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| 1 | Double balloon endoscopy associated pancreatitis:A description of six cases显示文摘AIM:To perform a single-center analysis of all double balloon endoscopy (DBE) related cases of pancreatitis identified prospectively from a recorded DBE-complication database. METHODS:From November 2003 until January 2007, 603 DBE procedures were performed on 412 patients, with data on complications recorded in a database. The setting was a tertiary care center offering DBE. DBE was performed from the antegrade or retrograde route. Out-come measurements included age, gender, medication, indication, DBE-endoscope type, insertion depth, proce-dure duration, findings, interventions, post-procedural abdominal pain, and post-procedural hospitalization. RESULTS:This is the largest single-center study report-ing on post-DBE pancreatitis prospectively. Six patients (1.0%) developed post-DBE pancreatitis, all after antegrade DBE. There was no association with gender, duration of the procedure or type of endoscope. The mean age was 51.9 years (range 25-78). Four patients had severe pancreatitis. Of these, two had inflammatory signs in the body-tail region, one had pancreatitis in the tail region, and the total pancreas was involved in one. CONCLUSION:The incidence of post-DBE pancreatitis in our series is higher than previously reported. We found no relation with DBE-endoscope type. The inflammatory changes occurred in the body-tail region of the pancreas, suggesting that post-DBE pancreatitis is caused by repetitive mechanical strain on the pancreas. | Soeresh VA Jarbandhan Stijn JB van Weyenberg Willem M van der Veer Dimitri GN Heine Chris JJ Mulder Maarten AJM Jacobs | 2008 | World Journal of Gastroenterology2008，14，5： | 8 |
| 2 | Lrp1 in osteoblasts controls osteoclast activity and protects against osteoporosis by limiting PDGF–RANKL signaling显示文摘Skeletal health relies on architectural integrity and sufficient bone mass, which are maintained through a tightly regulated equilibrium of bone resorption by osteoclasts and bone formation by osteoblasts. Genetic studies have linked the gene coding for low-density lipoprotein receptor-related protein1(Lrp1) to bone traits but whether these associations are based on a causal molecular relationship is unknown. Here, we show that Lrp1 in osteoblasts is a novel regulator of osteoclast activity and bone mass.Mice lacking Lrp1 specifically in the osteoblast lineage displayed normal osteoblast function but severe osteoporosis due to highly increased osteoclast numbers and bone resorption. Osteoblast Lrp1 limited receptor activator of NF-κB ligand(RANKL) expression in vivo and in vitro through attenuation of platelet-derived growth factor(PDGF-BB) signaling. In co-culture, Lrp1-deficient osteoblasts stimulated osteoclastogenesis in a PDGFRβ-dependent manner and in vivo treatment with the PDGFR tyrosine kinase inhibitor imatinib mesylate limited RANKL production and led to complete remission of the osteoporotic phenotype. These results identify osteoblast Lrp1 as a key regulator of osteoblast-to-osteoclast communication and bone mass through a PDGF–RANKL signaling axis in osteoblasts and open perspectives to further explore the potential of PDGF signaling inhibitors in counteracting bone loss as well as to evaluate the importance of functional LRP1 gene variants in the control of bone mass in humans. | Alexander Bartelt Friederike Behler-Janbeck F.Timo Beil Till Koehne Brigitte Müller Tobias Schmidt Markus Heine Laura Ochs Tayfun Yilmaz Martin Dietrich Jan P.Tuckermann Michael Amling Joachim Herz Thorsten Schinke Joerg Heeren Andreas Niemeier | 2018 | Bone Research2018，6，1： | 5 |
| 3 | Could a cervical occlusion suture be effective at improving perinatal outcome? 显示文摘 | Noori M Helmig RB Hein M | 2007 | BJOG2007，114，5： | 1 |
| 4 | EU clean coal technology-co- combustion of coal and biomass显示文摘 | Hein K R G Bemtgen J M | 1998 | Fuel Processing Tech- nology1998，54，： | 1 |
| 5 | Double-balloon enterosco- py:Indications,diagnostic yield,and complications in a series of 275 patients with suspected small-bowel disease显示文摘 | Heine GD Hadithi M Groenen MJ | 2006 | Endoscopy2006，38，1： | 1 |
| 6 | Inactivation ofauxin in tobacco transformed with the indoleacetic acid-lysine synthetase gene of Pseudomonas savastanoi显示文摘 | Romano C P Hein M B Klee H J | | 0，，03： | 1 |
| 7 | Statistical analysis of the effect of magnet placement on cogging torque in fractional pitch permanent magnet motors 显示文摘 | HEINS G BROWN T THIELE M | 2011 | IEEE Transactions on Magnetics2011，47，8： | 1 |
| 8 | Youth athletes'perception of autonomy support from the coach,peer motivational climate and intrinsic motivation in sport setting:Oneyear effects显示文摘 | JESAAR H HEIN V HAGGER M S | 2012 | Psychology of Sport and Exercise2012，，13： | 1 |
| 9 | Fluid inclusion petrogra-phy 显示文摘 | VAN DEN K A M HEIN U F | 2001 | Lithos2001，55，1： | 1 |
| 10 | A capripoxvirus detection PCR and antibody ELISA based on the maior antigen P32, the homolog of the vaccinia virus H3L gene 显示文摘 | Heine H G Stevens M P Foord A J | 1999 | J Immune Meth1999，277，： | 1 |
| 11 | Nutrient limitation of phytoplankton biomass or growth rate- An experimental approach using marine enclosures显示文摘 | HEIN M RIEMANN B | 1995 | Journal of Experimental Marine Biology and Ecology1995，188，2： | 1 |
| 12 | Frankfurt artificial stock market: A microscopic stock market model with heterogeneous interacting agents in small-world communication networks显示文摘 | Hein O Schwind M Spiwoks M | 2008 | Journal of Economic Interaction and Coordination2008，3，1： | 1 |
| 13 | Optimization of stabilization and carbonization treatment of PAN fibres and structural characterization of the resulting carbon fibres显示文摘 | FITER E FROBS W HEINE M | 1986 | Carbon1986，24，4： | 1 |
| 14 | TGFα-associated MUG2 and MUC3 expression of the gastric epithelium in Menetri-er's diseaseduring remission of ulcerative colitis显示文摘 | Zimmer KP Heine M Weissen-Plenz G | 2011 | Gut2011，60，11： | 1 |
| 15 | A prospective study compa- ring video capsule endoscopy with double-balloon enteruscopy in pa- tients with obscure gastrointestinal bleeding 显示文摘 | Hadithi M Heine GD Jacobs MA | 2006 | Am J Gastroenterol2006，101，1： | 1 |
| 16 | P300 Topography and Modality Effects from a Single-Stimulus Paradigm显示文摘 | Polich J M R D Heine | 1996 | Psychophysiology1996，33，6： | 1 |
| 17 | Mechanisms of energy absorption in special devices for use in earthquake resistant structures显示文摘 | Kelly J M Skinner R I Heine A J | 1972 | Bulletin of New Zealand National Society for Earthquake Engineering1972，5，3： | 1 |
| 18 | Automation in coagulation testingc显示文摘 | Reinauer H | 1996 | JIFCC1996，8，： | 1 |
| 19 | Suppressed proliferationand apoptotic changes in the rat dentate gurus after acute andchronic stress are reversible显示文摘 | Heine V M Maslam S Zareno J | 2004 | Eur J Neurosci2004，19，1： | 1 |
| 20 | Genetic variants of IL-13 signalling and human asthma and atorpy显示文摘 | Hein Z mann A Mao XQ Akainua M | 2000 | Hum Mol Genet2000，9，： | 1 |
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