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| 1 | COVID-19: An overview and a clinical update显示文摘The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the world.Most patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale Market.Available evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public health.At present,the research on SARS-CoV-2 is still in the primary stages.However,dexamethasone and remdesivir are appeared to be promising medical therapies.Still,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive therapies.Currently,over 150 vaccines are under investigation.It is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the disease.The knowledge about this virus is rapidly evolving,and clinicians must update themselves regularly.The present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence. | Arunkumar Krishnan James P Hamilton Saleh A Alqahtani Tinsay A Woreta | 2021 | World Journal of Clinical Cases2021，9，1： | 5 |
| 2 | Reconstructing the Primordial Spectrum of Fluctuations of the Universe from the Observed Nonlinear Clustering of Galaxies显示文摘 | Hamilton A J S Kumer P Lu E | 1991 | ApJ1991，374，： | 3 |
| 3 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 4 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 5 | Do inflammatory processes contribute to radiation-induced erythema observed in the skin of humans? 显示文摘 | Simonen P Hamilton C Ferguson S | 1998 | Radiother Oncol J1998，46，1： | 1 |
| 6 | Risk-based evaluation of different postmortem inspection procedures for pigs in Australia显示文摘 | Hamilton D R Gallas P Lyall L | 2002 | The Veterinary Record2002，151，4： | 1 |
| 7 | An integrated anal ytical approach for determining the origin of solid bitumens in the McArthur Basin,Northern Australia显示文摘 | George S C Llorca S M Hamilton P J | 1994 | Org Geochem1994，21，： | 1 |
| 8 | Q-switched neodymium YAG laser vitreolysis in the therapy of posterior segment disease 显示文摘 | Jagger JD Hamilton AM Polkinghorne P | 1990 | Graefe''s Arch Clin Exp Ophthalmol1990，228，3： | 1 |
| 9 | Natural occurrences of ochratoxicosis in poultry显示文摘 | Hamilton P A T B Huff W E Harris J R A Y | 1982 | Poultry Science1982，61，9： | 1 |
| 10 | Who's uncited now? 显示文摘 | HAMILTON D P | 1991 | Science1991，251，4989： | 1 |
| 11 | Fresh- water diatom biogeography in the Canadian Arctic Archipela- go显示文摘 | BOUCHARD G GAJEWSKI K HAMILTON P B | 2004 | JournalofBiogeography2004，，31： | 1 |
| 12 | Colorimetric method for determination of sugars and related substances显示文摘 | Dubois K A Gilles J K Hamilton P A | 1956 | Anal Chem1956，28，3： | 1 |
| 13 | The relationship of surface pressure fea- tures to the precipitation and airflow structure of an intense midlatitude squall line 显示文摘 | Johnson R H Hamilton P J | 1988 | Mon Wea Rev1988，116，7： | 1 |
| 14 | The production and emission of nitrous oxide from headwater streams in the midwestern United States显示文摘 | Beaulieu J J Arango C P Hamilton S K | 2008 | Global Change Biology2008，14，4： | 1 |
| 15 | Down and out: estimating the relationship between mental health and unemployment 显示文摘 | HAMILTON VH MERRIGAN P DUFRESNE E | 1997 | Health Econ1997，，6： | 1 |
| 16 | Pain in chil- dren with cerebral palsy: implications for pediatric physical therapy显示文摘 | Swiggum M Hamilton ML Gleeson P | 2010 | Pediatr Phys Ther2010，22，1： | 1 |
| 17 | Trade liberalisation, structural adjustment and intra - industry trade : A note 显示文摘 | Hamilton C Kniest P | 1991 | Wehwirtschaftliches Archiv1991，127，2： | 1 |
| 18 | Use of a ramp velocity test to measure critical swimming speed in Rainbow trout (Oncorhynchus mykiss) 显示文摘 | Jain K E Hamilton J C Farrell A P | 1997 | Comparative Biochemistry Physiology1997，117，： | 1 |
| 19 | Immunotherapy with a ragweed-toll-like receptor 9 agonist vaccine for allergic rhinitis显示文摘 | Creticos P S Schroeder J T Hamilton R G | 2006 | N Engl J Med2006，355，： | 1 |
| 20 | An experimental study of the standing waves in the pulse propagated through the aorta 显示文摘 | Hamilton WF Dow P | 1939 | Amer J Physiol1939，125，： | 1 |
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