|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Overexpression of TLR3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma显示文摘AIM: To investigate the expression of Toll-like receptor (TLR) 3, TLR4, TLR7 and TLR9 in esophageal squamous cell carcinoma (ESCC). METHODS: Reverse transcription-polymerase chain reaction and immunohistochemistry were used to analyze the expression of TLR3, TLR4, TLR7 and TLR9 mRNA and protein in samples from 87 esophageal cancer patients consisting of both tumor and normal tissue. RESULTS: A significant increase in TLR3, TLR4, TLR7 and TLR9 mRNA levels was detected in ESCC samples. Tumors exhibited high TLR protein expression, (70.1%, 72.4%, 66.7% and 78.2% for TLR3, TLR4, TLR7 and TLR9, respectively, P < 0.05). Nevertheless, a significant percentage of tumors also exhibited TLR4 expression in mononuclear inflammatory cells (48.3%) and TLR9 expression in fibroblast-like cells (60.9%). Tumors with high TLR3 expression in tumor cells or high TLR4 expression in mononuclear inflammatory cells were significantly associated with a higher probability of lymph node metastasis and increased depth of invasion. However, tumors with high TLR9 expression in fibroblast-like cells were associated with low probabilities of invasion and metastasis. There was no significant variation between the expression of TLR3, TLR4, TLR7 and TLR9 among different ethnic groups. CONCLUSION: TLR3, TLR4, TLR7 and TLR9 expression appears important to the biological pathogenesis of ESCC. TLRs may represent therapeutic targets for ESCC. | Ilyar Sheyhidin Gulnaz Nabi Ayshamgul Hasim Rui-Ping Zhang Julaiti Ainiwaer Hong Ma Hua Wang | 2011 | World Journal of Gastroenterology2011，17，32： | 22 |
| 2 | Association of defective HLA-Ⅰ expression with antigen processing machinery and their association with clinicopathological characteristics in Kazak patients with esophageal cancer显示文摘背景它被证实了分子能贡献的人的白血球抗原班(HLA-) 的那个有缺点的表达式在癌症的一些类型的癌症房间的有免疫力的避免。这研究的目的是在高风险人乳头状瘤病毒( HPV )在食道的有鳞的房间癌( ESCC )和他们的角色检验 HLA 班抗原和处理抗原的机械( APM )部件的表示感染,并且 50 修理福尔马林的、嵌入石蜡的 ESCC 损害的一个总数从 Xinjiang 医药大学的首先隶属于的医院被收集在 Kazak 种族 group.Methods 与组织病理学说的特征分析他们的协会,中国。HLA- 抗原和 APM 部件的表示层次被 immunohistochemistry 决定;HPV DNA 用聚合酶链反应(PCR ) 被检测下面规定的高频率或 HLA 和 APM 部件的表示的损失在 Kazak 人在食道的癌症被发现的 .Results。HLA- , TAP1, CNX, LMP7, Erp57, Tapasin 和 ERAP1 在 68%,44% 是下面调整的, 48% ESCC, 40% , 52% , 32% 和 20% 损害然后分别地。HLA- 抗原的表示的损失显著地与 APM 部件的部分被相关并且断然与高风险 HPV16 感染相关。 TAP1 , CNX , LMP7 , Erp57 和 Tapasin 损失显著地与肿瘤分级,淋巴节点转移和侵略( P0.05 )的深度被联系我们的结果建议的 .Conclusion APM 部件背叛,这是在 ESCC 损害位于HLA-抗原下面规定下面的机制,并且显示HLA-和 APM 部件的损失表示将成为 ESCC 的一个重要标记和HLA-和 APM 部件表示的分析能从 Kazak eth 为病人向有用预示的信息提供 | Ayshamgul Hasim MA Hong Ilyar Sheyhidin ZHANG Li-wei Abulizi Abudula | 2011 | Chinese Medical Journal2011，，3： | 12 |
| 3 | Plasma free amino acid profiling of esophageal cancer using high-performance liquid chromatography spectroscopy显示文摘AIM:To perform plasma free amino acid(PFAA)profiling of esophageal squamous cell carcinoma(ESCC)patients at different pathological stages and healthy subjects.METHODS:Plasma samples from ESCC patients(n=51)and healthy control adults(n=60)were analyzed by high-performance liquid chromatography(HPLC).The ESCC patients included moderate/poorly-differentiation(n=24),lymph node metastasis(n=17)and clinical stage>Ib2(n=36).Partial least squares discriminant analysis was performed to demonstrate that the PFAA metabolic patterns enabled discrimination between ESCC patients and controls,and the Student t test was applied to assess significant differences in PFAA concentrations between the two groups.RESULTS:There were significant differences in the PFAA profiles between controls and ESCC patients.Compared with healthy controls,the levels of Asp,Glu,Gly,His,Thr,Tau,Ala,Met,Ile,Leu,and Phe were decreased in ESCC patients,but Cys was increased.There exists a strong correlation between PFAA profiles and clinicopathological characteristics in ESCC patients.The levels of many PFAAs(i.e.,Glu,Asp,Ser,Gly,Tau,Ala,Tyr,Val,Ile,and Leu)were related to pathological grading,lymph node metastasis,and ESCC clinical stage.Very good discrimination between ESCC patients and control subjects was achieved by multivariate modeling of plasma profiles.CONCLUSION:HPLC-based plasma profiling analysis was shown to be an effective approach to differentiate between ESCC patients and controls.PFAA profiles may have potential value for screening or diagnosing ESCC. | Hong Ma Ayshamgul Hasim Batur Mamtimin Bin Kong Hai-Ping Zhang Ilyar Sheyhidin | 2014 | World Journal of Gastroenterology2014，20，26： | 11 |
| 4 | Decreased blood riboflavin levels are correlated with defective expression of RFT2 gene in gastric cancer显示文摘AIM:To investigate the relationship between blood riboflavin levels and riboflavin transporter 2(RFT2) gene expression in gastric carcinoma(GC) development.METHODS:High-performance liquid chromatography was used to detect blood riboflavin levels in patients with GC.Real-time fluorogenic quantitative polymerase chain reaction and immunohistochemistry were used to analyze the expression of RFT2 mRNA and protein in samples from 60 GC patients consisting of both tumor and normal tissue.RESULTS:A significant decrease in the RFT2 mRNA levels was detected in GC samples compared with those in the normal mucous membrane(0.398 ± 0.149 vs 1.479 ± 0.587;P = 0.040).Tumors exhibited low RFT2 protein expression(75%,16.7%,8.3% and 0% for no RFT2 staining,weak staining,medium staining and strong staining,respectively),which was significantly lower than that in the normal mucous membrane(10%,16.7%,26.7% and 46.7% for no RFT2 staining,weak staining,medium staining and strong staining,respectively;P < 0.05).Tumors with low RFT2 expression were significantly associated with tumor stage and histological grade.Moreover,a significantly decrease in Uyghur patients was observed compared with Han patients.However,other parameters-gender,tumor location and lymph node metastasis-showed no significant relationship with RFT2 expression.Blood riboflavin levels were reverse correlated with development of GC(1.2000 ± 0.97 569 ng/mL in high tumor stage patients vs 2.5980 ± 1.31 129 ng/mL in low tumor stage patients;P < 0.05).A positive correlation of plasma riboflavin levels with defective expression of RFT2 protein was found in GC patients(2 = 2.619;P = 0.019).CONCLUSION:Defective expression of RFT2 is associated with the development of GC and this may represent a mechanism underlying the decreased plasma riboflavin levels in GC. | Maynur Eli De-Sheng Li Wei-Wei Zhang Bing Kong Chen-Song Du Maimaitiaili Wumar Batur Mamtimin Ilyar Sheyhidin Ayshamgul Hasim | 2012 | World Journal of Gastroenterology2012，18，24： | 6 |
| 5 | Endoscopic therapy for biliary strictures complicating living donor liver transplantation: Factors predicting better outcome显示文摘AIM To identify factors predicting outcome of endoscopic therapy in bile duct strictures(BDS) post living donor liver transplantation(LDLT).METHODS Patients referred with BDS post LDLT, were retrospectively studied. Patient demographics, symptoms(Pruritus, Jaundice, cholangitis), intra-op variables(cold ischemia time, blood transfusions, number of ducts used, etc.), peri-op complications [hepatic artery thrombosis(HAT), bile leak, infections], stricture morphology(length, donor and recipient duct diameters) and relevant laboratory data both pre-and post-endotherapy were studied. Favourable response to endotherapy was defined as symptomatic relief with > 80% reduction in total bilirubin/serum gamma glutamyl transferase. Statistical analysis was performed using SPSS 20.0.RESULTS Forty-one patients were included(age: 8-63 years). All had right lobe LDLT with duct-to-duct anastomosis. Twenty patients(48.7%) had favourable response to endotherapy. Patients with single duct anastomosis, aggressive stent therapy(multiple endoscopic retrogradecholagiography, upsizing of stents, dilatation and longer duration of stents) and an initial favourable response to endotherapy were independent predictors of good outcome(P < 0.05). Older donor age, HAT, multiple ductal anastomosis and persistent bile leak(> 4 wk post LT) were found to be significant predictors of poor response on multivariate analysis(P < 0.05). CONCLUSION Endoscopic therapy with aggressive stent therapy especially in patients with single duct-to-duct anastomosis was associated with a better outcome. Multiple ductal anastomosis, older donor age, shorter duration of stent therapy, early bile leak and HAT were predictors of poor outcome with endotherapy in these patients. | Harshavardhan B Rao Hasim Ahamed Suprabha Panicker Surendran Sudhindran Rama P Venu | 2017 | World Journal of Gastrointestinal Pathophysiology2017，8，2： | 3 |
| 6 | Prolonged survival with confirmed metastatic pulmonary ameloblastoma显示文摘 | Hasim FW Poon CC Smith AC | 2007 | IntJ Oral Maxillofac Surg2007，36，10： | 1 |
| 7 | Natural antioxidant extract from galangal(Alpinia galanga)for minced beef显示文摘 | CHEAH P B HASIM N H A | 2000 | Journal of The Science of Food And Agriculture2000，80，： | 1 |
| 8 | Association of the plasma riboflavin levels and riboflavin transporter (C20orf54) gene statuses in Kazak esophageal squamous cell carcinoma pa- tients显示文摘 | Ainiwaer J Tuerhong A Hasim A | 2013 | Mol Biol Rep2013，40，5： | 1 |
| 9 | Effect of load and speed on the wear behavior of woven glass cloth and aramid fiber-reinforced composites 显示文摘 | Hasim P Nihat T | 2002 | Wear2002，252，11： | 1 |
| 10 | Effect of load and speed on the wear behaviour of woven glass cloth and aramid fiber-reinforced com- posites 显示文摘 | Hasim Pihtili Nihat Tosum | 2002 | Wear2002，252，： | 1 |
| 11 | Long-term application of biomass and reduced use of chemicals alleviate soil compaction and improve soil quality显示文摘 | SERGIO KENJI HOMMAA HASIME TOKESHI LUCAS WILLIAMMENDES | 2012 | Soil&Tillage Research2012，120，： | 1 |
| 12 | Prevalence of falls inelderly men with diabetes in Diabetic Clinic Universiti SainsMalaysia Hospital,Malaysia 显示文摘 | Azidah Abdul Kadir Hasniza Hasim | 2011 | Journal of Men ys Health2011，8，1： | 1 |
| 13 | Metabonomic signature analysis of cervical carcinoma and precancerous lesions in women by 1H NMR spectroscopy显示文摘 | Hasim A Ali M Mamtimin B | | 0，，06： | 1 |
| 14 | Effect of load and speed on the wear behaviour of woven glass cloth and aramid fiber-reinforced composites显示文摘 | Hasim Pihtili Nihat Tosum | 2002 | Wear2002，252，： | 1 |
| 15 | Effect of load and speed on the wear behavior of woven glass fabrics and aramid fibre-reinforced composites显示文摘 | Hasim P Nihat T | 2002 | Wear2002，252，： | 1 |
| 16 | Natural antioxidant extract from galangal (Alpinia galanga) for minced beef 显示文摘 | Cheah P B Hasim N H A | 2000 | J Sci FoodAgric2000，80，10： | 1 |
| 17 | Activity andtoxicity of famesol towards Candida albicans are depen-dent on growth conditions 显示文摘 | Langford ML Hasim S Nickerson KW | 2010 | Antimicrob AgentsChemother2010，54，2： | 1 |
| 18 | Activity and toxicity of farnesol towards Candida albicans are dependent on growth conditions 显示文摘 | LANGFORD M L HASIM S NICKERSON K W | 2010 | Antimierob Agents Chemother2010，54，2： | 1 |
| 19 | Natural antioxidant extract from galangal(Alpinia galangal) for minced beef显示文摘 | Poh Bee Cheah Noor Huda Abu Hasim | 2000 | J Sci Food Agrie2000，80，： | 1 |
| 20 | Association of the plasma andtissue riboflavin levels with C20or?54 expression in cervical lesionsand its relationship to HPY16 infection显示文摘 | Aili A Hasim A Kelimu A | 2013 | PLoS One2013，8，79： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员