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| 1 | Report of Incidence and Mortality in China Cancer Registries,2008显示文摘Objective: Annual cancer incidence and mortality in 2008 were provided by National Central Cancer Registry in China, which data were collected from population‐based cancer registries in 2011. Methods: There were 56 registries submitted their data in 2008. After checking and evaluating the data quality, total 41 registries' data were accepted and pooled for analysis. Incidence and mortality rates by area (urban or rural areas) were assessed, as well as the age‐ and sex‐specific rates, age‐standardized rates, proportions and cumulative rate. Results: The coverage population of the 41 registries was 66,138,784 with 52,158,495 in urban areas and 13,980,289 in rural areas. There were 197,833 new cancer cases and 122,136 deaths in cancer with mortality to incidence ratio of 0.62. The morphological verified rate was 69.33%, and 2.23% of cases were identified by death certificate only. The crude cancer incidence rate in all areas was 299.12/100,000 (330.16/100,000 in male and 267.56/100,000 in female) and the age‐standardized incidence rates by Chinese standard population (ASIRC) and world standard population (ASIRW) were 148.75/100,000 and 194.99/100,000, respectively. The cumulative incidence rate (0-74 years old) was of 22.27%. The crude incidence rate in urban areas was higher than that in rural areas. However, after adjusted by age, the incidence rate in urban was lower than that in rural. The crude cancer mortality was 184.67/100,000 (228.14/100,000 in male and 140.48/100,000 in female), and the age‐standardized mortality rates by Chinese standard population (ASMRC) and by world population were 84.36/100,000 and 114.32/100,000, respectively. The cumulative mortality rate (0-74 years old) was of 12.89%. Age‐adjusted mortality rates in urban areas were lower than that in rural areas. The most common cancer sites were lung, stomach, colon‐rectum, liver, esophagus, pancreas, brain, lymphoma, breast and cervix which accounted for 75% of all cancer incidence. Lung cancer was the leading cause of cancer death, followed by gastric cancer, liver cancer, esophageal cancer, colorectal cancer and pancreas cancer, which accounted for 80% of all cancer deaths. The cancer spectrum varied by areas and sex in rural areas, cancers from digestive system were more common, such as esophageal cancer, gastric cancer and liver cancer, while incidence rates of lung cancer and colorectal cancer were much higher in urban areas. In addition, breast cancer was the most common cancer in urban women followed by liver cancer, gastric cancer and colorectal cancer. Conclusion: Lung cancer, gastric cancer, colorectal cancer, liver cancer, esophageal cancer and female breast cancer contributed to the increased incidence of cancer, which should be paid more attention to in further national cancer prevention and control program. Different cancer control strategies should be carried out due to the varied cancer spectrum in different groups. | Wan-qing C hen Rong-shou Zheng Si-wei Zhang Ni Li Ping Zhao Guang-lin Li Liang-you Wu Jie He | 2012 | Chinese Journal of Cancer Research2012，24，3： | 45 |
| 2 | Hepatocytic differentiation of mesenchymal stem cells in cocultures with fetal liver cells显示文摘瞄准:为了与胎儿的肝细胞(FLC ) 和可能性在合作文化调查间充质的干细胞(MSC ) 的 hepatocytic 区别膨胀,区分了 hepatocytic 房间。方法:MSC 被制动火箭与绿荧光灯的蛋白质(GFP ) 标记病毒的基因转导变异。同种细胞的显著 MSC 在用与干细胞补充的fibronectin涂的培养皿和媒介刺激条件的肝下面是也有教养的因素( SCF ), hepatocyte 生长因素( HGF ),表皮的生长因素( EGF ),和成纤维细胞生长因素 4 ( FGF-4 )独自一个,或在刚孤立的 FLC 的存在。在合作文化的房间被收获,并且 GFP+ 或 GFP- 房间用荧光被分开激活的房间排序。为肝 specific 标记 cytokeratin-18 (CK-18 ) 的反向的抄写聚合酶链反应(RT-PCR )( 法新社) ,白朊,和 alpha-fetoprotein 在不同房间人口被执行。结果:在指定文化条件下面,与 FLC co 有教养的老鼠 MSC 超过二个星期表示了白朊, CK-18,和 AFP-RNA。在 wk 3, MSC 失去了 hepatocytic 基因表示,可能由于 cocultured FLC 的增生。FLC 也在合作文化和一个很高的生长潜力显示出稳定的肝 specific 基因表情。结论:从骨髓的老鼠 MSC 能面对 FLC 在试管内区分 hepatocytic 房间,在合作文化的 MSC 的存在也为 FLC 的扩大和区别提供有益的环境。 | Claudia Lange Helge Bruns Dietrich Kluth Axel R Zander Henning C Fiegel | 2006 | World Journal of Gastroenterology2006，12，15： | 23 |
| 3 | Blue light is more essential than red light for maintaining the activities of photosystem Ⅱ and Ⅰ and photosynthetic electron transport capacity in cucumber leaves显示文摘Blue and red lights differently regulate leaf photosynthesis. Previous studies indicated that plants under blue light generally exhibit better photosynthetic characteristics than those under red light. However, the regulation mechanism of related photosynthesis characteristics remains largely unclear. Here, four light qualities treatments(300 μmol m–2 s–1) including white fluorescent light(FL), blue monochromatic light(B, 440 nm), red monochromatic light(R, 660 nm), and a combination of red and blue light(RB, R:B=8:1) were carried out to investigate their effects on the activity of photosystem II(PSII) and photosystem I(PSI), and photosynthetic electron transport capacity in the leaves of cucumber(Cucumis sativus L.) seedlings. The results showed that compared to the FL treatment, the R treatment significantly limited electron transport rate in PSII(ETRII) and in PSI(ETRI) by 79.4 and 66.3%, respectively, increased non-light induced non-photochemical quenching in PSII(ΦNO) and limitation of donor side in PSI(ΦND) and reduced most JIP-test parameters, suggesting that the R treatment induced suboptimal activity of photosystems and inhibited electron transport from PSII donor side up to PSI. However, these suppressions were effectively alleviated by blue light addition(RB). Compared with the R treatment, the RB treatment significantly increased ETRII and ETRI by 176.9 and 127.0%, respectively, promoted photosystems activity and enhanced linear electron transport by elevating electron transport from QA to PSI. The B treatment plants exhibited normal photosystems activity and photosynthetic electron transport capacity similar to that of the FL treatment. It was concluded that blue light is more essential than red light for normal photosynthesis by mediating photosystems activity and photosynthetic electron transport capacity. | MIAO Yan-xiu W ANG Xiao-zhuo G AO Li-hong C HEN Qing-yun QU Mei | 2016 | Journal of Integrative Agriculture2016，15，1： | 9 |
| 4 | ASYMPTOTIC BEHAVIOUR OF SUPERSONIC FLOW PAST ACONVEX COMBINED WEDGE显示文摘§1.IntroductionInthispaperwestudyuniformsupersonicflowpastacurvedwedgewithasmalvertexangle.Inthiscaseanatachedshockoccurs.The... | C HEN S HUXING * | 1998 | Chinese Annals of Mathematics,Series B1998，19，3： | 5 |
| 5 | Bcl-x_L and Myeloid cell leukaemia-1 contribute to apoptosis resistance of colorectal cancer cells显示文摘AIM: To explore the role of Bcl-xL and Myeloid cell leukaemia (Mcl)-1 for the apoptosis resistance of colorectal carcinoma (CRC) cells towards current treat-ment modalities. METHODS: Bcl-xL and Mcl-1 mRNA and protein ex-pression were analyzed in CRC cell lines as well as human CRC tissue by Western blot,quantitative PCRand immunohistochemistry. Bcl-xL and Mcl-1 protein expression was knocked down or increased in CRC cell lines by applying specific siRNAs or expression plas-mids,respectively. After modulation of protein expres-sion,CRC cells were treated with chemotherapeutic agents,an antagonistic epidermal growth factor recep-tor (EGFR1) antibody,an EGFR1 tyrosine kinase inhibi-tor,or with the death receptor ligand TRAIL. Apoptosis induction and cell viability were analyzed. RESULTS: Here we show that in human CRC tis-sue and various CRC cell lines both Bcl-xL and Mcl-1 are expressed. Bcl-xL expression was higher in CRC tissue than in surrounding non-malignant tissue,both on protein and mRNA level. Mcl-1 mRNA expression was significantly lower in ma-lignant tissues. However,protein expression was slightly higher. Viability rates of CRC cells were significantly decreased after knock down of Bcl-xL expression,and,to a lower extent,after knock down of Mcl-1 expression. Furthermore,cells with reduced Bcl-xL or Mcl-1 expression was more sensitive towards oxaliplatin-and irinotecan-induced apoptosis,and in the case of Bcl-xL also towards 5-FU-induced apoptosis. On the other hand,upregulation of Bcl-xL by transfec-tion of an expression plasmid decreased chemothera-peutic drug-induced apoptosis. EGF treatment clearly induced Bcl-xL and Mcl-1 expression in CRC cells. Apop-tosis induction upon EGFR1 blockage by cetuximab or PD168393 was increased by inhibiting Mcl-1 and Bcl-xL expression. More strikingly,CD95-and TRAIL-induced apoptosis was increased by Bcl-xL knock down. CONCLUSION: Our data suggest that Bcl-xL and,to a lower extent,Mcl-1,are important anti-apoptotic factors in CRC. Specific downregulation of Bcl-xL is a promising approach to sensitize CRC cells towards chemotherapy and targeted therapy. | Henning Schulze-Bergkamen Roland Ehrenberg Lothar Hickmann Binje Vick Toni Urbanik Christoph C Schimanski Martin R Berger Arno Schad Achim Weber Steffen Heeger Peter R Galle Markus Moehler | 2008 | World Journal of Gastroenterology2008，14，24： | 4 |
| 6 | Microbial production of 1 ,3-propanediol from glycerol by encapsulated Klebsiella pneumoniae显示文摘 | ZHAO Y N C HEN G YAO S J | 2006 | Biochemi- cal Engineering Journal2006，32，2： | 1 |
| 7 | Medical meth- ods for cervical ripening before the removal of in- trauterine devices in postmenopausal women: a systematic review 显示文摘 | Hou S P C'hen 0 J Huang L H | 2013 | Eur J Obstet Gynecol Reprod Biol2013，169，2： | 1 |
| 8 | Characteristics of hemicellulose, cellulose and lignin pyrolysis显示文摘 | Yang H Yan R C hen H | 2007 | Fuel2007，86，： | 1 |
| 9 | Urea for preservation of moist hay显示文摘 | Henning J C Dougherty C T Leary J | 1990 | Anim Feed Sci Technol1990，31，34： | 1 |
| 10 | Nanodiamond bioconjugate probes and their collection by electrophoresis 显示文摘 | Hens S C Cunningham G Tyler T | 2008 | Diamond Relat Mater2008，17，11： | 1 |
| 11 | On strongly connected Abelian group graphs显示文摘 | C HEN C C QUIMPO N | 1981 | Combinato-rial Math VIII Lecture Notes Series1981，884，： | 1 |
| 12 | Chemical methods and phytoremediation of soil contaminated with heavy metals显示文摘 | Hen H M Zheng C R Tu C | 2000 | Chemosphere2000，41，12： | 1 |
| 13 | Regulation of GFRa-1 and GFRa-2 mRNAs in rat brain by electroconvulsive seizure显示文摘 | HEN A C H EISCH A J SAKAI N | 2001 | Synapse2001，39，： | 1 |
| 14 | Magnetic anomalies in the Pacific and sea floor spreading显示文摘 | Pitman W C III Hen'on E M Heirtzler J R | 1968 | Journal of Geophysical Research1968，73，： | 1 |
| 15 | Beat shock proteins and atrial fibrillation显示文摘 | Henning R H van Gelder I C | 2007 | Cell Stress Chaperones2007，12，2： | 1 |
| 16 | Simultaneous determination of thia mphenicol, florfenicol and florfenicol amine in swine muscle by liquid chromatography tandem mass spectrometry with immunoaffinity chromatography clean-up显示文摘 | Luo P Hen X Linag C | 2010 | Journal of Chromatography B2010，878，2： | 1 |
| 17 | Temporal and mechanistic tracking of cellular uptake dynamics with novel surface fluorophore-bound nanodiamonds 显示文摘 | Schrand A M Lin J B Hens S C | 2011 | Nanoscale2011，3，2： | 1 |
| 18 | Physiological decre- ments during sustained military operational stress显示文摘 | Henning P C Park B S Kim J S | 2011 | Mil Med2011，176，9： | 1 |
| 19 | Solar air conditioning in Europe-an overview显示文摘 | Balaras C A Grossman G Henning H M | 2007 | Renewable and Sustainable Energy Reviews2007，11，2： | 1 |
| 20 | Liver-specific dene expression in cultured human hepmatopoietic stem cell显示文摘 | HENNING C F MICHAEL V L LOURDES C D | 2003 | Stem Cells2003，21，： | 1 |
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