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| 1 | Split liver transplantation: a reliable approach to expand donor pool显示文摘Orthotopic liver transplantation as a successful treatment of end-stage liver disease is hampered by a persistent lack of cadaveric organs. Split liver transplantation, which was first successfully performed by Medical School of Hannover in 1988, has become a mature surgical technique to expand the donor pool. Between 1993 and 1999, split liver transplantation activities have increased in Europe from 1. 2% to 10. 4% in all performed liver transplantations. Current data have strongly supported that the survival rate of patients after split liver transplantation is not significantly different from that of patients after whole-size orthotopic liver transplantation. The most important step of donor graft selection is surgeon’ s observation judged by the experience of individual transplant center. The paper aims to provide the guideline of donor selection, hepatic graft splitting, and recipient management as well. DATA SOURCES: Medical School of Hannover has accumulated plentiful experience of split liver transplantation for more than 10 cases ever since 1998. Besides that, we also reviewed a variety of literatures from other famous European and American centers specialized in this field for many years. RESULTS:According to our experience combined with the view points of others, the donor should meet the following criteria as well: (1) age less than 50 years; (2) hemodynamics stable; (3) ICU less than 5 days; (4) Na less than 170 mmol/L or better if less than 150 mmol/L. In 1996 and 1997, the Hamburg group and the UCLA group separately introduced a breakthrough technique performing split liver transplantation in situ. Evidently, the in situ technique has been limited by prolonged time of donor organ procurement , coordination with other organ procurement teams, and even extra burden on donor hospital. Some groups, therefore, have restored the ex situ or bench splitting technique , and fortunately the transplant outcomes of the ex situ technique are equivalent to those of the in situ one. Recently some new techniques have been introduced to split the liver for two adult patients, including the split-cava technique. CONCLUSIONS:It is clear that the most important factor for determining the prognosis of the patient is the time of receiving liver transplantation, not the type of liver transplantation. We still need to pay close attention to the graft to recipient weight ratio (GRWR) and the UNOS classification or MELD score before the patient is subjected to split liver transplantation. | Ji-Qi Yan, Thomas Becker, Cheng-Hong Peng, Hong-Wei Li and Juergen Klempnauer Department of Surgery, Ruijin Hospital Affiliated to Shanghai Second Medical University, Shanghai 200025, China ( Yan JQ, Peng CH and Li HW) Department of Abdominal and Transplant Surgery, Medical School of Hannover, Carl-Neuberg-Str. 1 , 30625 Hannover, Germany | 2005 | Hepatobiliary & Pancreatic Diseases International2005，4，3： | 3 |
| 2 | Geometric and information potential of IRS-1 C PAN-images 显示文摘 | Jacobsen K Hannover Univ | 1999 | International Geoseience and Remote Sensing Symposium1999，，1： | 1 |
| 3 | Detection of small transverse cracks in rotating shafts显示文摘 | B O Dirr K Popp and W Rothkegel Hannover | 1994 | Archive of Applied Mechanics1994，64，： | 1 |
| 4 | Itow self-construal affects dispositionalism in attributions 显示文摘 | Ktihnen U Hannover B Ptihlmann C & Roeder U | 2013 | Social Cognition2013，，2： | 1 |
| 5 | Investigation of Brillouin scattering in optical fibers for the generation of millimeter waves显示文摘 | Schneider T Hannover D Junker M | 2006 | J Lightwave Technol2006，24，1： | 1 |
| 6 | Don't Stand so Close to Me-The Effects of Self-Con- strual on Interpersonal Closeness 显示文摘 | Holland R W Roeder U R van Baaren R B Brandt A C Hannover B | 2004 | Psychological Science2004，15，4： | 1 |
| 7 | The influence of thinness and smoking on bone loss and response to hormone replacement therapyin early postmenopansal women显示文摘 | Nina Hannover Bjamason and Claus Christiansen | 2000 | Clin Endocrinol Metab2000，85，： | 1 |
| 8 | DWI在颅脑肿瘤鉴别诊断中的应用显示文摘DWI不仅对脑卒中的诊断有帮助,而且在颅脑肿瘤的鉴别诊断中也有一定的应用价值。在Eur J Radiol(2005;55:393—400)的论文中讨论了最小弥散系数的数值,这个值对于颅脑肿瘤的鉴别诊断有重要意义。 | Rüdiger Meyer,Hannover 曹毅媛(译) 漆剑频(校) | 2006 | 放射学实践2006，21，7： | 1 |
| 9 | Don’t stand close to me:the effects of self-construal on interpersonal closeness显示文摘 | Holland R W Roeder U R Baaren R B Brandt A C&Hannover B | 2004 | Psychological Science2004，15，4： | 1 |
| 10 | Powder rubber processing 显示文摘 | Capelle G Meier G Hannover | 1982 | Kunststoffe1982，72，7： | 1 |
| 11 | Generation of millimetre-wave signals by stimulated Brillouin scattering for radio over fibre systems显示文摘 | T Schneider M Junker D Hannover | 2004 | Electronics Letters2004，40，23： | 1 |
| 12 | D NUMERICAL MODELLING OF NON-COHESIVE SEDIMENT TRANSPORT ON LOOSE AND RIGID BEDS显示文摘3DNUMERICALMODELLINGOFNON-COHESIVESEDIMENTTRANSPORTONLOOSEANDRIGIDBEDS￥RobertoMayerle(ResearchEngineer,InstituteofFluidMeched... | Roberto Mayerle( Institute of Fluid Mechedcs and Computer Applications in Civil Engineering,University of Hannover, Appelstr. 9 A, D-30167, Hannover, Germany.) | 1994 | International Journal of Sediment Research1994，9，3： | 1 |
| 13 | Residual stressmeasurement and cause in machining process显示文摘 | Brinmsmeier E Hannover J Cammett T | 1982 | Annals of the CIRP1982，31，2： | 1 |
| 14 | Residual stress-measurement and cause in machining process显示文摘 | BRINKSMEIER E HANNOVER CAMMETT J T | 1982 | Annals of the CIRP1982，31，2： | 1 |
| 15 | Examination of preser- vation of the qualify of sand shrimp after treatment with ozoned wa- ter and ozoned ice 显示文摘 | Sassen K Tieraeztliche Hochsch Hannover | 1989 | Unterschungen zur Qualitaetserhahung yon Nordseegamelen Bibliggr1989，，119： | 1 |
| 16 | Multiple healthrisk behaviors in German first year university students显示文摘 | KELLER S MADDOCK JE HANNOVER W | 2008 | Prev Med2008，46，3： | 1 |
| 17 | Optimierung der gewinnung von maltosesirupen durch verschiedene enzymkombinationen显示文摘 | TEGGE V G DETMOLD G R HANNOVER G R | 1986 | Stareh/St(a)rke1986，38，： | 1 |
| 18 | Residual stress-measurement and cause in machining process显示文摘 | Brinksmeier E Hannover Cammett J T | 1982 | Annals of the CIRP1982，31，2： | 1 |
| 19 | Culture, Self-constrnal and Regu- latory Focus: How and What to Promote or Prevent? 显示文摘 | Kuhnen U Hannover B | 2010 | Psychological Inquiry2010，21，： | 1 |
| 20 | Residual stress-measurement and cause in machining process显示文摘 | Hannover J Cammett T | 1982 | Annals of the CIRP1982，31，2： | 1 |
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