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| 1 | 重性抑郁症首发未用药患者的枕叶GABA波谱研究显示文摘在中枢神经系统中,γ-氨基丁酸(GABA)是主要的抑制性神经递质。由于GABA在普通磁共振波谱(MRS)上为低谱峰信号,且与其他物质的波峰重叠,因此难以准确得出其在脑内感兴趣区的含量。为观察抑制性神经递质GABA在首发未用药重性抑郁症(MDD)患者枕叶的含量改变,本研究采用了J-耦合编辑点分辨波谱(MEGA-PRESS)技术检测18例首发未用药重性MDD(17项HAMD评分>18分)患者和23名健康对照被试枕叶皮层的GABA含量。采用双样本t检验及相关分析进行统计学处理。结果表明,病例组枕叶GABA含量(11.35±3.26)显著低于对照组(27.30±8.87),P<0.001。病例组枕叶GABA含量与汉密尔顿抑郁量表及贝克抑郁自评量表相关性均不显著。首发未用药重性MDD患者的枕叶GABA含量降低,可能导致其视觉功能下降。 | 宋哲 黄沛钰 邱丽华 吴杞柱 龚启勇 张必达 Heberlein Keith 谢鹏 | 2012 | 生物医学工程学杂志2012，29，2： | 7 |
| 2 | 新一代渴望导管: 在肺的栓塞的处理的可行性显示文摘 AIM: To report our preliminary experience with a new generation aspiration catheter in the treatment of symptomatic pulmonary embolism(PE). METHODS: A retrospective database search for pulmonary artery embolectomy since introduction of the Pronto.035' and XL extraction catheter(Vascular Solutions, Minneapolis, MN) at our institution in 10/2009 was performed. Ten consecutive patients were identified in which the Pronto.035' or XL catheter was used between 01/2010 and 03/2013. All patients were referred for catheter based embolectomy due to contraindications to systemic lysis, or for being in such a critical clinical condition that immediate percutaneous treatment deemed warranted. The computed tomography(CT) right to left heart ratio as predictor for the severity of the PE was retrospectively evaluated on standard axial views. The difference between pre- and post-procedure pulmonary pressure measures was taken to assess the procedural effect.RESULTS: Extensive PE was confirmed angiographically in all patients. Measured right- to left ventricle(RV/LV) ratios were elevated beyond one in seven of the eight available CTs. Acute procedural success defined as clinical removal of visible thrombus and improvement in mean pulmonary artery pressure was seen in all recorded patients(n = 8), the mean pulmonary pressures declined from a median(range) of 35.5(19-46) to 23(10-37, P = 0.008) mmHg. Neither death nor other complications occurred intra- or immediately periprocedural, yet short term mortality within 30 d was found in 6 out of 9 patients, one patient was lost in follow up. The cause of death within 30 d in the 6 patients was identified as: Circulatory failure in direct connection with the PE(n = 2), stroke, sepsis, or succumbing to malignancy in a hospice setting(n = 2). CONCLUSION: Success in thrombus removal with improved pulmonary hypertension and systemic hypotension suggests this aspiration technique to be effective. Aspiration catheters should be part of further trials. | Wolf E Heberlein Mollie E Meek Omar Saleh James C Meek Shelly Y Lensing William C Culp | 2013 | World Journal of Radiology2013，5，11： | 2 |
| 3 | Simulation results of arc behavior in different plasma spray torches显示文摘 | Trelles J P Heberlein J V R | 2006 | J Thermal Spray Technology2006，15，4： | 1 |
| 4 | An Experimental Investigation of Factors Affecting Arc-cathode Erosion显示文摘 | Zhou X Heberlein J | 1998 | Journal of Physics D: Applied Physics1998，31，19： | 1 |
| 5 | Contingent Valuation of En- vironmental Assets: Comparison with a Stimulated Market 显示文摘 | Bishop R C Heberlein T A Kealy M J | 1983 | Nat- ural Resources Journal1983，23，： | 1 |
| 6 | Network intrusion detection 显示文摘 | Heberlein T L Levitt K N | 1994 | IEEE Network1994，8，3： | 1 |
| 7 | Wire-Arc Spray Modeling 显示文摘 | Milind Kelkar Joachim Heberlein | 2002 | Plasma Chemistryand Plasma Processing2002，22，1： | 1 |
| 8 | Network Intrusion Detection显示文摘 | Mukherjee B Heberlein T L Levitt K N | 1994 | IEEE Network1994，8，3： | 1 |
| 9 | Patient safety surveyreport 显示文摘 | Manno M Hogan P Heberlein V | 2006 | Nursing2006，36，5： | 1 |
| 10 | Wire-arc spray modeling显示文摘 | Milind Kelkar Joachim Heberlein | 2002 | Plasma Chemistry and Plasma Rocessing2002，22，： | 1 |
| 11 | Theoretical-study of factors influencing arc erosion of cathode显示文摘 | Zhou X Heberlein J Pfender E | 1994 | IEEE Transactions on Components Packaging and Manufacturing Technology Part A1994，17，1： | 1 |
| 12 | Measuring values of extra-market goods:Are indirect methods biased显示文摘 | Bishop R C Heberlein T A | | 0，，03： | 1 |
| 13 | Network Intrusion Detection显示文摘 | MU KHERJEE B HEBERLEIN L T LEVITT K N | 1994 | IEEE Network1994，8，3： | 1 |
| 14 | Network Intrusion Detection显示文摘 | Mukherjee B Heberlein L T Leivitt K N | 1994 | IEEE Network1994，8，3： | 1 |
| 15 | Measuring values of extra market goods:Are indirect methods biased显示文摘 | Bishop R C Heberlein T A | 1981 | American Journal of Agricultural Economics1981，66，3： | 1 |
| 16 | Network intrusion detection显示文摘 | Mukherjee B Heberlein T L Levitt K N | 1994 | IEEE network1994，8，3： | 1 |
| 17 | Arc instabilities in a plasma spray torch显示文摘 | Duan Z Heberlein J J | 2002 | Journal of Thermal Spray Technology2002，1，1： | 1 |
| 18 | Tumor cells escape suicide gene therapy by genetic and epigenetic instability 显示文摘 | Frank O Rudolph C Heberlein C | 2004 | Blood2004，104，12： | 1 |
| 19 | Atomization and particle-jet interactions in the wire-are spraying process 显示文摘 | HUSSARY N A HEBERLEIN J V R | 2001 | Journal of Thermal Spray Technology2001，10，4： | 1 |
| 20 | Network Intrusion Detection 显示文摘 | B Mukherjee L T Heberlein Levitt | 2004 | IEEE Network2004，8，3： | 1 |
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