| 1 | TGR5 deficiency activates antitumor immunity in non-small cell lung cancer via restraining M2 macrophage polarization显示文摘The bile acid-responsive G-protein-coupled receptor TGR5 is expressed in monocytes and macrophages,and plays a critical role in regulating inflammatory response.Our previous work has shown its role in promoting the progression of non-small cell lung cancer(NSCLC),yet the mechanism remains unclear.Here,using Tgr5-knockout mice,we show that TGR5 is required for M2 polarization of tumorassociated macrophages(TAMs)and suppresses antitumor immunity in NSCLC via involving TAMsmediated CD8+T cell suppression.Mechanistically,we demonstrate that TGR5 promotes TAMs into protumorigenic M2-like phenotypes via activating c AMP-STAT3/STAT6 signaling.Induction of c AMP production restores M2-like phenotypes in TGR5-deficient macrophages.In NSCLC tissues from human patients,the expression of TGR5 is associated with the infiltration of TAMs.The co-expression of TGR5 and high TAMs infiltration are associated with the prognosis and overall survival of NSCLC patients.Together,this study provides molecular mechanisms for the protumor function of TGR5 in NSCLC,highlighting its potential as a target for TAMs-centric immunotherapy in NSCLC. | Lifang Zhao Hongyan Zhang Xueqing Liu Shan Xue Dongfang Chen Jing Zou Handong Jiang | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 3 |
| 2 | Effect of photoionisation on initial discharge in air under nanosecond pulse voltage显示文摘Effects of photoionisation on the development and electron runaway of the initial discharge in atmospheric air under nanosecond pulse voltage were studied via twodimensional particle-in-cell/Monte Carlo collision simulations.It was found that photoionisation has little effect at the beginning of the initial discharge.However,as the discharge channel gradually develops towards the anode,photoionisation shows greater impacts on the morphology of discharge but has little influence on the velocity of discharge development.Photoionisation does not appear to have a decisive effect on the growth trend of the highest energy of runaway electrons,but it does affect the change rate of the highest energy and overall distribution of electron energy,resulting in a higher proportion of energetic electrons.The difference in the distributions of the electron energy between the two cases,with and without considering photoionisation,can be attributed to the impact of photoionisation on the discharge morphology,which in turn distorted the electric field.The spatial density distributions of the electrons produced by photoionisation further explained the differences.The authors’results explicitly demonstrate the influence of photoionisation on the development and the electron runaway of the initial discharge under nanosecond pulse voltage,which provides more comprehensive knowledge for the atmospheric air gap nanosecond pulse discharge physics. | Yutai Li Yangyang Fu Zhigang Liu Handong Li Peng Wang Haiyun Luo Xiaobing Zou Xinxin Wang | 2023 | High Voltage2023，8，2： | 2 |
| 3 | Preemptive analgesia with butorphanol in psychotic patients following modified electroconvulsive therapy A randomized controlled trial显示文摘BACKGROUND: Preemptive analgesia involves introducing an analgesic prior to the onset of pain stimulation to prevent sensitizing the nervous system to subsequent stimuli that could amplify pain. OBJECTIVE: To treat psychiatric patients with intravenous (i.v.) injection of butorphanol prior to modified electroconvulsive therapy, and to observe its effect on alleviating myalgia after treatment and adverse reactions. DESIGN: A randomized controlled observation. SETTING: Renmin Hospital of Wuhan University. PARTICIPANTS: A total of 120 psychiatric patients, who accepted modified electroconvulsive therapy, were selected from the Mental Health Center of Wuhan University from June to September in 2006. All patients corresponded to the Chinese Classification and Diagnostic Criteria of Mental Disorders, and those with diseases of heart, liver, lung and kidney, glaucoma, intracranial hypertension, hyperthyreosis, and hyperkalemia were excluded. The patients were randomly divided into a control group (n = 60) and treatment group (n = 60). In the control group, there were 42 males and 18 females, aged 17-50 years, with a mean age of (34 ± 11) years. The patients weighed 50-70 kg, with a mean body mass of (63 ± 18) kg. In the treatment group, there were 40 males and 20 females, aged 20-54 years, with a mean age of (36 ± 13) years. The patients weighed 48-72 kg, with a mean body mass of (64 ± 16) kg. Approval was obtained from the Hospital's Ethics Committee. Informed consents were obtained from the patients' relatives. A SPECTRUM5000Q multifunctional mobile electroconvulsive therapy apparatus (CORPERATION, USA) was used. METHODS: ① Treatments: In the control group, the patients were anesthetized by i.v. injection of propofol (AstraZeneca, Italy, No.CN309) containing 0.075% efedrina, and then modified electroconvulsive therapy was performed. Circulation, respiration, and firing of brain electrical activity were continuously monitored. In the treatment group, the patients were i.v. injected with 1 mg of butorphanol tartrate parenteral solution (Jiangsu Hengrui Medicine Co., Ltd., No.05100732) 5 minutes prior to anesthesia; the remaining treatments were the same as in the control group. ② Evaluations: myalgia conditions were assessed 6 hours after the patients opened their eyes. The patients were evaluated by a visual analogue scale and Ramsay sedation scale immediately, and at 3 minutes and 6 hours after they opened their eyes. MAIN OUTCOME MEASURES: ① Conditions of myalgia. ② Scores of visual analogue scale and Ramsay sedation scale. RESULTS: All 120 psychiatric patients were involved in the final analysis. ① Conditions of myalgia: 6 hours after modified electroconvulsive therapy, 22 patients in the control group and 1 patient in the treatment group complained of myalgia, which resulted in a significant difference between the two groups (P < 0.05). ② Scores of visual analogue scale and Ramsay sedation scale: the scores of visual analogue scale at 30 minutes and 6 hours after opening eyes were significantly lower in the treatment group than the control group (P < 0.05), and the scores of Ramsay sedation scale were not significantly different between the two groups (P > 0.05). CONCLUSION: Preemptive analgesia by butorphanol can effectively alleviate modified electroconvulsive therapy-induced myalgia, without adverse reactions. | Lingxi WU Handong ZOU Qingshan Zhou Zhongchun Liu Bangchang Cheng | 2008 | Neural Regeneration Research2008，3，1： | 2 |
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