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| 1 | Long-term irritable bowel syndrome symptom control with reintroduction of selected FODMAPs显示文摘AIM To investigate the long-term effect of dietary education on a low fermentable oligosaccharide, disaccharide and polyol(FODMAP) diet on irritable bowel syndrome(IBS) symptoms and quality of life(Qo L).METHODS Participants with IBS(Rome III) were randomized to two groups. Group I commenced a low FODMAP diet at baseline. At three months, group II, so far a comparator group, crossed over to a low FODMAP diet while group I started re-challenging foods. All patients completed the IBS SSS(IBS symptom severity scoring system, 0-500 points increasing with severity), IBS Qo L questionnaire(0-100 increasing with Qo L), a FODMAP specific food frequency questionnaire and provided a stool sample at baseline, three and six months for microbiome analysis.RESULTS Fifty participants were enrolled into group I(n = 23) or group II(n = 27). Participants in both groups were similar in baseline values but with more men in group I. There was a significantly lower IBS SSS(275.6 ± 63.6 to 128.8 ± 82.5 vs 246.8 ± 71.1 to 203.6 ± 70.1)(P < 0.0002) and increased Qo L(68.5 ± 18.0 to 83 ± 13.4 vs 72.9 ± 12.8 to 73.3 ± 14.4)(P < 0.0001) in group I vs group II at 3 mo. The reduced IBS SSS was sustained at 6 mo in group I(160 ± 102) and replicated in group II(124 ± 76). Fiber intake decreased on the low FODMAP diet(33 ± 17 g/d to 21 ± 8 g/d)(P < 0.01) and after re-introducing FODMAP containing foods increased again to 27 ± 9 g/d. There was no change seen in the intestinal microbiome when participants adopted a low FODMAP diet.CONCLUSION This study demonstrated that a reduction in FODMAPs improves symptoms in IBS and this improvement can be maintained while reintroducing FODMAPs. | Ruth M Harvie Alexandra W Chisholm Jordan E Bisanz Jeremy P Burton Peter Herbison Kim Schultz Michael Schultz | 2017 | World Journal of Gastroenterology2017，23，25： | 5 |
| 2 | Increased MRP expression is associated with resistance to radiation,anthracyclines and etoposide in cells treated with fractionated γ -radiation显示文摘 | Rozelle M Harvie Mary W Davey Ross A Davey | 1997 | Int J Cancer1997，73，： | 1 |
| 3 | A parametric study of droplet deformation through a microfluidic contraction: Low viscosity Newtonian droplets 显示文摘 | HARVIE D J E DAVIDSON M R COOPER WHITE J J | 2006 | Chemical Engineering Science2006，61，51： | 1 |
| 4 | The Correspondence of Patient Saris- faction and Nurse Burnout显示文摘 | Leiter MP Harvie P Frizzell C | 1998 | Soc Sci Med1998，47，10： | 1 |
| 5 | The Bristol regional pelvic and ac- etabular fracture service:workload implications of managing the polytraumatised patient 显示文摘 | Harvie P Chesser TJ Ward AJ | 2008 | Injury2008，39，8： | 1 |
| 6 | Mineral equilibria in a six- component seawater system Na-K-Mg-Ca-SO4-C1-H20 at 25 ℃ 显示文摘 | HARVIE C E WEARE J H | 1980 | Geochim Cosmochim Acta1980，44，9： | 1 |
| 7 | The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers : a randomized trial in young overweight women 显示文摘 | Harvie MN Pegington M Mattson MP | 2010 | Int J Obes2010，35，： | 1 |
| 8 | Immunoaffinity separation of plasma proteins by IgY microbeads: meeting the needs of proteomic sample preparation and analysis显示文摘 | Huang L Harvie G Feitelson JS | 2005 | Proteomics2005，5，： | 1 |
| 9 | A computational fluid dynamics study of wood fire extinguishment by water sprinkler 显示文摘 | NOVOZHILOV V HARVIE D J E KENT H | 1997 | Fire Safety Journal1997，29，： | 1 |
| 10 | High blood neu- trophil-to-lymphocyte ratio is an indicator of poor prog- nosis in malignant mesothelioma patients undergoing systemic therapy显示文摘 | Kao S C Pavlakis N Harvie R | 2010 | Clin Cancer Res2010，16，23： | 1 |
| 11 | A computational fluid dynamics study of wood fire extinguishment by water sprinkler显示文摘 | NOVOZHILOV V HARVIE D J E KENT J H | 1997 | Fire Safety Journal1997，29，： | 1 |
| 12 | The predic- natural waters : the Na-K- Mg-Ca-H-C1-SO4-OH-HCO3-CO3-C02-H20 system to high ionic strengths at 25 ℃ 显示文摘 | HARVIE C E MOLLER N tion of mineral solubilities in WEARE J H | 1984 | Geochimica et Cosmo- chimica Acta1984，48，4： | 1 |
| 13 | World-of-mouth Processes within a Services Purchase Decision Context显示文摘 | Bansal Voyer Harvis S | | 0，，02： | 1 |
| 14 | Energy balance adiposity and breast cancer-energy restriction strategies for breast cancer prevention显示文摘 | Harvie M Howell A | 2006 | Obes Rev2006，7，1： | 1 |
| 15 | Vaccination to protect against infection of the female reproductive tract显示文摘 | Huston W M Harvie M Mittal A | 2012 | Expert Rev Clin Immunol2012，8，1： | 1 |
| 16 | The steady state current and transference number measurements in polymer electrolytes显示文摘 | Cameron G G Harvie J L Ingram M D | 1989 | Solid State Ionics1989，34，12： | 1 |
| 17 | Burnout among mental health workers: a review and a research agenda显示文摘 | Leiter MP Harvie PL | 1996 | Int J Soc Psychiatry1996，42，2： | 1 |
| 18 | Increased MRP expression is associated with resistance to radiatinon,anthracycliens and etoposide in cells treated with fracitonated gamma-radiaiton显示文摘 | HARVIE R M DAVEY M W DAVEY R A | 1997 | Int J Cancer1997，73，1： | 1 |
| 19 | The amthracycline resistance-associated (ara)gene,a novcl gene associated with mududurg resistance in human leukaemia cells line 显示文摘 | Longhurst TJ O'Neill GM Harvie RM | 1996 | Br J Cancer:1996，74，912： | 1 |
| 20 | The prediction of mineral solubilities in natural waters:The Na - K - Mg - Ca - H - Cl- SO4 - OH - HCO3 - CO3 - CO2 -H2O system to high ionic strengths at 25 ℃显示文摘 | Harvie C E Mφller N Weare J H | 1984 | Geochimica et Cosmochimica Acta1984，48，4： | 1 |
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