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| 1 | Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis显示文摘AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion colitis.METHODS:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or saline.Enemas were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical procedure.Follow-up colonoscopy was performed every 4 wk for 12 wk.The effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent assay.RESULTS:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus discharge.Treatment with either glutamine or butyrate induced significant reductions in both colonoscopic(P < 0.02) and histological scores(P < 0.01) and restored the densities of collagen fibers in tissue(P = 0.015;P = 0.001),the number of goblet cells(P = 0.021;P = 0.029),and the rate of apoptosis within the epithelium(P = 0.043;P = 0.011) to normal values.The high levels of cytokines in colon explants from rats with diversion colitis significantly decreased to normal values after treatment with butyrate or glutamine.CONCLUSION:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis. | Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller Morgana TL Castelo-Branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider | 2012 | World Journal of Gastroenterology2012，18，32： | 9 |
| 2 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 3 | Corporate debt maturity and the real effects of the 2007 credit cri- sis显示文摘 | Heitor A Campello M Laranjeira B | 2012 | Critical Finance Review2012，1，1： | 1 |
| 4 | Antioxidant activity of( + )-bergenin-a phytoconstituent isolated from the bark of Sacoglottis uchi Huber ( Humi- reaceae) 显示文摘 | Heitor A De Abreu Izandina Aparecida dos S Lago Gilmar P Souza | 2008 | Organ Biomol Chem2008，6，： | 1 |
| 5 | Data Mining With an Ant Colony Optimization Algorithm 显示文摘 | Rafael S ParpineUi Heitor S Lopes Alex A Freitas | 2002 | IEEE Transactions on Evolutionary Computing2002，6，4： | 1 |
| 6 | Powerful CEOs and Their Impact on Corporate Performance显示文摘 | Adams R B Heitor A Daniel F | 2005 | The Review of Financial Studies2005，18，4： | 1 |
| 7 | Aerosol particle deposition and distribution in bifurcating ventilation ducts 显示文摘 | Ant'onio F Miguel A Heitor Reis Murat Aydin | 2004 | Journal of Hazardous Materials2004，，： | 1 |
| 8 | Influences of cosmic radiation,artificial radioactivity an aerosol concentration upon the fair-weather atmospheric electric field in Lisbon (1995-1991)显示文摘 | Claudia Serrano A Heitor Reis Rui Rosa | 2006 | Atmospheric Research2006，81，： | 1 |
| 9 | Understanding the Relationship between Founder-CEOs and Firm Performance 显示文摘 | Adams R Heitor A Daniel F | 2009 | Journal of Empirical Finance2009，，1： | 1 |
| 10 | Powerful CEOs and their Impact on Corporate Performance显示文摘 | Adams Renee Heitor A|meida and Daniel Ferreira | 2005 | Review of Financial Studies2005，，18： | 1 |
| 11 | Powerful CEOs and Their Impact on Corporate Performance显示文摘 | Adams R B Heitor A Daniel F | 2005 | The Riview of Financial Studies2005，18，4： | 1 |
| 12 | Financial constraints, asset tangibility, and corporate investment 显示文摘 | HEITOR A MURILLO C | 2007 | The Review of Financial Studies2007，20，5： | 1 |
| 13 | The effect of external finance on the equilibrium allocation of capital 显示文摘 | HEITOR A WOLFENZON D | 2005 | Journal of Fi- nancial Economics2005，75，： | 1 |
| 14 | Gravitational effects on the structure and propagation of premixedflame显示文摘 | HAMINS A HEITOR M LIBBY P A | 1988 | Acta Astronautica1988，17，5： | 1 |
| 15 | A reactive role assignment for data routing in event-based wireless sensor networks显示文摘 | Eduardo F Nakamura Heitor S Ramos Leandro A Villas | 2009 | Computer Networks2009，53，12： | 1 |
| 16 | Characteristics of Turbulent Heat Transport in Nonpremixed Jet Flames显示文摘 | Caldeira-Pires A Heitor M V | 2001 | Combustion and Flame2001，124，： | 1 |
| 17 | The effect of external fi- nance on the equilibrium allocation of capital 显示文摘 | HEITOR A WOLFENZON D | 2005 | Journal of Financial Economics2005，75，： | 1 |
| 18 | Characteristics of nitric oxide formation rates in turbulent non-premixed jet flames显示文摘 | Caldeira-Pires A Heitor M V Carvalho J A | 2000 | Combust Flame2000，120，3： | 1 |
| 19 | Experimental characterization of non-premixed turbulent jet propane flames显示文摘 | Caldeira-Pires A Heitor M V | 2000 | Experimental Thermal and Fluid Science2000，23，34： | 1 |
| 20 | Data mining with a ant colony optimization algorithm显示文摘 | Rafael S Parpinelli Heitor S Lopes Alex A Freitas | 2002 | IEEE Trans On Evolution Computing2002，6，4： | 1 |
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