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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Structural equation model for predicting technology commercialization success index(TCSI) 显示文摘 | SOHN S Y HEE T M | 2003 | Technological Forecasting and Social Change2003，70，9： | 1 |
| 3 | Performance evaluation of high modulus asphalt mixtures for long life asphalt pavements显示文摘 | Hynu J L Jung H L Hee M P | 2007 | Construction and Building Materials2007，21，5： | 1 |
| 4 | Optical coherence tomography of central serous chorioretinopathy显示文摘 | Hee M R Gass J D J | 1995 | Am J Ophthalmol1995，120，： | 1 |
| 5 | Exceptional chemical and thermal stability of zeolitic imidazolate frameworks显示文摘 | Sung Park Kyo Ni Zheng Cete Adrien P Choi Jae Yong Huang Rudan Uribe-Romo Femando J Chae Hee K O'Keeffe Michael Yaghi Omar M | 2006 | Proceedings of the National Academy of Sciences2006，103，10： | 1 |
| 6 | Prebiotics and inulin-based fibers exert chronic effects on calcium utilization in a postmenopausal rodent model显示文摘 | Lee Cole L L Hee W L enhance magnesium absorption Berdine M R | 2012 | Journal of Food Science2012，77，4： | 1 |
| 7 | The genus Acipenser as a model system for vertebrate urogenital development: Nephrostomial tubules and their significance for the origin of the gonad显示文摘 | Wrobel H H Hees I Schinnel M | 2002 | Anat Embryol2002，205，： | 1 |
| 8 | Polymorphism of apolipoprotein E and occurrence of dysbeta lipoproteinaemia in man显示文摘 | Utermann G Hees M Steinmetz A | 1997 | Nature1997，269，： | 1 |
| 9 | Reticular synthesis and the design of new materials显示文摘 | Yaghi Omar M O'Keeffe Michael Ockwig Nathan W Chae Hee K Eddaoudi Mohamed Kim Jaheon | 2003 | Nature2003，423，： | 1 |
| 10 | Sr-Nd-Pb isotope and trace element systematics of mantle xenoliths from Late Cenozoic alkaline lavas,South Korea显示文摘 | Sung H C Sung-Tack K Samuel B M Hee S | | 0，，： | 1 |
| 11 | Hemolytic effects of dehydroepiandrosterone in vitro显示文摘 | Hu M L Hee Poh Ng Ming-Kuei Shih | 1997 | Life Science1997，61，21： | 1 |
| 12 | Business process redesign: a Petri-net-based approach显示文摘 | van der Aalst W van Hee K M | 1996 | Computers in Industry1996，29，12： | 1 |
| 13 | A simplified subspace fitting method for estimating shape of a towed array显示文摘 | Hee Y P Ki M K Hyun W K | 2008 | IEEE J Ocean Eng2008，33，2： | 1 |
| 14 | Oscillapeptin, an elastase and chymorypsin inhibitor from the cyanobacterium oscil-latofia 'agardbin (NIES-204)显示文摘 | Hee J Masabiro M HisashiM | 1995 | Tctrahedron Letters1995，36，29： | 1 |
| 15 | Performance evaluation of high modulus asphalt mixtures for long life asphalt pavements显示文摘 | Hynu J L Jung H L Hee M P | 2007 | Construction and building materials2007，21，5： | 1 |
| 16 | Business Process Redesign:A Petri-net-based Approach 显示文摘 | Van Der Aalst W M P Van Hee K M | 1996 | Computers in Industry1996，29，12： | 1 |
| 17 | Optical coherence tomog- raphy of the human retina显示文摘 | Hee M R Huang D Swanson E A | 1995 | Arch Ophthalmol1995，113，： | 1 |
| 18 | Multistage electrodialysis for large - scale separation of racemic mixtures显示文摘 | E M van der Ent P van Hee Keurentjes J T F | 2002 | J Membr Sci2002，204，： | 1 |
| 19 | Hypercapnia attenuates ventilator-induced diaphragm atrophy and modulates dysfunction 显示文摘 | Sehellekens WJ van Hees HW Kox M | 2014 | Crit Care2014，18，1： | 1 |
| 20 | Studies on tumor promoters: the first synthesis of the phorbol skeleton显示文摘 | Paul A Wender Richard M Keenan Hee Yoon Lee | 1987 | J Am Chem Soc1987，109，14： | 1 |
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