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1篇 您的检索式:作者名="Heather HARTIG"
    题名 作者 年代 出处 被引量
1The role of apoptosis in the development and function of T lymphocytes显示文摘Apoptosis plays an essential role in T cell biology. Thymocytes expressing nonfunctional or autoreactive TCRs are eliminated by apoptosis during development. Apoptosis also leads to the deletion of expanded effector T cells during immune responses. The dysregulation of apoptosis in the immune system results in autoimmunity, tumorogenesis and immunodeficiency. Two major pathways lead to apoptosis: the intrinsic cell death pathway controlled by Bcl-2 family members and the extrinsic cell death pathway controlled by death receptor signaling. These two pathways work to- gether to regulate T lymphocyte development and function.Heather HARTIG Ivan DZHAGALOV David DRAPER 2005Cell Research2005,15,10:16
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