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| 1 | Geochemical characteristics and diagenetic fluids of dolomite reservoirs in the Huanglong Formation, Eastern Sichuan Basin, China显示文摘Based on a comprehensive study of texture, diagenetic behavior and evolution of dolomite in the Huanglong Formation, trace(e.g., Fe, Mn and Sr) and rare earth element(REE) geochemistry, and isotopic characteristics(e.g., C, O and Sr), four types of diagenetic fluids are identified in the Huanglong Formation dolomite reservoirs of the Eastern Sichuan Basin, China: 1): marine-derived pore waters in the marine diagenetic environment, 2) sabkha compaction brine conserved in the early shallowburied diagenetic environment, 3) strongly-oxidizing low-temperature meteoric water in the seepagesubsurface flow diagenetic environment, and 4) strongly reducing deeply seated mixed hot brine in the middle and deep burial diagenetic environment. The fluids developed hereditarily from one environment to another, which resulted in its respective characteristics. Fluid characteristics play an important role in the development of dolomite reservoirs: 1) dolomitization by marine-derived pore water in the quasisyngenetic stage did not form an effective reservoir; 2) early diagenetic burial dolomitization by the sabkha compaction brine formed the basis for reservoir development; 3) meteoric water karstification in the paleo-epidiagenetic stage expanded both the distribution and the size of the reservoirs, and improved the reservoir quality; 4) deep-burial dissolution and tectonic fracturing in the reburial diagenetic stage further improved reservoir porosity and permeability. | Wen Huaguo Wen Longbin Chen Haoru Zheng Rongcai Dang Lurui Li Yanan | 2014 | Petroleum Science2014，11，1： | 1 |
| 2 | Current status and challenges in the application of microbial PHA particles显示文摘Polyhydroxyalkanoates(PHAs)are diversiform biopolyesters with a similar structure and different side chain groups,synthesized by a variety of microorganism.Due to their excellent biodegradability and biocompatibility,PHAs have been used for many applications,including medical implants,antibacterial agents and bioengineering.Nano-architecture is an emerging area for the use of PHAs.This review summarizes the current status and challenges of PHAs-based particles on the micro-and nano-scale,including their production,degradation,biological safety,and surface functionalization.We also focus on the applications of PHA particles in drug delivery systems,environment protection,tissue engi-neering,vaccine engineering,food science,biotechnology and cosmetics.Finally,the future development trends of PHAs-based particles are prospected. | Jiaxuan Liu Ziqi Zhou Haoru Li Xinyu Yang Zeyu Wang jian Xiao Dai-Xu Wei | 2024 | Particuology2024，87，4： | 0 |
| 3 | The Origin of Paleokarst in the Huanglong Formation of the Eastern Sichuan Basin:Evidence from δ^(13)C, δ^(18)O and ^(87)Sr/^(86)Sr显示文摘Karst rocks from the Huanglong Formation exposed at the margin of the Eastern Sichuan Basin can be divided into four types:slightly corroded, moderately corroded porous, intensely corroded brecciated and intensely corroded and replaced secondary calcic karstic rocks. The carbon, oxygen and strontium isotope compositions of the various karst rocks are analyzed systematically and compared to rocks without karst corrosion. The results indicate that(1) the Huanglong Formation in the eastern Sichuan Basin was a restricted bay supplied and controlled by freshwater in which mudmicrite and mud-dolomicrite exhibit low δ13C and δ18O values and high 87Sr/86 Sr ratios;(2) all types of karstic rocks in the paleokarst reservoirs of the Huanglong Formation in the research area are affected by atmospheric freshwater with the δ13C and δ18O values and 87Sr/86 Sr ratios in the original formation approaching those of atmospheric freshwater, which reflects ancient hydrological conditions, fluid properties, isotopic source and the fractionation effect;(3) the intensely corroded and replaced secondary limestone is affected by a variety of diagenetic fluids, often reflected by δ13C and δ18O values, while the 87Sr/86 Sr ratios exhibit the strong degree of the corrosion;(4) after comparing the 87Sr/86 Sr ratios of each type of karst rock, the diagenetic fluids are determined to be mainly atmospheric freshwater, and depending on the strength of corrosion, and the low 87Sr/86 Sr ratio fluids in the layer will participate in the karst process. The carbon, oxygen, and strontium isotopes of different karstic reservoirs can provide meaningful geochemical information for forecasting and evaluating the development and distribution rules of the Huanglong Formation at the margin of the eastern Sichuan Basin in time and space. | CHEN Haoru ZHENG Rongcai WEN Huaguo LI Shilin LI Shuang ZHOU Gang WEN Longbin | 2014 | Acta Geologica Sinica(English Edition)2014，88，6： | 0 |
| 4 | Comparative metabolomics provides novel insights into the basis of petiole color differences in celery(Apium graveolens L.)显示文摘Plant metabolites are important for plant development and human health.Plants of celery(Apium graveolens L.)with different-colored petioles have been formed in the course of long-term evolution.However,the composition,content distribution,and mechanisms of accumulation of metabolites in different-colored petioles remain elusive.Using ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS),1159 metabolites,including 100 lipids,72 organic acids and derivatives,83 phenylpropanoids and polyketides,and several alkaloids and terpenoids,were quantified in four celery cultivars,each with a different petiole color.There were significant differences in the types and contents of metabolites in celery with different-colored petioles,with the most striking difference between green celery and purple celery,followed by white celery and green celery.Annotated analysis of metabolic pathways showed that the metabolites of the different-colored petioles were significantly enriched in biosynthetic pathways such as anthocyanin,flavonoid,and chlorophyll pathways,suggesting that these metabolic pathways may play a key role in determining petiole color in celery.The content of chlorophyll in green celery was significantly higher than that in other celery cultivars,yellow celery was rich in carotenoids,and the content of anthocyanin in purple celery was significantly higher than that in the other celery cultivars.The color of the celery petioles was significantly correlated with the content of related metabolites.Among the four celery cultivars,the metabolites of the anthocyanin biosynthesis pathway were enriched in purple celery.The results of quantitative real-time polymerase chain reaction(q RT-PCR)suggested that the differential expression of the chalcone synthase(CHS)gene in the anthocyanin biosynthesis pathway might affect the biosynthesis of anthocyanin in celery.In addition,HPLC analysis revealed that cyanidin is the main pigment in purple celery.This study explored the differences in the types and contents of metabolites in celery cultivars with different-colored petioles and identified key substances for color formation.The results provide a theoretical basis and technical support for genetic improvement of celery petiole color. | Mengyao LI Jie LI Haohan TAN Ya LUO Yong ZHANG Qing CHEN Yan WANG Yuanxiu LIN Yunting ZHANG Xiaorong WANG Haoru TANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，4： | 0 |
| 5 | Recent Advances in Glycopeptide and Glycoprotein Synthesis:A Refined Synthetic Probe towards the Biological World显示文摘Comprehensive Summary Protein glycosylation is the most complex and diverse form of post-translational modification in human body.Meanwhile,glycosylation of peptides and proteins emerges as a promising strategy to improve the pharmacokinetic profile of peptide-and protein-based therapeutics.Owing to the importance of protein glycosylation,a rigorous evaluation of the relationship between the precise structure and biological function of glycoproteins has to be performed.Recently,chemical synthesis,chemoenzymatic synthesis and semisynthesis strategies have attracted extensive attentions towards the preparation of structurally defined glycopeptides and glycoproteins;the obtained synthetic glycoforms thus enable the thorough investigation of specific effects of protein glycosylation. | Haoru Zhuang Huiran Hao Yongshun Qiu Jinjuan Gan Tianlu Li | 2023 | Chinese Journal of Chemistry2023，41，16： | 0 |
| 6 | Effects Analysis of Mg^2+, dNTPs and Taq DNA Polymerase on SSR-PCR System of Pear显示文摘 | Min Lu Xiaoyang Chen Ling Lin Ya Luo Yong Zhang Zejing Liu Liyi Li Haoru Tang | 2011 | Journal of Life Sciences2011，5，6： | 0 |
| 7 | Application Status,Problems and Countermeasures of Dairy Herd Improvement( DHI) in Dairy Buffalo Industry显示文摘The development of buffalo milk industry in China encounters the problems of small high yield populations and insufficient excellent provenance. Therefore,it is necessary to carry out dairy herd improvement( DHI) to increase dairy buffalo herd productivity. This paper reviewed the situation and problems of DHI in dairy buffalo,and the corresponding opinions and suggestions were put forward. | Lin Bo Li Ling Tang Yan Nong Haoru Zeng Qingkun | 2016 | Animal Husbandry and Feed Science2016，8，1： | 0 |
| 8 | Nanomaterials for neurodegenerative diseases:Molecular mechanisms guided design and applications显示文摘Successful treatment of neurodegenerative diseases(NDDs),including Alzheimer’s disease(AD),Parkinson’s disease(PD),and Huntington’s disease(HD),remains a significant challenge for neurologists due to the undesirable curative outcomes.Apart from surgeries,most drugs are only used to relieve the patients’symptoms without a permanent cure of the disease.The development of novel biomaterials targeting NDDs is greatly hindered by the limited understanding of underlying molecular mechanisms.Considering the difficulties in NDD drug development and clinical trials,a comprehensive and up-to-date review of disease pathogenesis and related novel therapies are needed.In the current article,the basic concepts and pathogenic characteristics of NDDs are firstly illustrated.Following the detailed description of molecular mechanisms underlying three common NDDs,recent advances of drug development based on targeting different pathogenic mechanisms are clarified.Hopefully,this review will be beneficial to address the gap between materials and targeted mechanisms while simultaneously provide suggestions for the future design of precise NDD medicine. | Tianzhong Li Xueyan Hou Yu Qi Xiaohan Duan Pengcheng Yan Haoru Zhu Zhongjian Xie Han Zhang | 2022 | Nano Research2022，15，4： | 0 |
| 9 | Divergent Synthesis of Core m1,Core m2 and Core m3 O-Mannosyi Glycopeptides via a Chemoenzymatic Approach显示文摘O-Mannosylation plays a vital role in the regulation of a variety range of biological processes,for instance,brain and muscle development.However,the precise function remains largely unknown due to its innate heterogeneity.In this regard,it is still welcome to develop efficient methods to access diverse structurally-defined glycopeptides.In this study,a diversity-oriented assembly of O-mannosylα-dystroglycan(α-DG)glycopeptides has been achieved via a chemoenzymatic strategy.This strategy features(i)gram scale divergent synthesis of core m1,core m2 and core m3 mannosylated amino acids from judiciously designed protecting group strategies and chemical glycosidation;(i)efficient glycopeptide assembly via the optimized microwave-assisted solid phase peptide synthesis(SPpS);and(ii)enzymatic elaboration of the core glycan structures to install galactosyl and sialyl-galactosyl moieties.The efficiency and flexibility of this chemoenzymatic approach was demonstrated with the construction of 12 glycopeptides with different core m1,core m2 and core m3 mannosyl glycans,including a core m2 glycopeptide bearing a heptasaccharide for the first time. | Tianlu Li Youqin Zhang Tong Li Haoru Zhuang Fengshan Wang Ning Wang Richard R.Schmidt Peng Peng | 2022 | Chinese Journal of Chemistry2022，40，13： | 0 |
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