|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth显示文摘AIM: To investigate the functional significance of insulin-like growth factor binding protein-5 (IGFBP-5) overexpression in pancreatic cancer (PaC).METHODS: The effects of IGFBP-5 on cell growth were assessed by stable transfection of BxPC-3 and PANC-1 cell lines and measuring cell number and DNA synthesis. Alterations in the cell cycle were assessed by flow cytometry and immunoblot analyses. Changes in cell survival and signal transduction were evaluated after mitogen activated protein kinase and phosphatidylinositol 3-kinase (PI3K) inhibitor treatment.RESULTS: After serum deprivation, IGFBP-5 expression increased both cell number and DNA synthesis in BxPC-3 cells, but reduced cell number in PANC-1 cells. Consistent with this observation, cell cycle analysis of IGFBP-5-expressing cells revealed accelerated cell cycle progression in BxPC-3 and G2/M arrest of PANC-1 cells. Signal transduction analysis revealed that Akt activation was increased in BxPC-3, but reduced in PANC-1 cells that express IGFBP-5. Inhibition of PI3K with LY294002 suppressed extracellular signal-regulated kinase-1 and -2 (ERK1/2) activation in BxPC-3, but enhanced ERK1/2 activation in PANC-1 cells that express IGFBP-5. When MEK1/2 was blocked, Akt activation remained elevated in IGFBP-5 expressing PaC cells; however, inhibition of PI3K or MEK1/2 abrogated IGFBP-5-mediated cell survival.CONCLUSION: These results indicate that IGFBP-5 expression affects the cell cycle and survival signal pathways and thus it may be an important mediator of PaC cell growth. | Sarah K Johnson Randy S Haun | 2009 | World Journal of Gastroenterology2009，15，27： | 5 |
| 2 | Thermodynamic theory of the lead Zirconate-Titanate solid solution system, Part V: theoretical caculations显示文摘 | HAUN M J FURMAN E JANG S J | 1989 | Ferroelectrics1989，99，1： | 2 |
| 3 | Pacemaker implantation in a patient with brugada and sick sinus syndrome显示文摘Brugada syndrome (BrS) is a rare and inherited primary arrhythmic syndrome characterized by ST-segment elevations in the right precordial leads (V1 -V3 ) with an increased risk of sudden cardiac death (SCD). Arrhythmias in BrS are often nocturne, and brady-arrhythmias are often seen in patients with loss-of-function mutations in SCN5A . In this case-report we present a 75-year old woman referred to our outpatient clinic for inherited cardiac diseases for a familial clinical work-up. Since childhood she had suffered from dizziness, absence seizures, and countless Syncope's. In 2004 sick sinus syndrome was suspected and she wastreated with implantation of a pacemaker (PM) at another institution. An inherited cardiac disease was one day suddenly suspected, as the patient had a 61-year old brother who was diagnosed with symptomatic BrS, and treated with an implantable cardioverter defibrillator (ICD) after aborted SCD. A mutation screening revealed a SCN5A [S231CfsX251 (c.692-693delCA )] loss-of-function mutation not previously reported, and as a part of the cascade screening in relatives she was therefore referred to our clinic. In the 7 year period after PM implantation she had experienced no cardiac symptoms, although her electrocardiogram changes now were consistent with a BrS type 1 pattern. A genetic test confirmed that she had the same mutation in SCN5A as her brother. In this case-report we present a loss-of function mutation in SCN5A not previously associated with BrS nor presented in healthy controls. Sinus node dysfunction has previously been documented in patients with symptomatic BrS, which suggests it is not a rare concomitant. The only accepted treatment of BrS is today implantation of an ICD. In the future studies should evaluate if PM in some cases of symptomatic BrS can be used instead of ICDs in patients with a loss-of-function SCN5A | Bjarke Risgaard Henning Bundgaard Reza Jabbari Stig HaunsФ Bo Gregers Winkel Jacob Tfelt-Hansen | 2013 | World Journal of Cardiology2013，5，3： | 1 |
| 4 | The value of limited computed tomography with rectal contrast in the diagnosis of acute appendicitis 显示文摘 | Susan Walker Willian Haun Jeffrey Clark | 2000 | The American Journal of Surgery2000，180，6： | 1 |
| 5 | Altered lipid metabolism in the presence and absence of extracellular Ca2 + during combined oxygen-glucose deprivation in primary astrocyte cultures 显示文摘 | Haun SE Rosenberger TA | 1995 | J Neurosci R es1995，42，1： | 1 |
| 6 | Mammaglobin gene expression: a superior marker of breast cancer cells in peripheral blood in comparison to epidermal-growth-faclor receptor and cytokeratin-19 显示文摘 | Granewald K Haun M Urbanek M | 2000 | Lab Invest2000，80，7： | 1 |
| 7 | Inosine mediates the proteetive effect of adenosine in rat astrocyte culture subjected to combined glucoseoxygen deprivation显示文摘 | Haun SE Segeleen JE Trapp VL | 1996 | J Neurochem1996，67，5： | 1 |
| 8 | Proteolytic action of kal- likrein-related peptidase 7 produces unique active matrix metallo- proteinase-9 lacking the C-terminal hemopexin domains 显示文摘 | Ramani VC Kaushal GP Haun RS | 2011 | Bio- ehim Biophys Aeta2011，1813，8： | 1 |
| 9 | Inguinal hernia repair: results an open preperitoneal approach显示文摘 | Fenoglio ME Bemas HR Haun WE | 2005 | Hernia2005，9，2： | 1 |
| 10 | A Phenomenological Theory for Phase Transitions Perovskite Ferroelectrics With Oxygen Octahedron Tilts 显示文摘 | Halemane T R Haun M J Cross L E | 1985 | Ferroelectrics1985，62，： | 1 |
| 11 | Comparative Literature in An Age of Terrorism 显示文摘 | Haun Saussy | 2006 | Baltimore: Johns Hopkins University Press2006，，： | 1 |
| 12 | Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice显示文摘 | Cancalon PF Barros SM Haun C | 2011 | J Food Sci2011，76，4： | 1 |
| 13 | Virtual instrumentation applied to monitoring of nuclear reactor refuel process 显示文摘 | Hurd Greg L Haun Melvin C | 1998 | Laboratory Robotics and Automation (S1098-2728)1998，10，2： | 1 |
| 14 | Mammaglobin gene expression: a superior marker of breast cancer cells in periph- eral blood in comparison to epidermal-growth-factor receptor and cytokeratin-19显示文摘 | Grunewald K Haun M Urbanek M | 2000 | Lab Invest2000，80，7： | 1 |
| 15 | Thermodynamic Theory of the Lead Zirconate-titanate Solid Solution System, Part Ⅳ : Tilting of the Oxygen Octahedral 显示文摘 | Haun M J UrmanE F Halemane T R | 1989 | Ferroelectrics1989，99，： | 1 |
| 16 | An atomic frequency standard显示文摘 | Zacharias J Yates G Haun R | 1955 | Proc IRE1955，43，： | 1 |
| 17 | Thermodynamic Theory of the Lead Zirconate-titanate Solid Solution System, Part I : Phenomenology 显示文摘 | Haun M J Furman E Jang S J | 1989 | Ferroelectrics1989，99，： | 1 |
| 18 | Visual quantification of wheat development显示文摘 | HAUN J R | 1973 | A- gronomy Journal1973，65，1： | 1 |
| 19 | Mammaglobin gene expression:a superior marker of breast cances cells in peripheral blood in comparison to epidermal growth factor receptor and cytokeratin-19显示文摘 | Grünewald K Haun M Urbanek M | 2000 | Lab Invest2000，80，7： | 1 |
| 20 | Inosine mediates the protective effect of adenosine in rat astrocyte cultures subjected to combined glucose-oxygen deprivation显示文摘 | Segeleon JE Trapp VL | 1996 | J Neurochem1996，67，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员