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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Antitumor activity against established intracerebral gliomas exhibited by cytotoxic T lympho-cytes, but not by lymphokine-activated killer cells 显示文摘 | Holladay FP Heitz T Wood GW | 1992 | J Neurosurg1992，77，5： | 1 |
| 3 | Characterization of nano-composite oxide ceramics and monitoring of oxide thin film growth by laser-induced breakdown spectroscopy 显示文摘 | PEDARNIG J D HEITZ J STEHRER T | 2008 | Spectrochimica Acta Part B: Atomic Spectroscopy2008，63，10： | 1 |
| 4 | Pulsed-laser deposition of crystalline Teflon (PTFE) films 显示文摘 | Li S T Arenholz E Heitz J | 1998 | Applied Surface Science1998，125，： | 1 |
| 5 | Quantitative study of C-H bonding in polymerlike amorphous carbon films using in situ infrared ellipsometry显示文摘 | HEITZ T DREVILLON B GODET C | 1998 | Phys Revs B1998，58，13： | 1 |
| 6 | Pulsed-laser Deposition of Crystalline Teflon (PTFE) Films显示文摘 | Arenholz E Heitz J | 1998 | Applied Surface Science1998，125，1： | 1 |
| 7 | Fluid experimental flow estimation based on an optical-flow scheme显示文摘 | Corpetti T Heitz D Arroyo G | | 0，，01： | 1 |
| 8 | Complexworking memory span tasks and higher-order cogni-tion: A laten-variable analysis of the relationship be-tween processing and storage 显示文摘 | Unsworth N Redick T S’Heitz R P | 2009 | Memory2009，17，6： | 1 |
| 9 | Characterizationof Vitis vinifera NPR1 homologs involved in the regulation of patho-genesis-related gene expression 显示文摘 | LE HENANFF G HEITZ T MESTRE P | 2009 | BMC Plant Biology2009，9，： | 1 |
| 10 | Successful treatment of a maligment rat glioma with cytotoxic T lymphocytes显示文摘 | Holladay FP Heitz T Chen YL | 1992 | Neurosurgery1992，31，： | 1 |
| 11 | A gene encoding a chloroplast-targeted lipoxygenase in tomato leaves is transientlyinduced by wounding,systemin, and methyl jasm onate显示文摘 | HEITZ T BERGEY D R RYAN C A | 1997 | Plant Physiology1997，114，： | 1 |
| 12 | Successful treatment of a malignant rat glioma with cytotoxic T lymphocytes显示文摘 | Heitz T Chen YL | 1992 | Neurosurgery1992，31，2： | 1 |
| 13 | Voumetric quantitative computed tomography of the promirnal femur: precision and relation to bone strength显示文摘 | Lang T F Keyak J H Heitz M W | 1997 | Bone1997，21，1： | 1 |
| 14 | Pulsed-laser deposition of crystalline teflon (PTFE) films 显示文摘 | Li S T Arenholz E Heitz J | 1998 | Applied Surface Science1998，125，1： | 1 |
| 15 | Plant 'pathogenesis-related' proteins and their role in defense against pathogens显示文摘 | Stintzi A Heitz T Prasad V | 1993 | Biochimie1993，75，： | 1 |
| 16 | Synthesis of poly(Bisphenol- A carbonate) - graft- polystyrene via the macromonomer technique显示文摘 | Rohrbach P Heitz T Keul H | 1993 | Makromoleculare Chemie- rnacromolecular Chemistry and Physics1993，194，6： | 1 |
| 17 | Characterization of nano-composite oxide ceramics and monitoring of oxide thin film growth by laser-induced breakdown spectroscopy显示文摘 | Pedarnig J D Heitz J Stehrer T | 2008 | Spectrochimica Acta Part B:Atomic Spectroscopy2008，63，10： | 1 |
| 18 | Character- ization of Vit vinera NPRI homologs involved in the regulation of pathogenesis-related gene ex- pression 显示文摘 | Le Henanff G Heitz T Mestre P | 2009 | BMC Plant Biology2009，9，1： | 1 |
| 19 | Effects of music therapy in the postanesthesia care unit:A nursing intervention显示文摘 | Heitz L Symreng T Scamman F L | 1992 | Post Anesth Nurs1992，7，1： | 1 |
| 20 | Synthesis of a bis-mae- rocycle containing two back-to-back rigidly connected 1, 10-phenanthroline units as a central core and its incorpo- ration, in a handcuff-like catenane显示文摘 | Frey J Kraus T Heitz V et a/ | 2007 | Chemistry-A Euro- pean Journal2007，13，： | 1 |
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