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| 1 | Delivering PD-1 inhibitory signal concomitant with blocking ICOS co-stimulation suppresses lupuslike syndrome in autoimmune BXSB mice 显示文摘 | Hanlu Ding Wu Xiongfei Wenda Gao | 2006 | Clin Immunol2006，118，23： | 1 |
| 2 | Po-L1 is expressed by human renal tubular epithelial cell and suppresses T cell cytokine synthesis显示文摘 | Hanlu Ding Xiongfei Wu Wenda Gao | 2005 | Clin Immunol2005，115，2： | 1 |
| 3 | Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin overload显示文摘 | Jurong Yang Yani He Haiying Shen Hanlu Ding Kailong Li Huiming Wang | 2008 | Frontiers of Medicine in China2008，，1： | 1 |
| 4 | Surgical correction for scimitar syndrome by right thoracotomy and direct anastomosis in chUdren显示文摘Importance:Scimitar syndrome(SS)is a rare type of congenital heart disease characterized by total or partial anomalous venous drainage of the right lung to the inferior vena cava.However,the surgical repair techniques for SS vary according to patients'anatomical and pathological features.Objective:This study was performed to analyze the mid-term results of a less invasive surgical correction technique for SS in children.Methods:Eleven patients with SS who underwent surgical repair from January 2012 to March 2020 were retrospectively analyzed.The anomalous scimitar vein(SV)was directly reimplanted to the left atrium,and the concomitant atrial septal defect was simultaneously repaired with cardiopulmonary bypass.Results:Three male and eight female patients were included in the study.Their mean age was 3.1±1.3 years,and their mean body weight was 12.8±3.0 kg.Most patients had symptoms,such as upper respiratory tract infection,dyspnea,and recurrent pneumonia,and two patients had pulmonary hypertension.None of the 11 patients who underwent direct SV reimplantation by right thoracotomy developed bleeding,arrhythmia,heart failure,or perioperative death,and no patients required reoperation during a mean follow-up period of 36.6±15.2 months.Postoperative echocardiography revealed no restenosis or obstruction of the anastomosis in any patients.Interpretation:Surgical repair for SS by right thoracotomy and direct anastomosis of the SV to the posterior wall of the left atrium is safe and effective,with good long-term patency of the reimplanted SV and a low mortality rate. | Wei Cheng Zhiqiang Li Yaobin Zhu Nan Ding Daole Yan Hanlu Yi | 2021 | Pediatric Investigation2021，5，1： | 0 |
| 5 | Expression of renal cubilin and its potential role in tubulointerstitial inflammation induced by albumin overload显示文摘Sustained proteinuria is an independent risk factor leading to kidney fibrosis and end-stage renal fail-ure.Over-reabsorption of filtered proteins,notably albu-min,has been proved to trigger interstitial inflammation and fibrosis in proteinuric renal disease.Cubilin,an endo-cytic receptor expressed on the renal tubular brush bor-der,is responsible for albumin reabsorption in physiologic condition.However,little is known about whether it is required for activation of tubular cells induced by albu-min overload.In this work,we investigated the change of cubilin expression and its potential role in albumin-induced up-regulation of chemokines synthesis in vivo and in vitro.Twenty-six patients with nephrotic syndrome were enrolled in this study.Proximal tubule uptake of albumin,expression of apical membrane cubilin and infiltrating cells in kidney interstitium were determined by immunocytochemistry.In vitro,the transcription of cubilin in HK2 cells after exposure to albumin was ana-lyzed by real-time PCR.Endocytosis of albumin in HK2 cells was examined by fluorescent microscope.The influ-ence of inhibition of cubilin on albumin-induced expres-sions of monocyte chemoattractant protein 1(MCP-1)and regulated upon activation normal T-cell expressed and secreted(RANTES)was investigated by Western blot.The intensity of luminal cubilin and tubular accu-mulation of albumin were significantly increased in nephrotic kidneys.The expression of MCP-1 and RANTES was up-regulated,and there were spatial rela-tionships in localization between these chemokines and cubilin as well as intracellular albumin in kidney tissues.Infiltration of CD-3 and ED-1-positive cells was predom-inant in tubulointerstitial areas displaying signs of increases of cubilin expression and albumin accumula-tion.In vitro,the transcription of cubilin mRNA in HK2 cells was enhanced after 24 h exposure to albumin in a dose-dependent manner.Inhibition of endocytosis of albumin by antisense cubilin nucleotide markedly reduced expression of MCP-1 and RANTES.Cubilin was required for handling a greater amount of protein in nephrotic status and albumin-induced production of MCP-1 and RANTES by renal tubular cells,which further initiated tubulointerstitial inflammation in proteinuric disease. | Jurong YANG Yani HE Haiying SHEN Hanlu DING Kailong LI Huiming WANG | 2008 | Frontiers of Medicine2008，2，1： | 0 |
| 6 | A Review of the Eco-Environmental Impacts of the South-to-North Water Diversion:Implications for Interbasin Water Transfers显示文摘Interbasin water-transfer schemes provide an engineering solution for reconciling the conflict between water demand and availability.In the context of climate change,which brings great uncertainties to water resource distribution,interbasin water transfer plays an increasingly important role in the global water–food–energy nexus.However,the transfer of water resources simultaneously changes the hydrological regime and the characteristics of local water bodies,affecting biotic communities accordingly.Compared with high economic and technical inputs water-transfer projects require,the environmental and ecological implications of water-transfer schemes have been inadequately addressed.This work selects the largest water-transfer project in China,the South-to-North Water Diversion(SNWD)Project,to critically review its eco-environmental impacts on donor and recipient basins,as well as on regions along the diversion route.The two operated routes of the SNWD Project represent two typical water diversion approaches:The Middle Route uses an excavated canal,while the East Route connects existent river channels.An overview of the eco-environmental implications of these two routes is valuable for the design and optimization of future water-transfer megaprojects. | Hanlu Yan Yuqing Lin Qiuwen Chen Jianyun Zhang Shufeng He Tao Feng Zhiyuan Wang Cheng Chen Jue Ding | 2023 | Engineering2023，，11： | 0 |
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