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| 1 | Hepatocellular carcinoma surveillance:An evidence-based approach显示文摘Hepatocellular carcinoma(HCC) makes up 75%-85% of all primary liver cancers and is the fourth most common cause of cancer related death worldwide. Chronic liver disease is the most significant risk factor for HCC with 80%-90% of new cases occurring in the background of cirrhosis. Studies have shown that early diagnosis of HCC through surveillance programs improve prognosis and availability of curative therapies. All patients with cirrhosis and high-risk hepatitis B patients are at risk for HCC and should undergo surveillance. The recommended surveillance modality is abdominal ultrasound(US) given that it is cost effective and noninvasive with good sensitivity. However, US is limited in obese patients and those with non-alcoholic fatty liver disease(NAFLD). With the current obesity epidemic and rise in the prevalence of NAFLD, abdominal computed tomography or magnetic resonance imaging may be indicated as the primary screening modality in these patients. The addition of alpha-fetoprotein to a surveillance regimen is thought to improve the sensitivity of HCC detection.Further investigation of serum biomarkers is needed. Semiannual screening is the suggested surveillance interval. Surveillance for HCC is underutilized and low adherence disproportionately affects certain demographics such as nonCaucasian race and low socioeconomic status. | Patrick S Harris Ross M Hansen Meagan E Gray Omar I Massoud Brendan M McGuire Mohamed G Shoreibah | 2019 | World Journal of Gastroenterology2019，25，13： | 31 |
| 2 | OPG对TNF诱导的成骨细胞凋亡的抑制作用显示文摘目的 探讨TNF α能否诱导成骨类细胞凋亡及OPG能否抑制其凋亡 ,开辟一条防治骨质疏松的新路。方法 将人间充质干细胞在分化培养液中培养 2 1天使之成为成骨细胞 ,与MG6 3一起用于凋亡实验。鼠WEHI 16 4细胞系用于阳性对照。AnnexinV和TUNEL分析方法检测成骨类细胞凋亡。结果 和FasL诱导细胞凋亡一样 ,TNF α能引起MG6 3骨肉瘤细胞、间充质干细胞和成骨细胞的凋亡 ,并表现为明显的浓度依赖和时间依赖。低浓度TNF α(170~ 5 0 0 pmol/L)作用于细胞 2~ 4h就显示了较明显的凋亡 ,而 0 4 5~1 5nmol/LOPG几乎完全抑制了 5 0 0 pmol/LTNF α诱导的凋亡。结论 OPG能够抑制TNF α诱导的成骨类细胞凋亡。 | 步荣发 李亚男 Jennifer I Oakley Harry C Blair | 2004 | 解放军医学杂志2004，29，4： | 4 |
| 3 | The influence of SiC reinforcement on pitting behavior of aluminum显示文摘 | Trowsdale A J Noble B Harris S J Gibbins I S R | 1996 | Corrosion Science1996，38，： | 2 |
| 4 | The high-molecular-weight subunits of glutenin:structure,genetics and relationship to bread-making quality显示文摘 | Payne P I Harris P A Law C N Holt L M Blackman J A | 1980 | Ann Technol Agric1980，29，2： | 2 |
| 5 | Magnetostrictive properties of polymer bonded Terfenol-D 显示文摘 | Ruiz de Angulo L Abell J Harris I | 1996 | Journal of Magnetism and Magnetic Materials1996，，： | 2 |
| 6 | Randomised phase Ⅱ trial of pegylated liposomal doxorubicin versus doxorubicin in the treatment of advanced or metastatic soft tissue sarcoma : a study by the EORTC soft tissue and bone sarcoma group 显示文摘 | Judson I Radford JA Harris M | 2001 | Eur J Cancer2001，37，7： | 1 |
| 7 | Catalytic cracking of rosin显示文摘 | CLARK I T HARRIS E E | 1952 | Am Chem Soc1952，，74： | 1 |
| 8 | Angiotensin actions in the kidney:renewed insight into the old hormone显示文摘 | ICHIKAWI I HARRIS R C | 1991 | Kidney Int1991，40，： | 1 |
| 9 | Regulation of HMG-CoA synthase and HMG-CoA reductase by insulin and epidermal growth ractor in HaCaT keratinocytes 显示文摘 | Harris I R Hoppner H Siefken W | 2000 | J Invest Dermatol2000，114，1： | 1 |
| 10 | Globus pharyngis: development of a symptom assessment scale 显示文摘 | Deary I J Wilson J A Harris M B | 1995 | J Psychosom Res1995，39，： | 1 |
| 11 | Structural changes in the lumbar interver- tebral discs;their relationship to low back pain and sciatica显示文摘 | Harris R I Macnab I | 1954 | J Bone Joint Surg Br1954，36，2： | 1 |
| 12 | Nature and origin of fracture in Permian coals from the Bowen Basin Queensland, Australia显示文摘 | Gayer R Harris I | 2006 | Coal Bed Methane and Coal Geology2006，109，： | 1 |
| 13 | Carbon foot- printing of lamb and beef production systems: insights from an empirical analysis of farms in Wales, UK显示文摘 | Edwards-Jones G Plassmann K Harris I M | 2009 | The Journal of Agricultural Science2009，147，6： | 1 |
| 14 | Citrus peel use is associated with reduced risk of squamous/ cell carcinoma of the skin显示文摘 | Hakim I A Harris R B Ritenbaugh C | 2000 | Nutr Cancer2000，37，： | 1 |
| 15 | Elevati on of creatine in resting and exercised Muscle of normal subjects by creatine supplementation显示文摘 | Harris I | 1992 | Clinic Science1992，83，： | 1 |
| 16 | Acquired spondelolysis as a sequel to spine fusion显示文摘 | HARRIS R I WILLER J J | 1963 | J Bone Joint Sury (Am)1963，45，6： | 1 |
| 17 | Nitric oxide production and prerivascular tyrosine nitration in brain after carbon monoxide poisoning in the rats显示文摘 | Harry I Michael FB Tsuyoschi S | 1996 | J Clin Invest1996，97，10： | 1 |
| 18 | Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload显示文摘 | Harris IS Zhang S Treskov I | 2004 | Circulation2004，110，6： | 1 |
| 19 | Disproportionation in Nd16Fe76B8-type hydrides 显示文摘 | McGuiness P J Zhang X J Harris I R | 1990 | Journal of the Less Common Metals1990，162，8： | 1 |
| 20 | Direct evidence of oxida live injury produced by the Aizheimer's betaamyloid peptiele显示文摘 | Harris M E Hofer M I | 1995 | Experimental Neurology1995，131，2： | 1 |
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