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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | A normal saggital spinal configuration:a desirable clinical outcome显示文摘 | Harrison DD Troyanovich SJ Harrison DE | 1996 | J Manipulative physiol Ther1996，19，6： | 1 |
| 3 | Elliptical modeling of the sagittal lumbar lordosis and segmental rotation angles as a method to discriminate between normal and low back pain subjects显示文摘 | Harrison DD Cailliet R Janik TJ | 1998 | J Spinal Disord1998，11，5： | 1 |
| 4 | Identification and cDNA cloning of two novel low molecular weight host-protective antigens from Taenia ovis oncospheres显示文摘 | Harrison GB Heath DD Dempster RP | 1996 | Int J Parasitol1996，26，2： | 1 |
| 5 | Reliability of centroid,Cobb,and Harrison posterior tangent methods:which to choose foranalysis of thoracic kyphosis显示文摘 | Harrison DE Cailliet R Harrison DD | 2001 | Spine(Phila Pa 1976)2001，11，： | 1 |
| 6 | Reliability of centroid,Cobb,and Harrison posterior tangent methods:which to choose for analysis of thoracic kyphosis?显示文摘 | Harrison DE Cailliet R Harrison DD ET AL | 2001 | Spine2001，26，： | 1 |
| 7 | Cobb method or Har- rison posterior tangent method: which to choose for lateral cervi-cal radiographic analysis 显示文摘 | Harrison DE Harrison DD Cailliet R | 2000 | Spine (Phila Pa 1976)2000，25，16： | 1 |
| 8 | A normal sagittal spinal configuration: A desirable clinical outcome 显示文摘 | Harrison DD Troyanovich SJ Harrison DE | 1996 | JMPT1996，19，6： | 1 |
| 9 | Modeling of the sagittal cervical spine as a method to discriminate hypolordosis:results of elliptical and circular modeling in 72 asymptomatic subjects,52 acute neck pain subjects,and 70 chronic neck pain subjects显示文摘 | Harrison DD Harrison DE Janik TJ | | 0，，： | 1 |
| 10 | A normal sag- ittal spinal configuration: a desirable clinical outcome 显示文摘 | Harrison DD Troyanovich SJ Harrison DE | 1996 | J Ma- nipulative Physiol Ther1996，19，6： | 1 |
| 11 | Reliabilily of centroid cobb, and Harrison posteior tangent meth- ods:which to choose for analysis of thoracic kyphosis 显示文摘 | Harrison DE Cailliet R Harrison DD | 2001 | Spine2001，26，11： | 1 |
| 12 | Cobb method or Harrison posterior tangent method: which to choose for lateralcervical radiographic analysis显示文摘 | Harrison DE Harrison DD Cailliet R | 2000 | Spine2000，25，16： | 1 |
| 13 | Cobb method or Harrison posterior tangent method:which to choose tot lateral cervical radiographic analysis 显示文摘 | Harrison DE Harrison DD Cailliet R | 2000 | Spine2000，25，16： | 1 |
| 14 | Reliability of centroid cobb,and Harrison posterior tangent methods:which to choose for analysis of thoracic kyphosis显示文摘 | Harrison DE Cailliet R Harrison DD | 2001 | Spine (Phila Pa 1976)2001，26，11： | 1 |
| 15 | Cobb method or Harrison posterior tangent method: which to choose for lateral cervical radiographic analysis显示文摘 | Harrison DE Harrison DD Cailliet R | 2000 | Spine (Phila Pa 1976)2000，25，16： | 1 |
| 16 | Reliability of centroid,Cobb,and Harrison posterior tangent methods:which to choose for analysis of thoracic kyphosis显示文摘 | Harrison DE Cailliet R Harrison DD | | 0，，11： | 1 |
| 17 | Taenia ovis recombinant vaccine- quo vadit'显示文摘 | Richard MD Harrison BL Heath DD | 1995 | Parasitology1995，110，： | 1 |
| 18 | Identification of host-protective antigens of Taenia ovis oncospheres显示文摘 | Harrison GBL Heath DD Dempster RP | 1993 | Int J for Parasitol1993，23，： | 1 |
| 19 | Identification and eDNA cloning of two novel low molecular weight host-protective antigens from Toenia ovis oneospheres显示文摘 | Harrison GB Heath DD Dempster RP et ol | 1996 | Int J Parasitol1996，26，2： | 1 |
| 20 | Comparison of axial and flexural stresses in lordosis and three buckled configurations of the cervical spine显示文摘 | Harrison DE Harrison DD Janik TJ | 2001 | Clin giomeeh2001，16，4： | 1 |
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