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| 1 | 大数据升级制造企业供应链管理显示文摘'中国制造2025'战略,让中国制造业开始了从'中国制造'到'中国智造'的转型之路,意味着传统制造企业必须实现智能制造的转型升级来应对来自市场的机遇和挑战。智能制造作为'中国制造2025'的核心,以制造技术的数字化、智能化为重点,通过互联网与制造融合,运用工业大数据技术帮助传统制造业转型为数字化企业。如何利用大数据驱动智能工业,助力中国企业从'中国制造'走向'中国智造'成为制造业不可回避的迫切挑战。 | Helmuth Ludwig | 2015 | 互联网经济2015，，7： | 7 |
| 2 | Therapeutic ACPA inhibits NET formation: a potential therapy for neutrophil-mediated inflammatory diseases显示文摘Excessive release of neutrophil extracellular traps(NETs)is associated with disease severity and contributes to tissue injury,followed by severe organ damage.Pharmacological or genetic inhibition of NET release reduces pathology in multiple inflammatory disease models,indicating that NETs are potential therapeutic targets.Here,we demonstrate using a preclinical basket approach that our therapeutic anti-citrullinated protein antibody(tACPA)has broad therapeutic potential.Treatment with tACPA prevents disease symptoms in various mouse models with plausible NET-mediated pathology,including inflammatory arthritis(IA),pulmonary fibrosis,inflammatory bowel disease and sepsis.We show that citrulline residues in the N-termini of histones 2A and 4 are specific targets for therapeutic intervention,whereas antibodies against other N-terminal post-translational histone modifications have no therapeutic effects.Because citrullinated histones are generated during NET release,we investigated the ability of tACPA to inhibit NET formation.tACPA suppressed NET release from human neutrophils triggered with physiologically relevant human disease-related stimuli.Moreover,tACPA diminished NET release and potentially initiated NET uptake by macrophages in vivo,which was associated with reduced tissue damage in the joints of a chronic arthritis mouse model of IA.To our knowledge,we are the first to describe an antibody with NET-inhibiting properties and thereby propose tACPA as a drug candidate for NET-mediated inflammatory diseases,as it eliminates the noxious triggers that lead to continued inflammation and tissue damage in a multidimensional manner. | Renato G.S.Chirivi Jos W.Gvan Rosmalen Maarten van der Linden Maximilien Euler Gonny Schmets Galina Bogatkevich Konstantinos Kambas Jonas Hahn Quinte Braster Oliver Soehnlein Markus H.Hoffmann Helmuth H.Gvan Es Jos M.H.Raats | 2021 | Cellular & Molecular Immunology2021，18，6： | 5 |
| 3 | Localized Corrosion Characteristics of Nickel Alloys: A Review显示文摘There are a great variety of commercial nickel alloys mainly because nickel is able to dissolve a large amount of alloying elements while maintaining a single ductile austenitic phase.Nickel alloys are generally designed for and used in highly aggressive environments,for example,those where stainless steels may experience pitting corrosion or environmentally assisted cracking.While nickel alloys are generally resistant to pitting corrosion in chloride-containing environments,they may be prone to crevice corrosion attack.Addition of chromium,molybdenum and tungsten increases the localized corrosion resistance of nickel alloys.This review on the resistance to localized corrosion of nickel alloys includes specific environments such as those present in oil and gas upstream operations,in the chemical process industry and in seawater service. | Helmuth Sarmiento Klapper Natalia S. Zadorozne Raul B. Rebak | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，4： | 3 |
| 4 | RANKL/RANK control Brca1 mutation-driven mammary tumors显示文摘 | Verena Sig Kwadwo Owusu-Boaitey Puma A Joshi Anoop Kavirayani Gerald Wimsberger Maria Novatchkova Ivona Kozieradzki Daniel Schramek Nnamdi Edokobi Jerome Hersl Aishia Sampson Ashley Odai-Afotey Conxi Lazaro Eva Gonzalez-Suarez Miguel A Pujaaa for CIMBA Holger Heyn Enrique Vidal Jennifer Cru. ickshank Hal Berman Renu Sarao Melita Tieevic Iris Uribesalgo Luigi Tortola Shuan Rao Yen Tan Georg Pfeiler Eva YHP Lee Zsuzsanna Bago-Horvath Lukas Kenner Helmuth Popper Christian Singer Rama Khokha LaundeRe P Jones Josef M Penninger | 2016 | Cell Research2016，26，7： | 3 |
| 5 | The construction of generalized B-spline low-pass filters related to possibility density显示文摘Starting from piecewise constant functions, a novel family of generalized symmetric B-splines, with realizable ideal low-pass filters, are constructed. The first order generalized B-spline low-pass filter is closely related to functions analytic in a neighborhood of the unit disc and the generalized sinc functions. The properties of this kind of low-pass filters are investigated. The behavior of the generalized B-spline low-pass filter related to normalized Gaussian distribution is considered. | CHEN QiuHui LI LuoQing MALONEK Helmuth | 2012 | Science China Mathematics2012，55，12： | 2 |
| 6 | The Double Dividend of Postponing Retirement显示文摘 | Helmuth Cremer Pierre Pestieau | 2003 | International Tax and Public Finance2003，，4： | 2 |
| 7 | Theory of volume changes in hardened portland cement paste during freezing 显示文摘 | POWERS T C HELMUTH R A | 1953 | Proc Highway Res Board1953，32，： | 2 |
| 8 | Sonochemical Synthesis of Highly Luminescent Zinc Oxide Nanoparticles Doped with Magnesium(II)显示文摘 | Huan‐Ming Xiong Dmitry G. Shchukin Helmuth M?hwald Yang Xu Yong‐Yao Xia | 2009 | Angew. Chem. Int. Ed2009，，15： | 2 |
| 9 | Melamine formaldehyde core decomposition as the key step controlling capsule integrity:Optimizing the polyelectrolyte capsulefabrication显示文摘 | Gao Changyou Edwin Donath Helmuth M o¨ hwald | 2002 | Chem Phys2002，203，7： | 1 |
| 10 | Stem cells hear call of injured tissue显示文摘 | Helmuth L | 2001 | Science2001，294，： | 1 |
| 11 | Environmental taxation, tax competition, and harmonization显示文摘 | Helmuth Cremer Firouz Gahvari | 2004 | Journal of Urban Economics2004，，1： | 1 |
| 12 | Biophysics, physiological ecology, and climate change: does mechanism matter? 显示文摘 | Helmuth B Kingsolver J G Carrington E | 2005 | Annual Review of Physiology2005，67，1： | 1 |
| 13 | Theory of Volume Change in Hardened Portland Cement Pastes During Freezing显示文摘 | Powers T C Helmuth R A | 1953 | Proceedings of the Highway Research Board1953，，32： | 1 |
| 14 | Rapid classification and identification of Salmonellae at the species and subspecies levels by whole-cell matrix-assisted laser desorption ionization-time of flight mass spectrometry 显示文摘 | RAIF DIECKMANN REINER HELMUTH MARCEL ERHARD | 2008 | Appl Environ Microbiol2008，74，24： | 1 |
| 15 | Fatigue Life Prediction of a Railway Bogie under Dynamic Loads through Simulation显示文摘 | Stefan Dietz Helmuth Netter Dell Sachau | 1998 | Vehicle Systems Dynamics Supplement1998，29，： | 1 |
| 16 | Fully automatic determination and optimization of engine control characteristics显示文摘 | Hochschwartzer Helmuth | | SAE Paper0，，： | 1 |
| 17 | Addiction:beyond the pleasure principle 显示文摘 | Laura Helmuth | 2001 | Science2001，294，： | 1 |
| 18 | Click Che- mistry on Surfaces : 1,3-Dipolar Cycloaddition Reactions of Azide-terminated Monolayers on Silica 显示文摘 | THOMAS Lummerstorfer HELMUTH Hoffmann | 2004 | The Journal of Physical Chemistry B2004，108，13： | 1 |
| 19 | concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer显示文摘 | Arlene AF Helmuth G Moshe MM | 2003 | N Eng J Med2003，349，22： | 1 |
| 20 | Click chemistry on surfaces:1,3-dipolar cycloaddition reactions of azide-terminated monolayers on silica显示文摘 | Thomas Lummerstorfer Helmuth Hoffmann | 2004 | Journal of Physical Chemistry B2004，108，13： | 1 |
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