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| 1 | Hepatic schwannoma:Imaging findings on CT,MRI and contrast-enhanced ultrasonography显示文摘A primary benign schwannoma of the liver is extremely rare and is difficult to preoperatively discriminate from a malignant tumor.We compared the imaging and pathological findings,and examined the possibility of preoperatively diagnosing a benign liver schwannoma.A 72-year-old woman was admitted to our hospital because of a 4.6-cm mass in the liver.A malignant tumor was suspected,and a right hepatectomy was performed.After this,the diagnosis of a primary benign schwannoma of the liver was made through pathological examination.Contrast-enhanced ultrasonography(CEUS) with Sonazoid showed minute blood flows into the septum and solid areas of the tumor in the vascular phase;most likely due to increased arterial flow associated with infiltration of chronic inflammatory cells.In the postvascular phase,CEUS showed contrast defect of cystic areas and delayed enhancement of solid areas;most likely due to aggregation of siderophores.Because discriminating between a benign and malignant schwannoma of the liver is difficult,surgery is generally recommended.However,the two key findings from CEUS may be useful in discriminating ancient schwannoma by recognizing the hemorrhage involved in the secondary degeneration and aggregation of siderophores. | Yu Ota Kazunobu Aso Kenji Watanabe Takahiro Einama Koji Imai Hidenori Karasaki Ryuji Sudo Yosui Tamaki Mituyoshi Okada Yosihiko Tokusashi Toru Kono Naoyuki Miyokawa Masakazu Haneda Masahiko Taniguchi Hiroyuki Furukawa | 2012 | World Journal of Gastroenterology2012，18，35： | 11 |
| 2 | Inhibitory effect of angiotensinⅡreceptor antagonist on hepatic stellate cell activation in non-alcoholic steatohepatitis显示文摘AIM: To investigate the efficacy of angiotensinⅡreceptor antagonist on hepatic stellate cells (HSCs) activation in the patients with non-alcoholic steatohepatitis (NASH). METHODS: Seven patients with NASH were prescribed losartan, a selective angiotensinⅡtype 1 receptor antagonist (50 mg/d) for 48 wk. Liver biopsies were performed both at the entry and end of the study in all patients. Quiescent and activated HSCs were identified by double immunostaining using anti-p75 andα-smooth muscle actin antibodies, and the number of each phenotype was counted. Similarly, the liver specimens obtained from the eight patients with non-alcoholic fatty liver (NAFL) were also examined as controls. RESULTS: In NASH hepatic tissues, activated HSCs were dominantly distributed as compared with those in NAFL. The 48-wk losartan treatment induced a remarkable decrease in activated HSCs and a mild increase in quiescent phenotypes. CONCLUSION: Our data suggest the crucial involvement of HSCs in anti-fibrotic effect of angiotensinⅡreceptor antagonist on patients with NASH. | Shiro Yokohama Yoshihiko Tokusashi Kimihide Nakamura Yosui Tamaki Satoshi Okamoto Mituyoshi Okada Kazunobu Aso Takenao Hasegawa Masaru Aoshima Naoyuki Miyokawa Masakazu Haneda Masashi Yoneda | 2006 | World Journal of Gastroenterology2006，12，2： | 10 |
| 3 | Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model显示文摘 | Kunio Hirata Shinji Kume Shin-ichi Araki Masayoshi Sakaguchi Masami Chin-Kanasaki Keiji Isshiki Toshiro Sugimoto Akira Nishiyama Daisuke Koya Masakazu Haneda Atsunori Kashiwagi Takashi Uzu | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 2 |
| 4 | Measuring the change in R&D efficiency of the Japanese pharmaceutical industry显示文摘 | Akihiro Hashimoto Shoko Haneda | 2008 | Research Policy2008，，10： | 2 |
| 5 | Promotional effect of H 2 O on the activity of In 2 O 3 ‐doped Ga 2 O 3 –Al 2 O 3 for the selective reduction of nitrogen monoxide显示文摘 | Masaaki Haneda Yoshiaki Kintaichi Hideaki Hamada | 1998 | Catalysis Letters1998，，1： | 2 |
| 6 | Removal of estrogenic activities of bisphenol A and nonylphenol by oxidative enzymes from lignin-degrading basidiomycetes显示文摘 | Tsutsumi Y Haneda T Nishida T | 2001 | Chemosphere2001，42，： | 1 |
| 7 | Coronary Risk Factors in Acute Kawasaki Disease:Correlation of Serum Immunoglobulin Levels with Coronary Complications显示文摘 | Sawaji Y Haneda N Yamaguchi S | 1998 | Acta Paediatr Jpn1998，40，： | 1 |
| 8 | Enhancement of glomerular hemeoxygenase-1 expression in diabetic rats显示文摘 | Hayashi K Haneda M Koya D | 2001 | Diabetes Res Clin Pract2001，52，2： | 1 |
| 9 | Visible-light-driven N-F-codoped TiO2 Photocatalysts(2) : optical characterization, photocatalysis, and potential application to air purification 显示文摘 | Li D Haneda H Hishita S | 2005 | Chem Mater2005，17，10： | 1 |
| 10 | Measuring the change in R&D efficiency of the Japanese pharmaceutical industry 显示文摘 | A Hashimoto S Haneda | 2008 | Research Policy Volume 37 Issue 102008，2008，： | 1 |
| 11 | Cellular mechanisms in the development and progression of diabetic nephropathy : activa- tion of the DAG-PKC-ERK pathway 显示文摘 | Haneda M Koya D Kikkawa R | 2001 | Am J Kidney Dis2001，38，41： | 1 |
| 12 | Predictive effects of urinary liver-type fatty acid-binding protein for deterio- rating renal function and incidence of cardiovascular dis- ease in type 2 diabetic patients without advanced nephropathy显示文摘 | Araki S Haneda M Koya D | 2013 | Diabetes Care2013，36，5： | 1 |
| 13 | Magnetic Structure of Small NiFe204 Particles 显示文摘 | Morrish A H Haneda K | 1981 | J Appl Phy1981，52，： | 1 |
| 14 | Luminescence in Cu-implanted ZnO thin films显示文摘 | Sakaguchi I Hishita S Haneda H | 2004 | Appl Surf Sci2004，237，14： | 1 |
| 15 | Thiazolidinedione compounds ameliorate glomerular dysfunction independent of their insulin-sensitizing action in diabetic rat显示文摘 | Isshiki K Haneda M koya D | 2000 | Diabetes2000，49，6： | 1 |
| 16 | Progression of diabetic nephropathy显示文摘 | Kikkawa R Koya D Haneda M | 2003 | J Am Kidney Dis2003，41，： | 1 |
| 17 | Overview of glucose signaling in mesangial cells in diabetic nephropathy显示文摘 | Haneda M Koya D Isono M | 2003 | J Am Soc Nephrol2003，，： | 1 |
| 18 | Photocatalysis of sprayed nitrogen-containing Fe2O3-ZnO and WO3-ZnO composite powders in gasphase acetaldehyde decomposition显示文摘 | Li Di Haneda Hajime | 2003 | Journal of Photochemistry and Photobiology A: Chemistry2003，160，： | 1 |
| 19 | Prooxidant activity of curcumin: copper-dependent formation of 8-hy- droxy-20-deoxyguanosine in DNA and induction of apoptotic cell death显示文摘 | Yoshino M Haneda M Naruse M | 2004 | Toxicol In Vitro2004，18，6： | 1 |
| 20 | Promotional effect of SO2 on the activity of Ir/SiO2 or NOx reduction with CO under oxygenrich conditions显示文摘 | Haneda M Pusparatu Kintaichi Y | 2005 | Journal of catalysis2005，229，1： | 1 |
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