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| 1 | Local immunotherapy with interleuk in-2 delivered from biodegradable p olymer microspheres combined with interstitial chemotherapy:a novel treatme nt for experimental malignant glioma显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradable polymers prolon gs survival against experimental brain tumors.Moreover,paracrine administration of inte rleukin-2(IL-2)has been shown to elicit a potent antitumor immune response and to improve survival in animal brain tumor models.We r eport the use of a novel polymeric mic rosphere delivery vehicle to release IL-2.We demonstr ate both in vitro release of cytokine from the microspheres and histological evidence of the inflammatory response elicited by I L-2released from the microspheres i n the rat brain.These microspheres a re used to deliver IL-2,and biodegradable polymer wafers are used to deliver BCNU,directly at the site of an intracranially implanted glioma in the rat.The two agents administered locally show a s ynergistic effect.METHODS:Fischer 344rats challenged intracranially with 9L gliosarcoma received an intracranial implant of either empty microspheres or microspheres containing IL-2(IL-2MS ).Five days later,animals in each group were randomized to receiv e polymer implants loaded with 0,3.8,or 10%BCNU at the tumor site.RESULTS:Animals that received the combination of IL-2MS a nd 3.8%BCNU polymer(median survival,28.5d )or IL-2MS and 10%BCNU polymer(median survival,45.5d )showed significantly improved surv ival compared with animals that rece ived monotherapy with IL-2microsph eres(median survival,24d ),3.8%BCNU polymer(median survival,24d ),or 10%BCNU polymer(median survival,32.5d ).Control animals had a median survival of 18days.The combination of either 3.8or 10%BCNU polymer with IL-2MS resulted in 7and 25%long-term survivors,respectively.CONCLUSION:By showing synergy of IL-2and BCNU in an animal glioma model and using a reproducible synthetic delivery sy stem for each agent (i.e.,one that did not rely on genetic ally engineered cells or viruses),we hope that the combination of local immunotherapy and chemotherapy can take an important step closer to clinical applic ation in patients with malignant brain | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 癌症2003，22，7： | 2 |
| 2 | Effectiveness of a strategy to improve adherence to tuberculosis treatment in a resource-poor setting: a cluster randomized controlled trial 显示文摘 | Thiam S Le Fevre A M Hane F | 2007 | JAMA2007，297，40： | 1 |
| 3 | Evaluation of the prognostic value of IFN-gamma release assay and tuberculin skin test in household contacts of infectious tuberculosis cases in Senegal 显示文摘 | Lienhardt C Fielding K Hane AA Niang A Ndao CT Karam F Fletcher H Mbow F Oomis JF Diadhiou R Toupane M Dieye T Mboup S | 2010 | PLoS One2010，5，10： | 1 |
| 4 | Martensitic Transformations and Shape-Memory Materials显示文摘 | R D James and K F Hane | 2000 | Act Mater2000，48，： | 1 |
| 5 | Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats显示文摘 | DIMECO F RHINES L D HANES J | 2000 | J Neurosurg2000，92，3： | 1 |
| 6 | Kelvin probe force microscopy in application to biomolecular films: Frequency modulation, amplitude modulation, and lift mode 显示文摘 | Moores B Hane F Eng L | 2010 | Ultramicroscopy2010，110，6： | 1 |
| 7 | Effect of metals on kinetic pathways of amyloid- β aggregation显示文摘 | Hane F Leonenko Z | 2014 | Biomolecules2014，4，1： | 1 |
| 8 | On the CFD modeling of Taylor flow in microehannels 显示文摘 | GUPTA R FLETCHER D F HANES B S | 2009 | Chemical Engineering Science2009，64，： | 1 |
| 9 | Determination of dibenzo-p-dioxin (DBD) and dibenzofuran (DBF) in paper pulp mill defoamer additives and in paper pulp samples显示文摘 | VANNESS G F TIERNAN T O HANES M S | 1990 | Chemosphere1990，20，1012： | 1 |
| 10 | 显示文摘 | DiMeco F Rhines LD Hanes J | 2000 | J Neurosurg2000，92，3： | 1 |
| 11 | Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats显示文摘 | DiMeco F Rhines LD Hanes J | 2000 | J Neurosurg2000，92，3： | 1 |
| 12 | An efficient mode-splitting method for a curvihnear nearshore circulation model显示文摘 | SHI F KIRBY J T HANES D M | 2007 | Coastal Engineering2007，54，： | 1 |
| 13 | Effect of SP - C on surface potential distribution in pulmonary surfactant:Atomic force microscopy and Kelvin probe force microscopy study 显示文摘 | Hane F Moores B Amrein M | 2009 | Ultramicroscopy2009，109，8： | 1 |
| 14 | Paracrine delivery of IL - 12 against intracranial 9L gliosarcoma in rats显示文摘 | DiMeco F Rhines LD Hanes J | 2000 | J Neurosurg2000，92，3： | 1 |
| 15 | Prob- lem-Based Learning in Photonics Technology Educa- tion 显示文摘 | Massa NM Dischino M Donnelly J Hanes F | 2008 | NOVEL OPTICAL SYSTEMS DESIGN AND OPTIMIZATION XI2008，，： | 1 |
| 16 | Effect of SPC on surface potential distribution in pulmonary surfactant: Atomic force microscopy and Kelvin probe force microscopy study显示文摘 | Hane F Moores B Amrein M | 2009 | Ultramicroscopy2009，109，8： | 1 |
| 17 | Prediction of transport properties:Ⅰ viscosity of fluids and mixtures显示文摘 | Ely J F Hanely H J M | 1981 | Industrial and Engineering Chemistry Fundamentals1981，20，4： | 1 |
| 18 | Amyloid-β(1-40)restores adhesion properties of pulmonary surfactant,counteracting the effect of cholesterol显示文摘 | Hane F T Drolle E Leonenko Z | 2014 | Phys Chem Chem Phys2014，16，15： | 1 |
| 19 | Local immunotherapy with interleukin - 2 delivered from biodegradable polymer microspheres combined with interstitial chemotherapy: a novel treatment for experimental malignant glioma.显示文摘OBJECTIVE:Local delivery of carmustine(BCNU)from biodegradablepolymers prolongs survival against experi-mental brain tumors.Moreover,paracrine administration of interleukin-2(IL-2)has been shown to elicit apotent antitumor immune response and to improve survival in animal brain tumor models.We report the use of anovel polymeric microsphere delivery vehicle to release IL-2.We demonstrate both in vitro release of cytokinefrom the microspheres and histological evidence of the inflammatory response elicited by IL-2 released from themicrospheres in the rat brain.Thees microspheres are used to deliver IL-2,and biodegradable polymer wafers | Rhines LD DiMeco F Lawson HC Tyler BM Hanes J Olivi A Brem H | 2003 | 中国神经肿瘤杂志2003，1，2： | 0 |
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