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	题名	作者	年代	出处	被引量
1	A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals:A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis显示文摘The recent emergence and application of engineered endonucleases have led to the development of genome editing tools capable of rapidly implementing various targeted genome editions in a wide range of species.Moreover,these novel tools have become easier to use and have resulted in a great increase of applications.Whilst gene knockout(KO) or knockin(KI) animal models are relatively easy to achieve,there is a bottleneck in the detection and analysis of these mutations.Although several methods exist to detect these targeted mutations,we developed a heteroduplex mobility assay on an automated microfluidic capillary electrophoresis system named HMA-CE in order to accelerate the genotyping process.The HMA-CE method uses a simple PCR amplification of genomic DNA(gDNA) followed by an automated capillary electrophoresis step which reveals a heteroduplexes(HD) signature for each mutation.This allows efficient discrimination of wild-type and genome-edited animals down to the single base pair level.	Vanessa Chenouard Lucas Brusselle Jean-Marie Heslan Séverine Remy Séverine Ménoret Claire Usal Laure-Hélène Ouisse Tuan Huy NGuyen Ignacio Anegon Laurent Tesson	2016	Journal of Genetics and Genomics2016，43，5：	4
2	Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts 显示文摘	Louvet C Chiffoleau E Heslan M	2005	Am J Transplant2005，5，9：	1
3	Identification of a new member of the CD20/Fc epsilon RI beta family overexpressed in tolerated allografts 显示文摘	Louvet C Chiffoleau E Heslan M	2005	Am J Transplant2005，5，9：	1
4	Presentation of donor major histo- compatibility complex antigens by bone marrow dendritic cell-de- rived exosomes modulates allograft rejection 显示文摘	Peche H Heslan M Usal C	2003	Transplantation2003，76，10：	1
5	Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid 显示文摘	KMartin JC Brriou G Heslan M	2014	Mucosal Immuno12014，7，1：	1
6	Role of IFNgamma in allograft tolerance mediated by CD4+CD25+regulatory T cells by induction of IDO in endothelial cells显示文摘	Thebault P Condamine T Heslan M	2007	Am J Transplant2007，7，11：	1
7	TLR9 ligand enhances proliferation of rat CD4+ T cell and modulates suppressive activity mediated by CD4 + CD25 + T cell显示文摘	Chiffoleau E Heslan JM Heslan M		0，，：	1
8	Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion显示文摘	Josien R Heslan M Brouard S	1998	Blood1998，92，12：	1
9	Presentation of donor major histocompatibility complex antigens by bone marrow dendritic-cell-derived exosomes modulates allograft rejection显示文摘	Peche H Heslan M Usal C	2003	Transplantation2003，76，：	1
10	Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell derived exosomes modulates allograft rejection显示文摘	Heslan M Usal C	2003	Transplantation2003，76，10：	1
11	Importance, mechanisms and limitations of the distant bystander effect in cancer gene therapy of experimental liver tumors显示文摘	Heslan JM Fabre M	2002	Cancer Lett2002，179，1：	1
12	TLR9 ligand enhances proliferation of rat CD4+ T cell and modulates suppressive activity mediated by CD4^+CD25^+T cell 显示文摘	Chiffoleau E Heslan JM Heslan M	2007	Int Immunel2007，19，2：	1
13	Rapid and accurate determination of zygosity in transgenic animals by real-time quantitative PCR显示文摘	Tesson L Heslan J M Menoret S	2002	Transgenic Res2002，11，1：	1
14	Importance,mechanisms and limitations of the distant bystander effect in cancer gene therapy of experimental liver tumors显示文摘	Carsten Engelmann Jean Marie Heslan	2002	Cancer Letters2002，179，：	1
15	Critical requirement for graft passenger leukocytes in allograft tolerance induced by donor blood transfusion显示文摘	Josien R Heslan M Brouard S	1998	Blood1998，92，12：	1
16	Importance,mechanisms and limitations of the distant bystander effect in cancer gene therapy of experimental liver tumors显示文摘	Carsten Engelmann Jean Marie Heslan	2002	Cancer Letters2002，179，：	1
17	Importance,mechanisms and limitations of the distant bystander effect in cancer gene therapy of experimental liver tumors显示文摘	Engelmann C Heslan JM Fabre M	2002	Cancer Lett2002，179，1：	1
18	Importance, mechanisms and limitations of the distant bystander effect in cancer gene therapy of experimental liver tumors显示文摘	Carsten Engelmann Jean Marie Heslan	2002	Cancer Letters2002，179，：	1
19	Importance, mechanisms and limitations of the distant bystander effect in cancer gene therapy of experimental liver tumors 显示文摘	Engelmann C Heslan JM Fabre M	2002	Cancer Lett2002，179，1：	1
20	New evidence for a role of allograft accommodation in long-term tolerance显示文摘	Heslan JM Renaudin K Thebault P	2006	Transplantation2006，，09：	1

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