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| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | Reduced Risk of Tuberculosis among Brazilian Patients with Advanced Human Immunodeficiency Virus Infection Treated with Highly Active Antiretroviral Therapy 显示文摘 | Santoro Lopes G De Pinho AM Harrison LH | 2002 | Clin Infect Dis2002，34，： | 1 |
| 3 | The human immunodeficiency virus type Ⅰ packaging signal and major splice donor region have a conserved stable secondary structure显示文摘 | Lever AM | 1992 | J Virol1992，66，7： | 1 |
| 4 | Effects of GDF5 over-expression on embryonic rat dopaminergic neurones in vitro and invivo显示文摘 | O’Sullivan DB Harrison PT Sullivan AM | 2010 | J Neural Transm2010，5，： | 1 |
| 5 | 显示文摘 | Harrison DJ Candy AM Rae F | 1997 | Hum Exp Toxicol1997，17，： | 1 |
| 6 | Fat and the liver - a molecular overview 显示文摘 | Harrison SA Diehl AM | 2002 | Sere in Gastrointestin Dis2002，13，1： | 1 |
| 7 | A broad spectrum Kunitz type serine protease inhibitor secreted by the hookworm Ancylostoma ceylanicum显示文摘 | Milstone AM Harrison LM Bungiro RD | 2000 | J Biol Chem2000，275，29： | 1 |
| 8 | Progenitor cells in the adult pancreas显示文摘 | GONEZ LJ HARRISON LC | 2004 | Diabetes Metab Res Rev2004，20，1： | 1 |
| 9 | Improving the Ac- curacy of Cardiovascular Component of the Sequential Organ Fail- ure Assessment Score显示文摘 | Yadav H Harrison AM Hanson AC | 2015 | Cri Care Med2015，43，7： | 1 |
| 10 | Fat and the liver amolecular overview显示文摘 | Harrison SA Diehl AM | 2002 | Semin Gastrointest Dis2002，13，1： | 1 |
| 11 | Physical activity patterns and body mass index scores amon gmilitary service members显示文摘 | Harrison L Brennan MA Levine AM | 2000 | Am J Health Promot2000，15，： | 1 |
| 12 | Role of volume-stimulated osmolyte and anion channels in volume regulation by mammalian sperm 显示文摘 | Petrunkina AM Harrison RA Ekhlasi-Hnndrieser M | 2004 | Mol Hum Reprod2004，10，11： | 1 |
| 13 | Treatment of convulsive status epilepticus with propofol:a case report显示文摘 | Harrison AM Lugo RA Schunk JE | 1997 | Pediatr Emerg Care1997，13，3： | 1 |
| 14 | Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women 显示文摘 | Yaffe K Laffan AM Harrison SL | 2011 | JAMA2011，306，6： | 1 |
| 15 | Sleep- disorder- ed breathing, hyp xia, and risk of mild cognitive impair- ment and dementia in older women显示文摘 | Yaffe K Laffan AM Harrison SL | 2011 | JAMA2011，306，6： | 1 |
| 16 | Frequency of glutathione S-transferase M1 deletion in smokers with emphysema and lung cancer显示文摘 | Harrison DJ Cantlay AM Rae F | 1997 | Hum Exp Toxicol1997，16，： | 1 |
| 17 | Myocardial protection for ischemia-reperfusion injury by targeted deletion of matrix metalloproteinase-9显示文摘 | Romanic AM Harrison SM Bao W | 2002 | Cardiovasc Res2002，54，3： | 1 |
| 18 | A patient satisfaction survey comparing evalbuterol with racemic salbutamol in children显示文摘 | Berger We Ames D E Harrison D | 2004 | Allergy Asthma Proc2004，25，： | 1 |
| 19 | Myocardial protection from ischemic/reperfusion injury by targeted deletion of matrix metalloproteinase-9显示文摘 | Romanic AM Harrison SM Bao W | 2002 | Cardiol Res2002，54，： | 1 |
| 20 | Reduced risk of tuberculosis among Brazilian patients with advanced human immunodeficiency virus infection treated with highly active antiretroviral therapy显示文摘 | Santoro-Lopes G Felix AM Harrison LH | 2002 | Clin Infect Dis2002，34，4： | 1 |
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