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| 1 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 2 | The mode of vasoinhibitory action of a pyridazinone derivative (MCI-154),a new cardiotonic agent,on contractile responses induced by alpha-adrenoceptor agonists and ^45Ca influx in isolated vascular smooth muscles显示文摘 | Shibata S Satake N Hester RK Kurahashi K Ito M | 1988 | Eur J Pharmacol1988，145，2： | 1 |
| 3 | Gas hydrate measurements at Hydrate Ridge using Raman spectroscopy显示文摘 | HESTER K C DUNK R M WHITE S N | 2007 | Geochimica et Cosmochimica Acta2007，71，： | 1 |
| 4 | Preparationof pH-responsive polymer membranes by self-organiza-tion显示文摘 | Hester J F Olugebefola S C Mayes A M | 2002 | J Membr Sci2002，208，： | 1 |
| 5 | Enhanced cleavage rates following in vitro maturation of pig oocytes within polydimethylsiloxane-borosilicate microchannels 显示文摘 | Hester P N Roseman H M Clark S G | 2002 | Theriogenology2002，57，： | 1 |
| 6 | Oral administration of the cyclooxygenase-2 (COX-2) inhibitor meloxicam blocks ovulation in non-human primates when administered to simulate emergency contraception显示文摘 | Hester K Harper M Duffy D | 2010 | Hum Reprod2010，25，2： | 1 |
| 7 | Girls' and boys' experiences and perceptions of parental discipline and punishment while growing up in China and England显示文摘 | Hester M He JP Tian L | | 0，，： | 1 |
| 8 | Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococeus species 显示文摘 | VILGALYS R HESTER M | 1990 | Journal of Bacteriolgy1990，172，： | 1 |
| 9 | Neural correlates of attentional bias in addiction显示文摘 | Hester R Luijten M | 2014 | CNS Spectr2014，19，： | 1 |
| 10 | Refinement of the fundamental niche of black mangrove (Avicennia germinans) seedlings in Louisiana: Applications for restoration显示文摘 | ALLEMAN L K HESTER M W | 2011 | Wetlands Ecology Manage2011，19，： | 1 |
| 11 | Discovery and initial development of a novel class of antibacterials:inhibitors of Staphylococcus aureus transcription/translation显示文摘 | Larsen S D Hester M R Craig Ruble J | | 0，，24： | 1 |
| 12 | Continuous ion-exclusion chromatography system for acid/sugar separation显示文摘 | Springfield R M Hester R D | 1999 | Separation Science and Technology1999，34，67： | 1 |
| 13 | Preparation of protein - resistant surfaces on poly( vinylidene fluoride) membranes via surface segregation显示文摘 | Hester J F Banerjee P Mayes A M | 1999 | Macromolecules1999，32，： | 1 |
| 14 | Bone densitometry as indicator of percentage tibia ash in broiler chicks fed varying dietary calcium and phosphorus levels 显示文摘 | ONYANGO E M HESTER P Y STROSHINE R | 2003 | Poultry Science2003，82，： | 1 |
| 15 | Clinical,demographic,and situational factors linked to distress associated with benign breast biopsy显示文摘 | Steffens R F Wright H R Hester M Y | 2011 | J Psychosoc Oncol2011，29，1： | 1 |
| 16 | Moving beyond the banks: hyporheic restoration is fundamental to restoring ecologicalservices and functions显示文摘 | Hester E R Gooseff M N | 2010 | Environmental Science and Technology2010，44，5： | 1 |
| 17 | Design and performance of foul-resistant poly( vinylidene fluoride) membranes prepared in a single-step by surface segregation 显示文摘 | Hester J F Mayes A M | 2002 | J Membr Sci2002，202，： | 1 |
| 18 | The diabetes subgroup baseline charac- teristics of the Avoiding Cardiovascular Events Through Combination Therapy in Patients Living With Systolic Hypertension (ACCOMPLISH) trial显示文摘 | Bakris G Hester A Weber M | 2008 | J Cardiometab Syndr2008，3，4： | 1 |
| 19 | Psycho- logical effects of dance-based group exergaming in obese adoles- cents显示文摘 | Wagener T Fedele D Mignogna M Hester C Gillaspy S | 2012 | Pediatric Obesity2012，，5： | 1 |
| 20 | Preparation of pH-responsive polymer membranes by self-organization 显示文摘 | Hester J F Olugebefola S C Mayes A M | 2002 | J Membr Sci2002，208，： | 1 |
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