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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Current protective strategies in liver surgery显示文摘During liver resection surgery for cancer or liver transplantation,the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow),which results in liver injury [ischemiareperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia,ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response),ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion),pharmacological agents to decrease IR injury,genetic modulation of IR injury,and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC,ischaemic postconditioning,various pharma-cological agents,gene therapy,and machine perfusion decrease IR injury,none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning,gene therapy,and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection. | Kurinchi S Gurusamy Hector D Gonzalez Brian R Davidson | 2010 | World Journal of Gastroenterology2010，16，48： | 7 |
| 3 | Lattice Dynamics, Ther- modynamics and Elastic Properties of Monoclinic Li2 CO3 from Den- sity Functional Theory 显示文摘 | Shang S L Hector L G Shi S Q | 2012 | Acta Mater2012，60，： | 1 |
| 4 | Apoptosis signaling proteins asprognostic biomarkers in colorectal cancer: a review 显示文摘 | HECTOR S PREHN J H | 2009 | Biochim Biophys Acta2009，1795，2： | 1 |
| 5 | New Ap- proach to Gas Pressure Profile Prediction for High Tem- perature AA5083 Sheet Forming 显示文摘 | Jarrar Firas S Hector Jrlouis G Khraisheh | 2010 | Journal of Materials Processing Technology2010，210，67： | 1 |
| 6 | Selective inhibition of the oxidation of ferrous iron or sulfur in Thiobacillusferrooxidans显示文摘 | LESIA H HECTOR M L ISAMU S | 2000 | Applied and Environmental Microbiology2000，66，3： | 1 |
| 7 | X-ray lithography for ≤100 nm ground rules in complex patterns显示文摘 | Pol V Krasnoperova A | 1997 | J Vac Sci Technol B1997，15，： | 1 |
| 8 | Thermoelastic stresses in a bonded layer due to repetitively pulsed laser radiation显示文摘 | Kim W S Hector L G Hetnarski R B | 1997 | Acta Mechanica1997，125，： | 1 |
| 9 | Multiparametric MP,1 a nalysis for the identification of high intensity focused ultrasound treated tumor tissue 显示文摘 | Hectors S J Jacobs I Strijkers G J | 2014 | PLoS One2014，9，99： | 1 |
| 10 | Clinical assessment of heart-type fatty acid binding protein in early diagnosis of acute coronary syndrome显示文摘 | Hector Alonso Valle Luis García-Castrillo Riesgo Miguel Sántalo Bel Francisco Epelde Gonzalo Miguel Sánchez Sanchez Luis Iglesias Oliva | 2008 | European Journal of Emergency Medicine2008，，3： | 1 |
| 11 | Study of staphylococcal toxic shock syndrome toxin in human epithelial cell culture 显示文摘 | VLADIMIR M K MERLIN S B HECTOR S | 1984 | The Journal of Infectious Diseases1984，150，4： | 1 |
| 12 | Prevention and control of cystic echinococcosis显示文摘 | Philip S Craig Donald P McManus Marshall W Lightowlers Jose A Chabalgoity Hector H Garcia Cesar M Gavidia Robert H Gilman Armando E Gonzalez Myriam Lorca Cesar Naquira Alberto Nieto Peter M Schantz | 2007 | The Lancet Infectious Diseases2007，，6： | 1 |
| 13 | Molecular and morphological evidence for threespecies of Diplostomum ( Digenea : Diplostomidae) , parasites of fishes and fish-eat- ing birds in Spain显示文摘 | Perez-del-Olmo A Georgieva S Hector J P 2014 | 2014 | Parasites & Vectors2014，7，： | 1 |
| 14 | Bilateral Breast Carcinoma: Clinical Characteristics and Its Impact on Survival显示文摘 | Hector D.Vuoto Alejandra M.García Gabriela B.Candás Agustina GonzalezZimmermann Juan LuisUriburu Juan A. M.Isetta LucasCogorno MarinaKhoury Oscar L.Bernabó | 2010 | The Breast Journal2010，，6： | 1 |
| 15 | Apoptosis signaling proteins as prognostic biomarkers in colorectal cancer:a review显示文摘 | Hector S Prehn JH | 2009 | Biochim Biophys Acta2009，1795，2： | 1 |
| 16 | Anisotropy and Temperature Dependence of Structural, Thermodynamic, and Elastic Prop- erties of Crystalline CeUulose I-Beta: a First-Principles Investigation 显示文摘 | Dri F L Shang S L Hector L G | 2014 | Modelling Simul Mater Sci Eng2014，22，08： | 1 |
| 17 | Hyperbolic heat conduction due to axisymmetric continuous or pulsed surface sources显示文摘 | Kim W S Hector L G Ozisik M N | 1990 | Journal of Applied Physics1990，68，： | 1 |
| 18 | A Heuristic Method for Parameter Selection in LS- SVM, Application to Time Series Prediction显示文摘 | GINE R S HECTOR P LGNACIO R | 2011 | International Journal of Forecasting2011，27，3： | 1 |
| 19 | Sample preparation focusing on plant proteomics: extraction, e- valuation and identification of proteins from sunflower seeds显示文摘 | Herbert de S B Daiane L Q de S Hector H F K | 2013 | Anal Methods2013，5，1： | 1 |
| 20 | Low temperature H2S dry-desulfurization with zinc oxide 显示文摘 | Hector F G Hugo M G Luis J G Jennifer H Aimee M Steven L S | 2010 | Microporous and Mesoporous Materials2010，127，： | 1 |
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