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| 1 | Association between high cystatin C levels and carotid atherosclerosis显示文摘AIM To investigate the association between carotid atherosclerosis and cystatin C(CysC) and to determine the optimal CysC cut-off value.METHODS One hundred twenty-eight subjects were included in this study. Atherosclerosis was defined as a maximum carotid plaque thickness(MCPT) of greater than 2 mm. A receiver operating characteristic curve analysis was used to determine the diagnostic value of serum CysC for atherosclerosis. The subjects were divided into two groups according to the CysC cut-off value. We screenedfor diabetes, hypertension, dyslipidemia, smoking status, alcohol consumption, and exercise behavior. The association between atherosclerosis and CysC levels was assessed using multivariate analysis.RESULTS The subjects were then divided into two groups according to the CysC cut-off value(0.73 mg/L). The median age of the high CysC group was 72 years(85% males), whereas that of the low CysC group was 61 years(63% males). The CysC levels were significantly correlated with Cr and estimated glomerular filtration rate(eGFR) values. Bodymass index, visceral fat area, hypertension, diabetes mellitus, and MCPT were significantly higher in the high CysC group than in the low CysC group. Furthermore, the eG FR was significantly lower in the high CysC group. Regarding lifestyle habits, only the exercise level was lower in the high CysC group than in the low CysC group. Multivariate analysis, adjusted for age and sex, revealed that high CysC levels were significantly associated with an MCPT of ≥ 2 mm(odds ratio: 2.92; 95%CI: 1.13-7.99).CONCLUSION Higher CysC levels were associated with an MCPT of ≥ 2 mm. The CysC cut-off value of 0.73 mg/L appears to aid in the diagnosis of atherosclerosis. | Toshiyuki Kobayashi Hirohide Yokokawa Kazutoshi Fujibayashi Tomomi Haniu Teruhiko Hisaoka Hiroshi Fukuda Toshio Naito | 2017 | World Journal of Cardiology2017，9，2： | 26 |
| 2 | Aerodynamic forces acting on two square prisms placed vertically in a turbulent boundary layer显示文摘 | Sakamoto H Haniu H | 1988 | Journal of Wind Engineering and Industrial Aerodynamics1988，31，： | 2 |
| 3 | Aerodynamic forces acting on two square prisms placed vertically in a turbulent boundary layer 显示文摘 | Sakamoto H Haniu H | 1988 | Journal of Wind Engineering and Industrial Aerodynamics1988，，31： | 1 |
| 4 | Glial cell line-derived neurotrophic factor:selective reduction of the intermolecular disulfide linkage and characterizaion of its disulfide structure显示文摘 | Haniu M Hui J Yong Y | 1996 | Bioche-mistry1996，35，16： | 1 |
| 5 | A furin-like covertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase 显示文摘 | Bennett BD Denis P Haniu M | 2000 | The journal of biological chemistry2000，275，37： | 1 |
| 6 | Aerodynamic forces acting on two square prism placed vertically in a turbulent bound- ary layer显示文摘 | SAKAMOTO H HANIU H | 1988 | Journal of Wind Engineering and Industrial Aerodynamics1988，31，1： | 1 |
| 7 | Aerodynamic forces acting on two square prisms placed vertically in a turbulent boundary layer 显示文摘 | Interference effects on on prismatic bodies in Industrial Journal of SAKAMOTO H HANIU H | 1988 | Journal of Wind Engineering and Industrial Aerodynamics1988，31，： | 1 |
| 8 | Heart-type fatty-acid-binding protein (FABP3) is a lysophosphatidic acid-binding protein in human coronary artery endothelial cells显示文摘 | Ryoko Tsukahara Hisao Haniu Yoshikazu Matsuda Tamotsu Tsukahara | 2014 | FEBS Open Bio2014，，： | 1 |
| 9 | Cyclic phosphatidic acid in- hibits the secretion of vascular endothelial growth factor from diabetichu- man coronary artery endothelial cells through peroxisome proliferator- activated receptorgamma显示文摘 | Tsukahara T Tsukahara R Haniu H | 2015 | Mol Cell Endocrinol2015，412，： | 1 |
| 10 | Cytochrome P450c17 (steroid 17 alpha-hydroxylase/17,20 lyase): cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues显示文摘 | Chung BC Picado-Leonard J Haniu M | 1987 | Proc Natl Acad Sci U S A1987，84，2： | 1 |
| 11 | Aerodynamic forces acting on two squaxe prisms placed vertically in a turbulent boundary layer显示文摘 | Sakamoto H Haniu H | 1988 | J of Wind Engng Indust Aerodyn1988，，31： | 1 |
| 12 | Optimal suppression of fluid forces acting on a circular cylinder显示文摘 | Sakamoto H Haniu H | 1994 | Journal of Fluids Engineering1994，116，： | 1 |
| 13 | Medical application of carbon-nanotube-filled nanocomposites:The microcatheter显示文摘 | Koyama S Haniu H Osaka K | 2006 | Small2006，2，12： | 1 |
| 14 | Cytochrome P450c17 ( steroid 17 alpha-hydroxylase/17,20 lyase) : cloning of human adrenal and testis cDNAs indicates the same gene is expressed in both tissues 显示文摘 | Chung BC Picado-Leonard J Haniu M | 1987 | Proc Natl Acad Sci1987，84，2： | 1 |
| 15 | Disulfide bonds in recombinant human platelet-derivedgrowth factor BB dimer: characterization of intermolecular and intramolecular disulfidelinkages显示文摘 | Haniu M Rohde MF Kenney WC | 1993 | Biochemistry1993，32，9： | 1 |
| 16 | Aerodynamic forces act ing on two square prisms placed vertically in a turbulent boundary layer显示文摘 | SAKAMOTO H HANIU H | 1988 | Journal of Wind Engineering and Industrial Aerodynamics1988，，31： | 1 |
| 17 | Identification of 4-hydroxynonenal-modified retinal proteins induced by photooxidative stress prior to retinal degeneration 显示文摘 | Tanito M Haniu H Elliott MH | 2006 | Free Radic Biol Med2006，41，12： | 1 |
| 18 | Yoshixol^TR inhibits B16 melanoma cell growth in vivo and induces apoptosis-like( quantum thermodynamic) cell death 显示文摘 | Koyama S Tanaka S Haniu H | 1999 | Gen Pharmacol1999，33，2： | 1 |
| 19 | The formation mechanism and shedding frequency of vortices from a sphere in uniform shear flow显示文摘 | SAKAMOTO H HANIU H | 1995 | Journal of Fluid Mechanics1995，287，： | 1 |
| 20 | Fluctuating Forces Acting on Two Square Prisms in Tandem Arrangement显示文摘 | H Sakamoto H Haniu Y Obata | 1987 | Journal of Wind Engineering and Industrial Aerodynamics1987，，26： | 1 |
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