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| 1 | Triterpenoid of avocado (Persea americana) seed and its cytotoxic activity toward breast MCF-7 and liver HepG2 cancer cells显示文摘Objective:To determine the structure of triterpenoid isolated from avocado seeds and the cytotoxic effect on MCF-7 and Hep G2 cells.Methods:The powder sample was macerated with ethanol,followed with separation of the extract by column chromatography.The target compound was monitored on thin layer chromatography plate and reagent Lieberman–Buchard.The isolated compound was characterized by spectral analysis,mainly ultraviolet,infrared,and liquid chromatographymass spectroscopy and their spectroscopic data with those reported in literature were compared.In vitro cytotoxic activity was investigated against Vero,MCF-7,and Hep G2 cell lines using MTT assay.Results:A triterpenoid compound was isolated from ethanol extract.The extracts,fraction(F3),and the isolated compound showed a significant cytotoxic activity against all investigated cell lines.MTT assay showed that the triterpenoid isolate inhibited cell proliferation of MCF-7 and Hep G2 cell line with the IC50 values of 62 mg/m L and 12 mg/m L,respectively,and was safe to normal cells.Conclusions:The results of the present study reveal that triterpenoid from avocado seeds have the potential for further development as anticancer agents. | Andi Nur Fitriani Abubakar Suminar Setiati Achmadi Irma Herawati Suparto | 2017 | Asian Pacific Journal of Tropical Biomedicine2017，7，5： | 3 |
| 2 | Relationship of visual impairment and peripheral artery disease with the occurrence of diabetic foot ulcers in Dr. Moewardi Hospital显示文摘Objective: One of the diabetes mellitus (DM) complications is foot ulcers. Foot ulcers are influenced by many factors. DM puts patients at risk of injury because of visual impairment. Hyperglycemia can damage blood vessels, which results in peripheral artery disease (PAD). The purpose of this study was to find the relationship of visual impairment and PAD with diabetic foot ulcers. Methods: This research used observational analytic study with case–control methods. It used purposive sampling in 34 DM patients with foot ulcers and 34 DM patients without foot ulcers. The research instruments were an interview guide to assess visual impairment, physical examination to assess PAD, and documentation study, which was used to know the incidence of diabetic ulcers. Results: The results showed that the respondents who experienced ulcers with visual impairment were 44.1% and the respondents who had foot ulcers with PAD were 73.5%. The results of statistical tests showed that there was no relationship between visual impairment and the incidence of ulcers (P = 0.166). The respondents with PAD will have a chance to suffer from foot ulcers 5.808 times higher than those who do not have PAD. Conclusions: There is no relationship between visual impairment and the incidence of diabetic foot ulcers in Dr. Moewardi Hospital, but there is relationship between PAD and the incidence of diabetic foot ulcers in Dr. Moewardi Hospital. Suggestions of this study are to do foot screening and educate about the importance of foot care to prevent the occurrence of diabetic ulcers. | Okti Sri Purwanti Krisna Yetti Tuti Herawati | 2019 | Frontiers of Nursing2019，6，2： | 2 |
| 3 | Prevalence of the mitochondrial DNA A1555G mutation in sensorineural deafness patients in island Southeast Asia显示文摘 | Safarina G. Malik Nova Pieter Herawati Sudoyo Abdul Kadir Sangkot Marzuki | 2003 | Journal of Human Genetics2003，，9： | 1 |
| 4 | The impact of steri-lized females on enclosed populations of ricefield rats显示文摘 | Jacob J Herawati N A Davis S A | | 0，，04： | 1 |
| 5 | Response of carrot on N,P, K fertilizerv显示文摘 | Bakrie Azlina Heryati Herawati Thalib | 1994 | A cta Horticulturae1994，，369： | 1 |
| 6 | Quality of life in early Parkinson’s disease treated with levodopa/carbidopa/entacapone显示文摘 | Fung VS Herawati L Wan Y | 2009 | Mov Disord2009，24，1： | 1 |
| 7 | Soil microbial communities and activities under intensive organic and conventional vegetable farming in West Java,Indonesia显示文摘 | Moeskops B Buchan D Sleutel S Herawaty L Husen E Saraswati R Setyorini D Neve S D | | 0，，： | 1 |
| 8 | Nuclear mitochondrial interplay in the modulation of the homopolymeric tract length heteroplasmy in the control (D-loop) region of the mitochondrial DNA显示文摘 | Safarina Malik Herawati Sudoyo Patcharin Pramoonjago Helena Suryadi Tika Sukarna Marleisje Njunting Edhyana Sahiratmadja Sangkot Marzuki | 2002 | Human Genetics2002，，5： | 1 |
| 9 | Cadmium, copper, and zinc levels in rice and soil of Japan, Indonesia, and China by soil type显示文摘 | Herawati N Suzuki S Hayashi K | 2000 | Bulletin of Environmental Contamination and Toxicology2000，64，1： | 1 |
| 10 | Cadmium,copper,and zinc levels in rice and soil of Japan,Indonesia,and China by soil type显示文摘 | HERAWATI N SUZUKI S HAUASJO K | | 0，，： | 1 |
| 11 | Effect of supple- mentation Sacharonyces cerevisiae and Leucaena leucocephala on low quality roughage feed in beef cattle diet 显示文摘 | Herawaty R Jamarun N Zain M | 2013 | Pakistan Journal of Nutrition2013，12，2： | 1 |
| 12 | Cadmium, Copper, and Zinc Levels in Rice and Soil of Japan, Indonesia, and China by Soil Type显示文摘 | Herawati N Suzuki S Hayashi K | 2000 | Bulletin of environmental contamination and toxicology2000，64，1： | 1 |
| 13 | Cricket Farming for Animal Protein as Profitable Business for Small Farmers in Indonesia显示文摘 | Asnath Maria Fuah Hotnida Caroline Herawati Siregar Yuni Cahya Endrawati | 2015 | Journal of Agricultural Science and Technology(A)2015，5，4： | 0 |
| 14 | Reproductive responses of rice field rats(Rattus argentiventer)following treatment with the contraceptive hormones,quinestrol and levonorgestrol显示文摘The ricefield rat,Rattus argentiventer,is a significant pest of rice in Southeast Asia.Fertility control methods have the potential to provide safe and effective alternatives to control methods that often include indiscriminate use of rodenticides or electric barriers.The aim of this laboratory study was to assess uptake of bait coated with different concentrations of the contraceptive hormones,quinestrol(E)and levonorgestrel(P),delivered alone and in combination(i.e.EP-1)and determine the short-term effects on reproductive parameters of adult male and female R.argentiventer.In Experiment 1,2 concentrations of E,P,and EP-1(10,20 ppm)were fed to groups of wild-caught rats for 7 days.In females,both E and EP-1 induced uterine edema.In males,EP-1 reduced epididymis and seminal vesicle weights and lowered sperm motility.However,these responses were inconsistent due to low bait acceptance,especially with increasing concentrations.In Experiment 2,EP-1(0,20,50,100 ppm)was administered by oral gavage daily for 7 days to male R.argentiventer.There were significant reductions in epididymal and seminal vesicle weights for all oral doses of EP-1,in sperm counts for the 50 ppm dose,and in sperm motility for the 20 and 50 ppm doses compared to the control group.To select the optimum dose of EP-1,we must address the poor acceptance of contraceptive-coated baits by ricefield rats.Further research is required to improve the palatability of EP-1 and to test its uptake underfield conditions. | Alexander M.STUART Nur‘Aini HERAWATI RISNELLI SUDARMAJI Ming LIU Zhibin ZHANG Hongjun LI Grant R.SINGLETON Lyn A.HINDS | 2022 | Integrative Zoology2022，17，6： | 0 |
| 15 | Hypomagnesemia is a risk factor for metabolic syndrome and type 2 diabetes mellitus in native Balinese显示文摘Objective:To determine the prevalence of hypomagnesemia and the risk of hypomagnesemia on metabolic syndrome and type 2 diabetes mellitus events in native Balinese.Methods:A cross-sectional population-based study was conducted in 111 subjects among native Balinese.Chi-square test was used to determine the prevalence risk(OR)of hypomagnesemia for metabolic syndrome and diabetes.Results:Prevalence of hypomagnesemia was 17.1%.The prevalence of hypomagnesemia was higher in subjects with metabolic syndrome and type 2 diabetes mellitus than those without(34.7%vs.12.5%,P=0.025;and 60.0%vs.15.1%,P=0.035).Hypomagnesemia was a risk factor for metabolic syndrome(OR=3.7;95%CI,1.28-10.83)and type 2 diabetes mellitus(OR=8.4;95%CI,1.30-54.50).Conclusion:The prevalence of hypomagnesemia is very high among native Balinese and hypomagnesemia is an important risk factor for metabolic syndrome and type 2 diabetes mellitus events in the population. | PANDE DWIPAYANA MADE RATNA SARASWATI WIRA GOTERA ANAKAGUNG GDE BUDHIARTA KETUT SUASTIKA SAFARINA MALIK HERAWATI SUDOYO NAEMI KAJIWARA HIROSHI TANIGUCHI | 2013 | Family Medicine and Community Health2013，1，1： | 0 |
| 16 | Effect of Substitution of Fermented Kapok Seed (Ceiba petandra) to Soybean Meal on Production and Egg Quality from Native Laying Hens显示文摘 | Erman Syahruddin Rita Herawaty Azhar Ibrahim | 2015 | Journal of Agricultural Science and Technology(A)2015，5，10： | 0 |
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