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| 1 | Interferon-c and interleukin-4 detected in serum and saliva from patients with oral lichen planus显示文摘Our previous salivary study had demonstrated an apparent T helper 2(Th2)-predominance in saliva of oral lichen planus(OLP) patients and suggested a potential of salivary interleukin-4(IL-4) as a biomarker for monitoring disease severity. To further determine the consistency of Th1/Th2 bias of OLP, this study investigated the expression profile of interferon-c(IFN-c) and IL-4 in serum and the relationship of the serum levels of these cytokines with their saliva partners. Sixty ethnic Chinese patients with OLP(40 of the erythematous/ulcerative form and 20 of the reticular form) were recruited for this study, with 40 age–sex-matched healthy volunteers as control group. IFN-c and IL-4 levels in serum and paired saliva samples were screened by enzyme-linked immunosorbent assay. OLP patient showed a low-level IFN-c but high-level IL-4 expression profile in both serum and saliva, with a lower IFN-c/IL-4 ratio. Serum IL-4 level in the erythematous/ulcerative group was significantly higher than that in the reticular group. Serum levels of IFN-c and IL-4 were significantly and positively correlated with their saliva partners. These results provided more evidence for Th2 cytokinepredominant immune imbalance in OLP, as well as the potential of IL-4 as the biomarker for monitoring severity of OLP. | Wen-Zhao Liu Ming-Jing He Long Long Dong-Liang Mu Ming-Shu Xu Xue Xing Xin Zeng Ga Liao Hong-Xia Dan Qian-Ming Chen | 2014 | International Journal of Oral Science2014，6，1： | 10 |
| 2 | Magnetic nanoparticles based cancer therapy: current status and applications显示文摘Nanotechnology holds a promising potential for developing biomedical nanoplatforms in cancer therapy. The magnetic nanoparticles, which integrate uniquely appealing features of magnetic manipulation, nanoscale heat generator, localized magnetic field and enzyme-mimics, prompt the development and application of magnetic nanoparticles-based cancer medicine. Considerable success has been achieved in improving the magnetic resonance imaging(MRI) sensitivity, and the therapeutic function of the magnetic nanoparticles should be given adequate attention. This work reviews the current status and applications of magnetic nanoparticles based cancer therapy. The advantages of magnetic nanoparticles that may contribute to improved therapeutics efficacy of clinic cancer treatment are highlighted here. | Huan Zhang Xiao Li Liu Yi Fan Zhang Fei Gao Ga Long Li Yuan He Ming Li Peng Hai Ming Fan | 2018 | Science China(Life Sciences)2018，61，4： | 8 |
| 3 | Effect of longer term modest salt reduction on blood pressure: cochrane systematic review and met-analysis of randomised trials显示文摘 | He FJ Li J Macgregor GA | 2013 | BMJ2013，346，： | 1 |
| 4 | Resistance to thyroid hormone显示文摘 | Carvalho GA Ramos HE | 2004 | Arq Bras Endocrinot Metabol2004，48，1： | 1 |
| 5 | Effect of sodium intake on ability of human plasma to inhibit renal Na+ -K+ -adenosis triphosphatase in vitro显示文摘 | De Wardener HE MacGregor GA Clarkson EM Alahgband-Zadeh Bitensky L Chayen J | 1981 | Lancet1981，21，： | 1 |
| 6 | Effect of sodium intake on ability of human plasma to inhibit renal Na^+-K^+-adenosine triphosphatase in vitro显示文摘 | De Wardener HE MacGregor GA Clarkson EM | 1981 | Lancet1981，1，8217： | 1 |
| 7 | Immature rat ovaries become revascularized rapidly after autotransplantation and show a gonadotropin-dependent increase in angiogenic factor gene expression显示文摘 | Dissen GA Lara HE Fahrenbach WH | 1994 | Endocrinology1994，134，3： | 1 |
| 8 | Can a low-sodium, high-potassium salt substitute reduce blood pressure in rural Chinese people 显示文摘 | He FJ Macgregor GA | 2008 | Nat Clin Praet Cardinvase Med2008，5，4： | 1 |
| 9 | A role for tryptase in the activation of human mast cells:modulation of histamine release by tryptase and inhibitors of tryptase 显示文摘 | He S Ga(G)a MD Walls AF | 1998 | J Pharmacol Exp Ther1998，286，1： | 1 |
| 10 | Tolerance and diagnostic accuracy of an abbreviated adenosine infusion for myocardial scintigraphy:a randomized,prospective study显示文摘 | Treuth MG Reyes GA He ZX | 2001 | J Nucl Cardiol2001，8，5： | 1 |
| 11 | Hypoxia leads to Na, K-ATPase downregulation via Ca ( 2 + ) release-activated Ca (2 + ) channels and AMPK activation 显示文摘 | Gusarova GA Trejo HE Dada LA | 2011 | Mol Cell Biol2011，31，17： | 1 |
| 12 | Immature rat ovaries become revascularized rapidly after autotransplanta-tion and show a gonadotropin-dependent increase in angio- genic factor gene expression 显示文摘 | Dissen GA Lara HE Fahrenbach WH | 1994 | Endocrinology1994，134，： | 1 |
| 13 | Hematopoietic stem celltransplantation for refractory or recurrent non-Hodgkin lymphoma inchildren and adolescents显示文摘 | Gross TG Hale GA He W | 2010 | Biol Blood Marrow Transplant2010，16，2： | 1 |
| 14 | Can a low-sodium, high-potassium salt substi- tute reduce blood pressure in rural Chinese people 显示文摘 | He FJ Macgregor GA | 2008 | Nat Clin Pract Cardiovase Med2008，5，4： | 1 |
| 15 | Mutational analyses of human eIF5A-1-identification of amino acid residues critical for eIF5A activity and hypusine modification显示文摘 | Cano VS Jeon GA Johansson HE | 2008 | FEBS J2008，275，1： | 1 |
| 16 | Systematic review of combined angiotensin-converting enzyme in hibition and angiotensin receptor blockade in hypertension显示文摘 | Doulton TW He F J MacGregor GA | 2005 | Hypertension2005，45，5： | 1 |
| 17 | Hematopoietic stem cell transplantation for refractory or recurrent non-Hodgkin lymphoma in children and adolescents显示文摘 | Gross TG Hale GA He W | | 0，，02： | 1 |
| 18 | p53 and bc1-2 in epithelial ovarian carcinoma:their value as prognostic indicators at a median follow-up of 60 months显示文摘 | Geisler JP Geisler HE Miller GA | 2000 | Gynecol Oncol2000，77，： | 1 |
| 19 | Salt,blood pressure and cardiovascular disease显示文摘 | He FJ MacGregor GA | | 0，，4： | 1 |
| 20 | Chlamydial infection in vitamin D receptor knockout mice is more intense and prolonged than in wild-type mice显示文摘 | He Q Ananaba GA Patrickson J | 2013 | Steroid Biochem Mol Biol2013，135，14： | 1 |
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