hoebe K Janssen EM Kim SO Alexopoulou L Flavell RA Han J Beutler B	2003	Nat Immunol2003，4，12：	1
16	Association of bisto-blood group antigens and susceptibility to norovirus infections 显示文摘	Rockx BH Vennema H Hoebe CJ	2005	J Infect Dis2005，191，5：	1
17	Differential effects of Pentoxfylline on the hepatic inflammatory response in porcine liver cell cultures increase in inducible nitric oxide synthase expression显示文摘	Hoebe K H Gonza1ez R αmon N Nijmeijer S M	2001	Biochem pharmacol2001，61，9：	1
18	Identification of Lps2 as a key transducer of MyD88-independentTIR signaling显示文摘	Hoebe K Du X Georgel P	2003	Nature2003，424，6950：	1
19	Regulation of T-cell function by endogenously produced angiotensin Ⅱ 显示文摘	Hoeb NE Guzik TJ Chen W	2009	Am J Physiol Regul Integr Comp Physio12009，296，2：	1
20	How we detect microbes and respond to them:the Toll-like receptors and their transducers显示文摘	Beutler B Hoebe K Du X	2003	J Leukoc Biol2003，74，4：	1

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