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| 1 | N末端脑利钠肽(NT-proBNP)对硬皮病相关性肺动脉高压的作用显示文摘Aims: The aims of this study were to evaluate the diagnostic value and to explore the prognostic value of N-terminal brain natriuretic peptide(N-TproBNP) in patients with systemic sclerosis(SSc) both with and without pulmonary arterial hypertension(PAH). Methods and results: N-TproBNP, six minute walk distance(SMWD), haemodynamics(at right heart catheterization) or tricuspid gradient(by echocardiography), and survival were assessed in 109 patients with SSc. The study population included 68 individuals with PAH[mean pulmonary artery pressure(PAP) >25 mmHg and pulmonary capillary wedge pressure< 15 mmHg] and 41 individuals without PAH. In patients with PAH, the prognostic value of baseline and change in WHO functional class, N-TproBNP levels, and SMWD were compared using Kaplan-Meier survival curves and Cox proportional hazard analysis. The mean duration of follow-up was 10 months(range 1-18 months). One year survival in patients with normal PAP was 100%when compared with 83.5%in those with SSc-PAH(P< 0.05). The patients without PAH had a mean N-TproBNP level of 139 pg/mL(SD 151); those with SSc-PAH had a significantly higher mean NTproBNP level of 1474 pg/mL(SD 2642)(P=0.0002). Among patients with PAH for every order of magnitude increase in N-TproBNP level there was a four-fold increased risk of death(P=0.002 for baseline level and P=0.006 for follow-up level). Baseline N-TproBNP levels were correlated positively with mean PAP(r=0.62; P< 0.0001), pulmonary vascular resistance(PVR)(r=0.81; P< 0.0001), and inversely with SMWD(r=-0.46; P< 0.0001). Among patients with SSc-PAH, 13 patients(19%) were in WHO functional classes Ⅱ and had mean NTproBNP levels of 325 pg/mL(SD 388). Fifty-three patients(78%) were in WHO classes Ⅲ and IV and had significantly higher mean N-TproBNP levels of 1677 pg/mL(SD 2835)-(P=0.02). At an N-TproBNP level of 395 pg/mL, the sensitivity and specificity for predicting the presence of SSc-PAH were 56 and 95%respectively. Conclusion: Raised N-TproBNP levels are directly related to the severity of PAH. In screening programs, SSc patients with an N-TproBNP in excess of 395 pg/mL have a very high probability of having pulmonary hypertension. Baseline and serial changes in N-TproBNP levels are highly predictive of survival. A 10-fold increase in N-TproBNP level on therapy is associated with a greater than three-fold increase in mortality, and may indicate therapeutic failure. | Williams M.H. Handler C.E. Akram R. J.G. Coghlan 郭俊 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，，12： | 4 |
| 2 | Clinical decision support for drug related events: Moving towards better prevention显示文摘Clinical decision support(CDS) systems with automated alerts integrated into electronic medical records demonstrate efficacy for detecting medication errors(ME) and adverse drug events(ADEs). Critically ill patients are at increased risk for ME, ADEs and serious negative outcomes related to these events. Capitalizing on CDS to detect ME and prevent adverse drug related events has the potential to improve patient outcomes. The key to an effective medication safety surveillance system incorporating CDS is advancing the signals for alerts by using trajectory analyses to predict clinical events, instead of waiting for these events to occur. Additionally, incorporating cutting-edge biomarkers into alert knowledge in an effort to identify the need to adjust medication therapy portending harm will advance the current state of CDS. CDS can be taken a step further to identify drug related physiological events, which are less commonly included in surveillance systems. Predictive models for adverse events that combine patient factors with laboratory values and biomarkers are being established and these models can be the foundation for individualized CDS alerts to prevent impending ADEs. | Sandra L Kane-Gill Archita Achanta John A Kellum Steven M Handler | 2016 | World Journal of Critical Care Medicine2016，5，4： | 2 |
| 3 | Enhancing the stability and ecological safety of mass-reared transgenic strains for field release by redundant conditional lethality systems显示文摘农业上的基因操作重要昆虫现在为更高度有效的生物学上基于的人口控制程序允许基因 sexing 和男绝育系统的开发,最尤其是无菌的昆虫技术(坐) ,为植物和动物昆虫害虫。四圜素能压制住(Tet 离开) 有条件的致命的系统可以一起工作以便转基因的种类将是在包含四圜素的节食可行、肥沃,却女性致命、男性处于没有四圜素的条件无菌。这将为无菌的男性唯一的生产在一个统一系统允许他们的很有效的使用为坐。然而,为如此的转基因的昆虫紧张的地版本的批评考虑是频率和致命性 revertant 幸存的基因基础的一颗决心。这将提供对评估致命性系统的基因稳定性必要的知识,它的环境安全,并且为保证最佳的功效的修正提供基础。为 Tet 离开致命的幸存决心,大规模屏蔽协议的开发应该也允许测试这些修正,并且测试另外的有条件的致命的系统的能力充分压制繁殖稀罕 Tet 离开幸存者。如果主导的温度敏感(DTS ) 蛹的致命性系统在果蝇为第二等的致命性证明有效,它可以提供需要支持 sexing/sterility 紧张的版本的保护措施,并且潜在地,版本不分男女致命性作为基因男绝育的一张表格拉紧。假如 DTS Prosβ2 1 变化应该为冗余的致命性证明有效,它结构、功能的保存的高水平应该允许主人特定的 cognates 为大量昆虫种类被创造。 | Alfred M. Handler | 2016 | Insect Science2016，23，2： | 2 |
| 4 | HIMSS电子健康记录定义模型(1.0版本)显示文摘应用电子健康记录是数字化医疗的更高阶段。文章从电子健康记录的定义出发,总结了电子健康记录应满足的需求。这个定义模型可以反映一个单位实现电子健康记录系统的程度。 | Thomas Handler(著) Rick Holtmeier(著) 王虹(编译) 王冬(编译) | 2007 | 中国医院2007，11，11： | 2 |
| 5 | Use of the piggyBac transposon for germline transformation of insects 显示文摘 | Handler A M | 2002 | Insect Biochemistry and Molecular Biology2002，32，： | 1 |
| 6 | Effect of Mu-Selective Opioid Antagonists on MIP-1 β and IL-1 β-induced fever显示文摘 | Handler CM Price RW Geller EB | 1998 | Ann NY Acad Sci1998，856，： | 1 |
| 7 | Succession in family business: A review of theresearch显示文摘 | Handler W C | 1994 | Family Business Review1994，7，2： | 1 |
| 8 | Enzymatic synthesis of nicotinamide mono- nueleotide显示文摘 | Preiss J Handler P | 1957 | J Biol Chem1957，225，2： | 1 |
| 9 | Patient safety culture assessment in the nursing home 显示文摘 | P Handler SM Castle NG Studenski SA | 2006 | Qual Saf Health Care2006，15，6： | 1 |
| 10 | Use of the piggyBac tmnsposon for germ-line transformation of insects 显示文摘 | HANDLER A M | 2002 | Insect Biochemistry and Molecular Bidogy2002，32，10： | 1 |
| 11 | El Nifio, volcanism, and global climate显示文摘 | HANDLER P ANDSAGER K | 1994 | Human Ecology1994，22，1： | 1 |
| 12 | Succession in family firms:a mutual role adjustment between entrepreneur and next generation family members显示文摘 | Handler WC | 1990 | Entrepreneurship:Theory and Practice1990，15，1： | 1 |
| 13 | Antioxidant,prooxidant and cytotoxic activity of hydroxylated resveratrol analogues:structure-activity relationship显示文摘 | Murias M Jager W Handler N | 2005 | Biochem Pharmacol2005，69，6： | 1 |
| 14 | A simple method for the precise determination of ≥ 40 trace elements in geological samples by ICPMS using enriched isotope internal standardisafion显示文摘 | Eggins S M Woodhead J D Kinsley L P J Mortimer G E Sylvester P McCulloch M T Hergt J M Handler M R | 1997 | Chem Geol1997，134，4： | 1 |
| 15 | Germline transformation of Drosophila melanogaster with the piggyBac transposon veetor显示文摘 | Handler AM Harrell RA | 1999 | Insect Mol Bio11999，8，4： | 1 |
| 16 | Succession in family firms:A mutual role adjustment between entrepreneur and next-generation family members显示文摘 | Handler W C | 1990 | Entrepreneurship Theory & Practice1990，15，1： | 1 |
| 17 | Temporal relationship of hepatobiliary function and morphology in rats following alphanaphylisothiocy-anate(ANIT) administration显示文摘 | Kossor D C Meunier P C Handler J A | 1993 | Toxicol Applphamacol1993，119，： | 1 |
| 18 | The lepidopter an transposon vector, piggyBac, mediates germline transforma- tion in the Mediterranean fruitfly 显示文摘 | Handler A M McCombs S D Fraser M J | 1998 | Proe Natl Aead Sei USA1998，95，13： | 1 |
| 19 | Succession in family business: A review of the research 显示文摘 | Handler W C | 1994 | Family Business Review1994，7，2： | 1 |
| 20 | The Semantic Web显示文摘 | Berners-Lee T Handler J Lassila O | 2001 | Scientific American2001，279，5： | 1 |
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