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| 1 | Genetic Advances in Genome and Phenotypic Characters of Domestic Dog显示文摘Dogs represent such a rich potential resource to further understand diseases and genetic traits.Comparing the genomes of three species of canine,human,and rat in terms of genome analysis,it is found that dogs are highly conservative with humans and rats.The special population structure of dogs makes it a good model for studying the diversity of morphology and behavior,the genetic basis of mammalian evolution,and dis-eases.This article gives a brief review of recent advances in domestic dog origin and evolution,genomic structure,genetic variation in dog pheno-typic characteristics,and gene mapping.These research results are expected to provide a better theoretical basis for canine genetic breeding re-search and provide new ideas and methods for the prevention,diagnosis and treatment of human diseases. | Li Jing Wan Jiusheng Chen Chao Deng Weidong Yue Rui Xiong Heli Li Liguang | 2020 | Animal Husbandry and Feed Science2020，12，2： | 0 |
| 2 | Mechanism of activation and biased signaling in complement receptor C5aR1显示文摘The complement system plays an important role in the innate immune response to invading pathogens.The complement fragment C5a is one of its important effector components and exerts diverse physiological functions through activation of the C5a receptor 1(C5aR1)and associated downstream G protein andβ-arrestin signaling pathways.Dysfunction of the C5a-C5aR1 axis is linked to numerous inflammatory and immune-mediated diseases,but the structural basis for activation and biased signaling of C5aR1 remains elusive.Here,we present cryo-electron microscopy structures of the activated wild-type C5aR1–Gi protein complex bound to each of the following:C5a,the hexapeptidic agonist C5apep,and the G protein-biased agonist BM213.The structures reveal the landscape of the C5a–C5aR1 interaction as well as a common motif for the recognition of diverse orthosteric ligands.Moreover,combined with mutagenesis studies and cell-based pharmacological assays,we deciphered a framework for biased signaling using different peptide analogs and provided insight into the activation mechanism of C5aR1 by solving the structure of C5aR1I116A mutant–Gi signaling activation complex induced by C089,which exerts antagonism on wild-type C5aR1.In addition,unusual conformational changes in the intracellular end of transmembrane domain 7 and helix 8 upon agonist binding suggest a differential signal transduction process.Collectively,our study provides mechanistic understanding into the ligand recognition,biased signaling modulation,activation,and Gi protein coupling of C5aR1,which may facilitate the future design of therapeutic agents. | Yuying Feng Chang Zhao Yue Deng Heli Wang Liang Ma Sicen Liu Xiaowen Tian Bo Wang Yan Bin Peipei Chen Wei Yan Ping Fu Zhenhua Shao | 2023 | Cell Research2023，33，4： | 0 |
| 3 | In-situ sugar-templated porous elastomer sensor with high sensitivity for wearables显示文摘Fabrication of elastic pressure sensors with low cost,high sensitivity,and mechanical durability is important for wearables,electronic skins and soft robotics.Here,we develop high-sensitivity porous elastomeric sensors for piezoresistive and capacitive pressure detection.Specifically,a porous polydimethylsiloxane(PDMS)sponge embedded with conductive fillers of carbon nanotubes(CNTs)or reduced graphene oxide(rGO)was fabricated by an in-situ sugar template strategy.The sensor demonstrates sensitive deformation to applied pressure,exhibiting large and fast response in resistance or capacitance for detection of a wide range of pressure(0‒5 kPa).PDMS,as a high-elasticity framework,enables creation of sensors with high sensitivity,excellent stability,and durability for long-term usage.The highest sensitivities of 22.1 and 68.3 kPa−1 can be attained by devices with 5%CNTs and 4%rGO,respectively.The geometrics of the sponge sensor is tailorable using tableting technology for different applications.The sensors demonstrate finger motion detection and heart-rate monitoring in real-time,as well as a capacitive sensor array for identification of pressure and shape of placed objects,exhibiting good potential for wearables and human-machine interactions. | Meng REN Ying FANG Yufan ZHANG Heli DENG Desuo ZHANG Hong LIN Yuyue CHEN Jiaqing XIONG | 2022 | Frontiers of Materials Science2022，16，2： | 0 |
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