|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Heterotopic ossification after the use of recombinant human bone morphogenetic protein-7显示文摘AIM To present the incidence of heterotopic ossification after the use of recombinant human bone morphogenetic protein-7(rhB MP-7) for the treatment of nonunions.METHODS Bone morphogenetic proteins(BMPs) promote bone formation by auto-induction. Recombinant human BMP-7 in combination with bone grafts was used in 84 patients for the treatment of long bone nonunions. All patients were evaluated radiographicaly for the development of heterotopic ossification during the standard assessment for the nonunion healing. In all patients(80.9%) with radiographic signs of heterotopic ossification, a CT scan was performed. Nonunion site palpation and ROM evaluation of the adjacent jointswere also carried out. Factors related to the patient(age, gender), the nonunion(location, size, chronicity, number of previous procedures, infection, surrounding tissues condition) and the surgical procedure(graft and fixation type, amount of rhB MP-7) were correlated with the development of heterotopic ossification and statistical analysis with Pearsons χ~2 test was performed.RESULTS Eighty point nine percent of the nonunions treated with rh BMP-7, healed with no need for further procedures. Heterotopic bone formation occurred in 15 of 84 patients(17.8%) and it was apparent in the routine radiologi-cal evaluation of the nonunion site, in a mean time of 5.5 mo after the rh BMP-7 application(range 3-12). The heterotopic ossification was located at the femur in 8 cases, at the tibia in 6, and at the humerus in οne patient. In 4 patients a palpable mass was present and only in one patient, with a para-articular knee nonunion treated with rhB MP-7, the size of heterotopic ossification affected the knee range of motion. All the patients with heterotopic ossification were male. Statistical analysis proved that patient's gender was the only important factor for the development of heterotopic ossification(P = 0.007). CONCLUSION Heterotopic ossification after the use of rh BMP-7 in nonunions was common but it did not compromise the final clinical outcome in most cases, and affected only male patients. | Marianthi Papanagiotou Zoe H Dailiana Theophilos Karachalios Sokratis Varitimidis Michael Hantes Georgios Dimakopoulos Marianna Vlychou Konstantinos N Malizos | 2017 | World Journal of Orthopedics2017，8，1： | 3 |
| 2 | Buckling of jets in electrospinning显示文摘 | HANT RENEKER D H YARIN A L | 2007 | Polymer2007，48，20： | 1 |
| 3 | Modeler-independent feature recognition in a distributed environment显示文摘 | J H Hant A A Crequicha | 1998 | Computer-aided Design1998，，5： | 1 |
| 4 | Vaginal radical trachelecto- my:an oncologically safe fertility-preserving surgery, an updated series of 72 cases and review of the literature 显示文摘 | Hante M Renaud MC Francois H | 2004 | Gynecol Oncol2004，94，3： | 1 |
| 5 | Behavior of a cracked rotating shaft during passage through a critical speed显示文摘 | Hant R H Andruet R H Soberman S | 1994 | Journal of Sound and Vibration1994，173，： | 1 |
| 6 | Who should measure quality of life: the doctor or the patient? 显示文摘 | Slevin ML Hant H Lynch D | 1988 | BrJCancer1988，57，2： | 1 |
| 7 | Die Temperature Control in Pressure Die Casting显示文摘 | Chen C W Li C R HanT H etal | 1994 | AFS Transactions1994，102，： | 1 |
| 8 | A Dual-band millimeter-wave CMOS oscillator with Left-Handed resonator 显示文摘 | Yu A H T Tam S W(Rocco) K Y Socher E Hant W Chang M C F Itoh T | 2010 | IEEE Transactions on microwave theory and techniques2010，58，5： | 1 |
| 9 | 显示文摘 | WangJ P Hant D H | 1994 | J Phys Appl Phys1994，27，： | 1 |
| 10 | Modeler-independent feature recognition in a distributed environment显示文摘 | HANT J H REQUICHA A A G | 1997 | Computer-Aided Design1997，30，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员