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| 1 | MGMT and PTEN as potential prognostic markers in breast cancer显示文摘 | Julio Cirullo Neto Mariana Mari Ikoma Katia Candido Carvalho José Vassallo Marina De Brot Helenice Gobbi Fernando Augusto Soares Rafael Malagoli Rocha | 2011 | Experimental and Molecular Pathology2011，，1： | 1 |
| 2 | Immunohistochemical expression of p63 in pleomorphic adenomas and carcinomas ex-pleomorphic adenomas of salivary glands显示文摘 | Marisa Cristina Leite Santos Genelhu Helenice Gobbi Fernando Augusto Soares Ant?nio Hugo José Froes de Marques Campos Carlos Alberto Ribeiro Geovanni Dantas Cassali | 2005 | Oral Oncology2005，，2： | 1 |
| 3 | Major and trace ele-ments of sDeam sediments from the lowermost Amazon River显示文摘 | Helenice Vital Karl Stattegger | 2000 | Chemical Geology2000，168，： | 1 |
| 4 | MGMT and PTEN as potential prognostic markers in breast cancer显示文摘 | Julio Cirullo Neto Mariana Mari Ikoma Katia Candido Carvalho José Vassallo Marina De Brot Helenice Gobbi Fernando Augusto Soares Rafael Malagoli Rocha | 2011 | Experimental and Molecular Pathology2011，，1： | 1 |
| 5 | Cytokinins and auxin communicate nitrogenavailability as long-distance signal molecules in pineapple(Ananascomosus)显示文摘 | Vivian T Helenice M | 2007 | Journal of Plant Physiology2007，164，： | 1 |
| 6 | MGMT and PTEN as potential prognostic markers in breast cancer显示文摘 | Julio Cirullo Neto Mariana Mari Ikoma Katia Candido Carvalho José Vassallo Marina De Brot Helenice Gobbi Fernando Augusto Soares Rafael Malagoli Rocha | 2011 | Experimental and Molecular Pathology2011，，1： | 1 |
| 7 | Detection of Helicobacter pylori resistance to clarithromycin and fluoroquinolones in Brazil:A national survey显示文摘AIM To evaluate bacterial resistance to clarithromycin and fluoroquinolones in Brazil using molecular methods.METHODS The primary antibiotic resistance rates of Helicobacter pylori(H. pylori) were determined from November 2012 to March 2015 in the Southern,South-Eastern,Northern,North-Eastern,and Central-Western regions of Brazil. Four hundred ninety H. pylori patients [66% female,mean age 43 years(range: 18-79)] who had never been previously treated for this infection were enrolled. All patients underwent gastroscopy with antrum and corpus biopsies and molecular testing using Geno Type Helico DR(Hain Life Science,Germany). This test was performed to detect the presence of H. pylori and to identify point mutations in the genes responsible for clarithromycin and fluoroquinolone resistance. The molecular procedure was divided into three steps: DNA extraction from the biopsies,multiplex amplification,and reverse hybridization. RESULTS Clarithromycin resistance was found in 83(16.9%) patients,and fluoroquinolone resistance was found in 66(13.5%) patients. There was no statistical difference in resistance to either clarithromycin or fluoroquinolones(P = 0.55 and P = 0.06,respectively) among the different regions of Brazil. Dual resistance to clarithromycin and fluoroquinolones was found in 4.3%(21/490) of patients. The A2147 G mutation was present in 90.4%(75/83),A2146 G in 16.9%(14/83) and A2146 C in 3.6%(3/83) of clarithromycin-resistant patients. In 10.8%(9/83) of clarithromycin-resistant samples,more than 01 mutation in the 23 S r RNA gene was noticed. In fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. D91 N mutation was observed in 34.8%(23/66),D91 G in 18.1%(12/66),N87 K in 16.6%(11/66) and D91 Y in 13.6%(9/66) of cases. Among fluoroquinolone-resistant samples,37.9%(25/66) showed mutations not specified by the Geno Type Helico DR test. CONCLUSION The H. pylori clarithromycin resistance rate in Brazil is at the borderline(15%-20%) for applying the standard triple therapy. The fluoroquinolone resistance rate(13.5%) is equally concerning. | Bruno Squarcio Sanches Gustavo Miranda Martins Karine Lima Bianca Cota Luciana Dias Moretzsohn Laercio Tenorio Ribeiro Helenice P Breyer Ismael Maguilnik Aline Bessa Maia Joffre Rezende-Filho Ana Carolina Meira Henrique Pinto Edson Alves Ramiro Mascarenhas Raissa Passos Julia Duarte de Souza Osmar Reni Trindade Luiz Gonzaga Coelho | 2016 | World Journal of Gastroenterology2016，22，33： | 1 |
| 8 | Endogenous auxin and cytokinin contents associated with shoot formation in leaves of pineapple cultured in vitro显示文摘 | HELENICE M BEATRIZ M S JANE E K REGINA M H BRUNO S | 2003 | Braz J Plant Physiol2003，15，： | 1 |
| 9 | Composition and trace element geochemistry of detrital clay and heavy mineral suits of the lowermost Amazon River: A Provenance Study 显示文摘 | Helenice V Stattegger K Garbe-Schonberg C D | 1999 | Journal of Sediment Research1999，69，3： | 1 |
| 10 | An Overview of Oligocene to Recent Sediments of the Western Pacific Warm Pool(WPWP)(International Ocean Discovery Program-IODP Exp.363)Using Warm and Cool Foraminiferal Species显示文摘We use the excellent sediment recovery of International Ocean Discovery Program(IODP)Exp.363,in the Western Pacific Warm Pool(WPWP)to assess down-core variations in the abundance of warm versus cool benthic foraminiferal species through a warm benthic foraminifers(WBF)curve.The total percentage of the“warm”shallower species group(Laticarinina pauperata,Cibicidoides kullenbergi,C.robertsonianus,Cibicidoides sp.,Hoeglundina elegans,and Bulimina aculeata)and of the“cool”species group from deep waters(Pyrgo murrhina,Planulina wuellerstorfi,Uvigerina peregrina,and Globobulimina hoeglundi,Hopkinsina pacifica)at all sites is used to assess paleo temporal and spatial variations in preservation and marine temperature.Our study sites span water depths ranging from 875 m to 3421 m and our results indicate that well-preserved living and fossil foraminifera characterize mudline and core sediments at all water depths attesting the wide environmental tolerance of these species to temperature and pressure.Using magneto-and biostratigraphy datum,these sediments are of Oligocene age.Our low-resolution study showed that with the exception of core 1486B which the linear tendency of warmer species is toward cool sediments in old times,all of them show that older sediments indicate warmer periods than today,which is expected from Miocene to Recent.Our results provide evidence for the preservation potential of deeply buried sediments,which has implications on climate reconstructions based on the population dynamics of calcareous benthic foraminifera. | Patrícia Pinheiro Beck Eichler Christofer Paul Barker Moab Praxedes Gomes Helenice Vital | 2021 | Journal of Marine Science2021，3，3： | 0 |
| 11 | Barretts 组织变形的诊断和管理: 什么是新的显示文摘 Barrett’s esophagus(BE) is a complication of gastroesophageal reflux disease,and a premalignant lesion for esophageal adenocarcinoma(EAC).Observational studies suggest that endoscopic surveillance is associated with the detection of dysplasia and EAC at an early stage along with improved survival,but controversies still remain.The management of patients with BE involves endoscopic surveillance,preventive and clinical measures for cancer,and endoscopic and surgical approaches to treatment.Deciding upon the most appropriate treatment is a challenge.This study presents the results and the effectiveness of these practices. | Fábio Segal Helenice Pankowski Breyer | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，9： | 0 |
| 12 | Bedrock control on the Assu Incised Valley morphology and sedimentation in the Brazilian Equatorial Shelf显示文摘Assu 切入山谷(AIV ) 一个切入山谷的系统的一个新例子位于巴西赤道的大陆人架。这条山谷从今日的海岸线扩大超过 40 km 到架裂缝,在一个被动边缘背景,在上一浅(~ 70 m ) ,狭窄(43 km ) 并且扁平(? 1 吗?? | Moab Praxedes Gomes Helenice Vital Karl Stattegger Klaus Schwarzer | 2016 | International Journal of Sediment Research2016，31，2： | 0 |
| 13 | Evolution on the Water Quality in Sergipe Hinterland Reservoirs, Northeast Brazil显示文摘 | Carlos Alexandre Borges Garcia Anairam Piedade de Souza Melol Helenice Leite Garcia Cristiane da CunhaNascimento Silvanio Silvario Lopes da Costa Maria Caroline Silva Mendonaa Jose do Patrocinio Hora Alves Marcus Aure1io Soares Cruz Rennan Geovanny Oliveira Araujo | 2017 | Journal of Environmental Science and Engineering(B)2017，6，7： | 0 |
| 14 | On the Impact of Brazil's Largest Recent Oil Spill on Regional Oceans显示文摘In 2019,an oil spill in Brazil,of unknown origin,severely impacted coastal environs with the worst environmental disaster ever recorded in any tropical coastal region globally severely damaging South Pirangi Reef area in the state of Rio Grande do Norte(RN).Here we discuss acute and chronic impacts including chemical contamination and economic consequences all over the world and show some evidence of the oil spill in this biodiverse area.Moreover,the lapse between the moment of the disastei;and the action to manage it,was hampered by a political agenda coinciding with local and global tragedies that redirected public attention.Meanwhile almost 2 years have passed still without the offending party identification or culpability;and poor communities may continue to absorb its deleterious impacts for decades without consideration or compensation.This disaster occurred during the Brazilian government's current issues involving extensive environmental mismanagement,resulting in a slow response from an inept system.It is with urgent necessity to spotlight this tragedy in this unique and sensitive reef habitat experiencing the ongoing damaging effects that include socio-economic losses not yet addressed. | Liana de Figueiredo Mendes Patricia Pinheiro Beck Eichler Tatiana Leite Ana Beatriz Alves Bennemann Clara de Souza Melo Andressa Lima Ferreira Khalil Bow Ltaif Garcia Luzia Liniane do Nascimento Silva Christofer Paul Barker Helenice Vital Moab Praxedes Gomes Priscila F.M.Lopes | 2021 | Sustainable Marine Structures2021，3，2： | 0 |
| 15 | Optimization in the Selection of Sugarcane Varieties in a Sucro Energy Plant Located in the State of Sao Paulo,Brazil显示文摘Sugarcane crops have undergone several changes with the intensification of agricultural machinery in Brazil in the last years.This occurs,mainly,due to the transfer of the semi-mechanized system to the mechanized one during harvest operations.Thus,studies are needed on the optimization of sugarcane production in relation to mechanized processes,since it is necessary to verify the adaptability of sugarcane varieties to the mechanization of the plantation.This study aimed to develop and apply a mathematical model of optimization to select sugarcane varieties that maximize production and meet the quality standards required by the industry for sugar and fiber contents.The data were collected in a sugarcane mill located in the interior of S?o Paulo state.The result obtained by the optimization process evinced an increase of 16.65%when compared to the productivity of the initial scenario. | Ricardo Ghantous Cervi Helenice de Oliveira Florentino Silva Ernée Kozyreff Filho Gislaine Cristina Batistela Danilo Simoes | 2020 | Journal of Agricultural Science and Technology(B)2020，10，1： | 0 |
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