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| 1 | Assessment of health benefit of PM_(2.5) reduction during COVID-19 lockdown in China and separating contributions from anthropogenic emissions and meteorology显示文摘The national lockdown policies have drastically disrupted socioeconomic activities during the COVID-19 pandemic in China,which provides a unique opportunity to investigate the air quality response to such anthropogenic disruptions.And it is meaningful to evaluate the potential health impacts of air quality changes during the lockdown,especially for PM_(2.5) with adverse health effects.In this study,by using PM_(2.5) observations from 1388 monitor-ing stations nationwide in China,we examine the PM_(2.5) variations between the COVID-19 lockdown(February and March in 2020)and the same period in 2015-2019,and find that the national average of PM_(2.5) decreases by 18 μg/m^(3),and mean PM_(2.5) for most sites(about 75%)decrease by 30%-60%.The anthropogenic and meteorological contributions to these PM_(2.5) variations are also determined by using a stepwise multiple linear regression(MLR)model combined with the Kolmogorov-Zurbenko filter.Our results show that the change of anthropogenic emissions is a leading contributor to those widespread PM_(2.5) reductions,and meteorological conditions have the negative influence on PM_(2.5) reductions for some re-gions,such as Beijing-Tianjin-Hebei(BTH).Additionally,the avoided premature death due to PM_(2.5) reduction is estimated as a predicted number based on a log-linear concentration-response function.The total avoided premature death is 9952 in China,with dominant con-tribution(94%)from anthropogenic emission changes.For BTH,Yangtze River Delta,Pearl River Delta and Hubei regions,the reductions of PM_(2.5) are 24.1,24.3,13.5 and 29.5 μg/m^(3),with the avoided premature deaths of 1066,1963,454 and 583,respectively. | Heming Bai Wenkang Gao Yuanpeng Zhang Li Wang | 2022 | Journal of Environmental Sciences2022，34，5： | 0 |
| 2 | Research advances in peptide-drug conjugates显示文摘Peptide-drug conjugates(PDCs)are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavable linker.As an emerging prodrug strategy,PDCs not only preserve the function and bioactivity of the peptides but also release the drugs responsively with the cleavable property of the linkers.Given the ability to significantly improve the circulation stability and targeting of drugs in vivo and reduce the toxic side effects of drugs,PDCs have already been extensively applied in drug delivery.Herein,we review the types and mechanisms of peptides,linkers and drugs used to construct PDCs,and summarize the clinical applications and challenges of PDC drugs. | Liming Gong Heming Zhao Yanhong Liu Hao Wu Chao Liu Shuangyan Chang Liqing Chen Mingji Jin Qiming Wang Zhonggao Gao Wei Huang | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 3 | Multi-scale analysis on the pulverized coal flow behaviors under high,pressure dense-phase pneumatic conveying显示文摘To deeply knowledge of the flow behaviors of pulverized coal particles in dense gas-solid two-phase flow,a multi-scale analysis method based on electrostatic sensor array is applied for the multi-scale characterization of flow behaviors of dense gas-solid flow.The experimental results indicate that:for steady flow,with the increment of conveying pressure difference,the individual particles increase and the particle clusters decrease,the individual particle distribution is always inhomogeneous but the particle cluster distribution tends to be more homogeneous over the cross-section of pipe,while the average flow behavior of pulverized coal particles is always in the relatively static state.For unsteady flow,the average flow behavior of pulverized coal particles is dynamic,and the flow behaviors of the multi-scale flow structures over the cross-section of pipe are all significantly inhomogeneous.Moreover,the effect of particle size on flow behavior of pulverized coal is also investigated and validated. | Heming Gao Xiaojuan Wang Qi Chang | 2022 | Particuology2022，20，1： | 0 |
| 4 | Histamine H1 Receptor in Basal Forebrain Cholinergic Circuit:A Novel Target for the Negative Symptoms of Schizophrenia?显示文摘Schizophrenia is a common and severe mental disorder with a lifetime prevalence of~1%[1]Apart from the typical positive symptoms,such as hallucinations and delusions,which mainly make patients seek medication,60%-70%of patients are tortured by negative symptoms(e.g.apathy and alogia)and cognitive deficits that impose a long-term burden on patients[2]. | Shuangshuang Wu Chenshu Gao Feng Han Heming Cheng | 2022 | Neuroscience Bulletin2022，38，5： | 0 |
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