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您的检索式：作者名="Helene Leclerc"
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| 1 | TRPC3 is required for the survival, pluripotency and neural differentiation of mouse embryonic stem cells(mESCs)显示文摘Transient receptor potential canonical subfamily member 3(TRPC3) is known to be important for neural development and the formation of neuronal networks. Here, we investigated the role of TRPC3 in undifferentiated mouse embryonic stem cells(mESCs) and during the differentiation of mESCs into neurons. CRISPR/Cas9-mediated knockout(KO) of TRPC3 induced apoptosis and the disruption of mitochondrial membrane potential both in undifferentiated mESCs and in those undergoing neural differentiation. In addition, TRPC3 KO impaired the pluripotency of mESCs. TRPC3 KO also dramatically repressed the neural differentiation of mESCs by inhibiting the expression of markers for neural progenitors, neurons, astrocytes and oligodendrocytes.Taken together, our new data demonstrate an important function of TRPC3 with regards to the survival, pluripotency and neural differentiation of mESCs. | Helen Baixia Hao Sarah E. Webb Jianbo Yue Marc Moreau Catherine Leclerc Andrew L. Miller | 2018 | Science China(Life Sciences)2018，61，3： | 3 |
| 2 | 日粮中添加过瘤胃保护B族维生素对奶牛健康、产奶量和繁殖性能的影响显示文摘围产期日粮中添加过瘤胃保护B族维生素对奶牛健康、产奶量和繁殖性能都会产生影响。试验结果表明,添加过瘤胃保护B族维生素可以显著降低刚分娩奶牛亚临床酮病的发病率、奶牛平均人工授精成本以及泌乳190天内的淘汰率(P<0.05);显著增加乳脂率和泌乳150天怀孕率(P<0.05);胎衣不下的发病率从18.5%减少到16.0%,但是差异不显著。这说明在围产期日粮中添加过瘤胃保护B族维生素可以提高牛奶乳脂率、奶牛健康状况以及繁殖性能,并能为奶牛场节省成本,提高经济效益。 | Essi Evan Helene Leclerc Stacy Wrinkle 詹小立 阳成波 | 2015 | 中国乳业2015，，8： | 2 |
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