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| 1 | Chinese Atherosclerosis Risk Evaluation(CARE II)study:a novel cross-sectional,multicentre study of the prevalence of high-risk atherosclerotic carotid plaque in Chinese patients with ischaemic cerebrovascular events-design and rationale显示文摘Background:Carotid atherosclerotic plaque is identified as one of the main sources of ischaemic stroke.However,the prevalence of carotid high-risk atherosclerotic plaque in Chinese patients with ischaemic cerebrovascular events has been inconsistently reported and needs to be investigated in a large population.Objectives:The primary objective of CARE II study was to determine the prevalence and characteristics of high-risk features of atherosclerotic plaques in the carotid arteries in Chinese patients with recent ischaemic stroke or transient ischaemia attack(TIA).The relationship between carotid plaque features and cerebral infarcts,the differences of carotid plaque patterns among different regions of China and the gender specific characteristics of carotid plaque will be also determined.Study design:The CARE II study will enrol 1000 patients with recent ischaemic stroke or TIA and carotid plaque from 13 hospitals and medical centres across China.In this cross-sectional,non-randomised,observational,multicentre study,all patients will undergo carotid artery MRI of bilateral carotid arteries and routine brain MRI with standardised protocols.The MRI will be interpreted at core reading centres to evaluate the characteristics of morphology and compositions of carotid plaque.Conclusions:This is a cross-sectional,multicentre study to investigate the prevalence and characteristics of high-risk atherosclerotic carotid plaque in Chinese patients with stroke and TIA by using high-resolution MRI of vessel wall.This trial is sufficiently powered to demonstrate the prevalence of carotid high-risk plaque and to explore regional differences in Chinese patients who suffered stroke. | Xihai Zhao Rui Li Daniel S Hippe Thomas S Hatsukami Chun Yuan CARE-II Investigators | 2017 | Stroke & Vascular Neurology2017，2，1： | 21 |
| 2 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 3 | New clinical aspects of whole body hyperthermia显示文摘 | Eisler K Hipp R Gogler S | 1990 | Adv Exp Med Biol1990，267，： | 1 |
| 4 | A lower solubility recommends the use of desflurane more than isoflurane,halothane and enflurane under low flow condition显示文摘 | Hargasser S Hipp R Breinbener B | 1995 | J Clin Anesth1995，7，： | 1 |
| 5 | Proton magnetic resonance spectroscopy predicts survival in children with diffuse intrinsic pontine glioma 显示文摘 | Steffen-Smith EA Shih JH Hipp S J et O1 | 2011 | J Neurooncol2011，105，2： | 1 |
| 6 | Low back pain: prediction of short term outcome of facet joint injection with bone scintigraphy 显示文摘 | Pneumaticos S G Chatziioannou S N Hipp J A | 2006 | Radiology2006，238，2： | 1 |
| 7 | Mammalian target of rapamycin inhibition induces cell cycle arrest in diffuse large B cell lymphoma(DLBCL)cells and sensitises DLBCL cells to rituximab显示文摘 | WANNERK HIPP S OELSNERM | 2006 | Br J Haematol2006，134，5： | 1 |
| 8 | Novel indirubin derivatives,promising anti-tumor agents inhibiting cyclin-dependent kinases显示文摘 | Merz K H Schwahn S Hippe F et a1 | 2004 | International Journal of Clinical Pharmacology and Therapeutics2004，42，11： | 1 |
| 9 | Novel indirubin derivatives, promising anti-tumor agents inhibiting cyclin dependent kinases显示文摘 | Merzk H Schwahn S Hippe F | 2004 | International Journal of Clinical Pharmacology and Therapeutics2004，4201，： | 1 |
| 10 | Glycerol conversion to 1,3-propanediol by newly isolated Clostridia显示文摘 | Biebl H Marten S Hippe H | 1992 | Applied Microbiology and Biotechnology1992，36，： | 1 |
| 11 | Comparison of carotid atherosclerotic plaques between subjects in Northern and Southern China: a Chinese atherosclerosis risk evaluation study显示文摘Background and purpose To investigate differences in the characteristics of carotid atherosclerotic plaques of symptomatic subjects in northern and southern China using MRI.Methods Sixty-three subjects in northern China(mean age:59.1±8.6 years,45 men)and 56 subjects in southern China(mean age:60.4±8.6 years,38 men)were included.All subjects underwent carotid artery multicontrast vessel wall MRI.Plaque morphology,calcification,lipid-rich necrotic core,intraplaque haemorrhage,luminal surface disruption and high-risk plaque were measured and identified.All plaque characteristics were compared between subjects in northern and southern China using Mann-Whitney U test or χ^(2) test.results Compared with subjects in southern China,those in northern China had significantly greater areas for lumen(57.7±14.9 mm^(2) vs 50.4±18.3 mm^(2),p=0.009),wall(38.4±13.1 mm^(2) vs 31.9±11.7 mm^(2),p<0.001)and total vessel(96.1±20.2 mm^(2) vs 82.4±22.7 mm^(2),p=0.001)and mean wall thickness(1.25±0.43 mm vs 1.13±0.40 mm,p=0.019).χ^(2) analysis showed that subjects in northern China tended to have a higher prevalence of intraplaque haemorrhage(14.3%vs 5.4%,p=0.106)and high-risk plaque(20.6%vs 10.7%,p=0.140)than those in southern China,although these differences were not statistically significant(all p>0.05).Conclusion Subjects in northern China have significantly larger vessel size and may have a higher prevalence of vulnerable plaques than those in southern China.Our findings provide additional perspective to optimise the management of cerebrovascular disease in individuals in different regions in China. | Dandan Yang Yang Ji Dan Wang Hiroko Watase Daniel S Hippe Xihai Zhao Chun Yuan | 2020 | Stroke & Vascular Neurology2020，5，2： | 1 |
| 12 | Determination of the antioxidative potential of human plasma after supplementation with pycnogenol and whey显示文摘 | Janisch K Hippeli S Dornisch K | 2002 | Food Res Int2002，35，： | 1 |
| 13 | Glycerol conversion to 1,3-propanediol by newly isolated clostridia显示文摘 | Biebl H Marten S Hippe H | 1992 | Appl MicrobiolBiotechnol1992，36，5： | 1 |
| 14 | Synthesis and self-assembly of a functional monoclonal antibody in transgenic Nicotiana tabacum显示文摘 | During K Hippe S Kreuzaler F | 1990 | Plant Molecular Biology1990，15，： | 1 |
| 15 | Glycerol conversion to 1,3-propanediol by newly isolated Clostridia显示文摘 | Biebl H Marten S Hippe H | 1992 | Applied Microbiology and Biotechnology1992，36，： | 1 |
| 16 | Efficient and Accurate Calculation of Ray Theory Seismic Travel Time through Variable Resolution 3D Earth Models显示文摘 | Ballard S Hipp J.R Young C.J | | 0，，60： | 1 |
| 17 | Efficient and accurate cal- culation of ray theory seismic travel time through vari- able resolution 3D earth models显示文摘 | Ballard S Hipp J R Young C J | 2009 | Seismological Re- search Letters2009，80，6： | 1 |
| 18 | Novel indirubin derivatives, promising anti-tumor agents inhibiting cyclin dependent kinases 显示文摘 | MERZ KH SCHWAHN S HIPPE F | 2004 | International Journal of Clinical Pharmacology and Therapeutics2004，42，11： | 1 |
| 19 | Glycerol conversion to 1,3-propanediol by newly isolated Clostridia显示文摘 | Biebl H Marten S Hippe H | 1992 | Appl Mi crobial Biotechnol1992，36，5： | 1 |
| 20 | Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3,cyclin E,cyclin A,and surviving显示文摘 | Decker T Hipp S Ringshausen I | 2003 | Blood2003，101，1： | 1 |
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