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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | Molecular studies into therole of CD 44 variants in metastasis in gastric cancer显示文摘 | Hsieh HF Yu JC Ho LI | 1999 | Mol-Pathol1999，52，1： | 1 |
| 3 | Diffraction resonance with strong optical - field enhancement from gain - assisted hybrid plasmonic structure显示文摘 | Zhang HX Lu HF Ho HP | 2010 | Appl Phys Lett2010，100，16： | 1 |
| 4 | Distribution of Th1 and Th2 cell populations in human peripheral and decidual T cells from normal and an embryonic pregnancies显示文摘 | Ho HN Chao KH Chen HF | 2001 | Fertil Steril2001，76，4： | 1 |
| 5 | Pregnancy achieved by intracytoplasmic sperm injection using cryopreserved semen from a man with testicular cancer显示文摘 | Ho HN Chen HF | 1996 | Hum Reprod1996，11，12： | 1 |
| 6 | ROS Mediates Baicalin-induced Apoptosis in Human Promyelocytic Leukemia HL-60 Cells through the Expression of the Gadd153 and Mitochondrial-dependent Pathway 显示文摘 | Lu HF hsueh SC Hsueh YC Ho YT | 2007 | Anticancer Research2007，27，1： | 1 |
| 7 | Clinical and pathological characteristics of secondary thyroid cancer显示文摘 | Lin JD Weng HF Ho YS | 1998 | Thyroid1998，8，2： | 1 |
| 8 | Mitochondrial uncoupling protein-2(UCP2)mediates leptin protection against MPPC toxicity in neuronal cells显示文摘 | Ho PW Liu HF Ho JW | 2010 | Neurotox Res2010，17，4： | 1 |
| 9 | Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage显示文摘 | Harn HJ Hsieh HF Ho LJ | 1998 | Histopathology1998，33，2： | 1 |
| 10 | Statin use and the risk of female lung cancer:, a population-based case-control study 显示文摘 | Cheng MH Chiu HF Ho SC | 2012 | Lung Cancer2012，75，3： | 1 |
| 11 | Clincal and pathological characteristics of secondary thyroid cancer 显示文摘 | Lin JD Weng HF Ho YS | 1998 | Thyroid1998，8，2： | 1 |
| 12 | Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase,COMT) expression in an ELISA-based system 显示文摘 | Ho PW Tse ZH Liu HF | 2013 | ?LoS One2013，8，74： | 1 |
| 13 | Molecular studies into the role of CD44 variant in metastasis in gastric cancer 显示文摘 | Hsieh HF Yu JC Ho LI | 1999 | J Clin Pathol: Mol Pathol1999，52，： | 1 |
| 14 | Chiu molecular studies into the role of CD44 variants in metastasis in gastric cancer显示文摘 | Hsieh Hf Yu JC Ho LI | 1999 | Mol-Pathol1999，52，1： | 1 |
| 15 | Clinical and pathological characteristics of secondary thyroid cancer显示文摘 | Lin JD Weng HF Ho YS | 1998 | Thyroid1998，8，2： | 1 |
| 16 | Lung cancer mortality reduction after installation of tap-water supply system in an arseniasis-endemic area in Southwestern Taiwan 显示文摘 | Chiu HF Ho SC Yang CY | 2004 | Lung Cancer2004，46，： | 1 |
| 17 | Assessment of cellular estrogenic activity based on estrogen receptor-mediated reduction of soluble-form catechol-O-methyltransferase(COMT)expression in an ELISA-based system显示文摘 | Ho PWjTse ZH Liu HF | 2013 | PLoS One2013，8，74： | 1 |
| 18 | Clinical and pathological characteristics of secondary thyroid cancer显示文摘 | Lin JD Weng HF Ho YS | 1998 | Thyroid1998，8，2： | 1 |
| 19 | Apoptosis in nasopharyngeal carcinoma as related to histopathological characteristics and clinical stage显示文摘 | Harn HJ Hsieh HF Ho LI | 1998 | Histopathology1998，33，2： | 1 |
| 20 | The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: a crosscheck hypothesis显示文摘 | Tsai MK Ho HN Chien HF | 2004 | Transplantation2004，77，1： | 1 |
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